Patricio Zapata

Patricio Zapata

Director Centro de Fisiología Celular e Integrativa

Tema principal: quimiorreceptores arteriales y regulación quimiosensorial ventilatoria y cardiovascular

  • Licenciado en Medicina, Pontificia Universidad Católica de Chile
  • Médico Cirujano, Universidad de Chile
  • Adiestramiento en investigación, Laboratorio Neurofisiología, Universidad Católica Chile, 1963-1964.
  • Doctor en Medicina (MD), ECFMG, USA, 1964.
  • Adiestramiento post-doctoral en investigación, Dept Physiology, Univ Utah, USA.
  • Investigador asociado, Dept Physiology, Univ Utah, USA, 1973-1974.
  • Profesor encargado, Curso Fisiología General y Neurofisiología, Pontificia Universidad Católica Chile, 1971-2002.
  • Profesor Titular, Facultad de Ciencias Biógicas, Pontificia Universidad Católica de Chile, 1973. Profesor Titular Facultad Medicina, Pontificia Universidad Católica de Chile, 1977.
  • Prof Titular visitante, Dept Physiology, Univ Utah, USA, 1982.
  • Jefe, Programa Doctorado mención Ciencias Fisiológicas, Pontificia Universidad Católica de Chile, 1983-2003.
  • Investigador principal 8 proyectos regulares FONDECYT, 1968-2005.
  • Director de 5 tesis doctorales, 1985-2005.
  • Editor Jefe, "Biological Research", 1992-1998
  • Profesor, Facultad de Medicina, CAS-Universidad Desarrollo, Chile, 2003-2006.
  • Profesor Emérito, Facultad de Medicina, Pontificia Universidad Católica de Chile, 2004 →.
  • Profesor Titular, Facultad de Medicina, CAS-Universidad Desarrollo, Chile, 2007 →.
  • Membresía sociedades científicas: Soc Biología de Chile; International Brain Research Organization (IBRO); American Physiological Soc; New York Academy of Sciences; Soc Neuroscience, USA; International Soc Arterial Chemoreception (President 1993-1996); Royal Soc Medicine, UK; Physiological Soc, UK; Soc Chilena Ciencias Fisiológicas (socio honorario, 2008 →).
  • Publicaciones científicas: 111 en inglés, 11 en castellano y 1 en francés, período 1966-2012.

 

 

Publicaciones

  • 2012    Zapata P, Larraín C, Reyes P, Fernández R. Shifting from hypoxia to hyperoxia to assess the peripheral chemosensory drive of ventilation. Adv Exp Med Biol 758: 137-142
  • 2011    Zapata P, Larraín C, Reyes P, Fernández R. Immunosensory signaling by carotid body chemoreceptors. Respir Physiol Neurobiol 178: 370-374
  • 2011    Eyzaguirre C, Fitzgerald Rs, Lahiri S, Zapata P. Arterial chemoreceptors. Comprehensive Physiology; published online Jan 1st, DOI: 10.1002/cphy.cp020316
  • 2009    Zapata P, Larraín C, Rivera Ma, Calderón C. Cardio-vascular responses to hyperoxic withdrawal of arterial chemosensory drive. Adv Exp Med Biol 648: 305-314
  • 2009    Fitzgerald Rs, Eyzaguirre C, Zapata P. Fifty years of progress in carotid body physiology. Adv Exp Med Biol 648: 23-34
  • 2008    Fernández R, González S, Rey S, Cortés Pp, Maisey Kr, Reyes Ep, Larraín C, Zapata P. Lipopolysaccharide-induced carotid body inflammation in cats: Functional manifestations, histopathology and involvement of tumour necrosis factor-a. Exp Physiol 93: 892-907
  • 2007    ZAPATA P. Is ATP a suitable co-transmitter in carotid body arterial chemoreceptors? Respir Physiol Neurobiol 157: 106-115
  • 2007    Reyes Ep, Fernández R, Larraín C, Zapata P. Effects of combined cholinergic-purinergic block upon cat carotid body chemoreceptors in vitro. Respir Physiol Neurobiol 156: 17-22
  • 2007    Reyes Ep, Fernández R, Larraín C, Zapata P. Carotid body chemosensory activity and ventilatory chemoreflexes in cats persist after combined cholinergic–purinergic block. Respir Physiol Neurobiol 156: 23-32
  • 2006    Reyes Ep, Alcayaga J, Zapata P. Are there interactions between acetylcholine- and ATP-induced responses at the level of a visceral sensory ganglion? Brain Res 1107: 97-103
  • 2005    Zapata P, Larrain C. How the carotid body works: Different strategies and preparations to solve different problems. Biol Res 38: 315-328
  • 2003    Zapata P. From oxygen sensing to chemosensory activity: The mediator role of glomus cells. Lung Biol Health Dis 175: 353-364
  • 2003    Zapata P, Larraín C, Fernández R, Reyes Ep: Cholinergic actions on carotid chemosensory system. Adv Exp Med Biol 536: 277-283
  • 2003    Iturriaga R, Cerpa V, Zapata P, Alcayaga J: Catecholamine release from isolated sensory neurons of cat petrosal ganglia in tissue culture. Brain Res 984: 104-110
  • 2003    Gonzalez C, Rocher A, Zapata P: Arterial chemoreceptors: cellular and molecular mechanisms in the adaptive and homeostatic functions of the carotid body. Rev Neurol, Spain 36: 239-254 [In Spanish]
  • 2003    Fernández R, Arriagada Y, Garrido Am, Larraín C, Zapata P: Ventilatory chemosensory drive in cats, rats and Guinea-pigs. Adv Exp Med Biol 536: 489- 495
  • 2003    Alcayaga J, Retamal M, Cerpa V, Arroyo J, Zapata P. Dopamine inhibits ATP-induced responses in the cat petrosal ganglion in vitro. Brain Res 966: 283-287
  • 2002    Fernández R, Larraín C, Zapata P. Acute ventilatory and circulatory reactions evoked by nicotine: are they excitatory or depressant? Respir Physiol Neurobiol 133: 173-182
  • 2000    Zapata P, Larraín C, Iturriaga R, Alcayaga J, Eyzaguirre C. Interactions between acetylcholine and dopamine in chemoreception. Adv Exp Med Biol 475: 495-506
  • 2000    Varas R, Alcayaga J, Zapata P. Acetylcholine sensitivity in sensory neurons dissociated from the cat petrosal ganglion. Brain Res 882: 201-205
  • 2000    Iturriaga R, Alcayaga J, Zapata P. Lack of correlation between cholinergic-induced changes in chemosensory activity and dopamine release from the cat carotid body in vitro. Brain Res 868: 380-385
  • 2000    Alcayaga J, Varas R, Arroyo J, Iturriaga R, Zapata P. Responses of petrosal ganglion neurons in vitro to hypoxic stimuli and putative transmitters. Adv Exp Med Biol 475: 389-396
  • 2000    Alcayaga J, Cerpa V, Retamal M, Arroyo J, Iturriaga R, Zapata P. Adenosine triphosphate-induced peripheral nerve discharges generated from the cat petrosal ganglion in vitro. Neurosci Lett 282: 185-188
  • 1999    Urzua J, Sauma E, Cipriano A, Guarini M, Zapata P. A model of internal control may improve the response time of an automatic arterial pressure controller. Biol Res 32: 93-100
  • 1999    Alcayaga J, Varas R, Arroyo J, Iturriaga R, Zapata P. Responses to hypoxia of petrosal ganglia in vitro. Brain Res 845: 28-34
  • 1999    Alcayaga J, Varas R, Arroyo J, Iturriaga R, Zapata P. Dopamine modulates carotid nerve responses induced by acetylcholine on the cat petrosal ganglion in vitro. Brain Res 831: 97-103
  • 1998    Alcayaga J, Iturriaga R, Varas R, Arroyo J, Zapata P. Selective activation of carotid nerve fibres by acetylcholine applied to the cat petrosal ganglion in vitro. Brain Res 786: 47-54
  • 1997    ZAPATA P. Role of scientific research in medical students’ formation. Rev Méd Chile 125: S63-S75 [In Spanish]
  • 1997    Zapata P. Chemosensory activity in the carotid nerve: Effects of physiological variables. In: Gonzalez C (ed) The Carotid Body Chemoreceptors. Berlin: Springer-Verlag. pp 97-117
  • 1997    Zapata P. Chemosensory activity in the carotid nerve: Effects of pharmacological agents. In: Gonzalez C (ed) The Carotid Body Chemoreceptors. Berlin: Springer-Verlag. pp 119-146
  • 1997    Zapata P, Iturriaga R. Modulation of arterial chemoreceptor activity and its contribution to the hypoxic response. In: CHARRIER R, ACEITUNO P, CASTRO M, Llanos A, Raggi La (eds) El Altiplano: Ciencia y Conciencia en los Andes. Santiago, Chile: Univ Chile. pp 341-348
  • 1997    Alcayaga J, Iturriaga R, Zapata P. Time structure, temporal correlation and coherence of chemosensory impulses propagated through both carotid nerves in cats. Biol Res 30: 125-133
  • 1996    Zapata P, Iturriaga R, Larraín C. Domperidone as a tool to assess the role of dopamine within carotid body chemoreception. Adv Exp Med Biol 410: 291-297
  • 1996    Zapata P, Iturriaga R, Alcayaga J. Dopamine efflux from the carotid body during hypoxic stimulation. Adv Exp Med Biol 410: 261-266
  • 1996    Zapata P, Eyzaguirre C, Torrance Rw. Preface. In: ZAPATA P, Eyzaguirre C, Torrance RW (eds) Frontiers in Arterial Chemoreception. London & New York: Plenum. pp v-vi
  • 1996    Iturriaga R, Alcayaga J, Zapata P. Dissociation of hypoxia-induced chemosensory responses and catecholamine efflux in cat carotid body superfused in vitro. J Physiol, London 497: 551-564
  • 1996    Alcayaga J, Iturriaga R, Zapata P. Coherence of chemosensory discharges in cats’ carotid nerves. Cooperative inputs or redundant afferences? Adv Exp Med Biol 410: 349-356
  • 1995    Zapata P, Larraín C. Development of a Latin American biological journal. Chapter VII in: CETTO AM, HILLERUD K-I (eds) Scientific Publications in Latin America. México: Fondo Cultura Económica. pp 89-102 [In Spanish]
  • 1994    Zapata P, Larraín C. A report on the evolution of this journal and an analysis of its present state and perspectives. Biol Res 27: 159-169
  • 1994    Zapata P, Larraín C, Iturriaga R, Alcayaga J. The carotid bodies as thermosensors: experiments in vitro and in situ, and importance for ventilatory regulation. Adv Exp Med Biol 360: 253-255
  • 1994    Torrance Rw, Iturriaga R, Zapata P. Effects of expiratory duration on chemoreceptor oscillations. Adv Exp Med Biol 360: 241-243
  • 1994    Iturriaga R, Larraín C, Zapata P. Phrenic nerve activity during artificial ventilation at different body temperatures and its relationships with carotid chemosensory activity. Biol Res 27: 145-157
  • 1994    Iturriaga R, Larraín C, Zapata P. Effects of dopaminergic blockade upon carotid chemosensory activity and its hypoxia-induced excitation. Brain Res 663: 145-154
  • 1993    Zapata P, Larraín C, Fadic R, Ramirez B, Loyola H. Thermal effects upon the chemosensory drive of ventilation. Adv Exp Med Biol 337: 371-378
  • 1993    Alcayaga J, Sanhueza Y, Zapata P. Thermal dependence of chemosensory activity in the carotid body superfused in vitro. Brain Res 600: 103‑111
  • 1992    Zapata P. Defining biomedical research. Educ Méd, U.C. 10: 155‑158 [In Spanish]
  • 1992    Oyarzún Mj, Morgado E, Dussaubat N, Lathrop Me, Iturriaga R, Larraín C, Zapata P. Comparison of the subcellular distribution of alveolar surfactant in two mammalian species of similar body weight: cat and rabbit. Comp Biochem Physiol 102: 669‑674
  • 1991    Zapata P. Physicians of the 21st century. Educ Méd, U.C. 9: 159‑161 [In Spanish]
  • 1991    ZAPATA P. Neural factors affecting ventilatory regulation may explain certain manifestations of pneumonia. Bol Esc Med Univ Catól Chile 20: 49‑51 & 153 [In Spanish]
  • 1991    Oyarzún Mj, Iturriaga R, Donoso P, Dussaubat N, Santos M, Schiappacasse Me, Lathrop Me, Larraín C, Zapata P. Factors affecting the distribution of alveolar surfactant during resting ventilation. Am J Physiol 261 (Lung Cel Molec Physiol 5): L210‑L217
  • 1991    Loyola H, Fadic R, Cárdenas H, Larraín C, Zapata P. Effects of body temperature on chemosensory activity of the cat carotid body in situ. Neurosci Lett 132: 251‑254
  • 1991    Fadic R, Larraín C, Zapata P. Thermal effects on ventilation in cats. Participation of carotid body chemoreceptors. Respir Physiol 86: 51‑63
  • 1990    Zapata P. Transduction, signal transference and encoding in composite chemoreceptors: A comparison between gustatory and arterial chemoreceptors. Chapter 6 in: Hidalgo C, Bacigalupo J, Jaimovich E, Vergara J (eds) Transduction in Biological Systems. NY: Plenum. pp 87‑98
  • 1990    Zapata P, Larraín C, Eugenín J. Restoration of chemoreflexes after unilateral carotid deafferentation. In: Acker H, Trzebski A, O’regan RG (eds) Chemoreceptors and Chemoreceptor Reflexes. NY: Plenum. pp 339‑346
  • 1990    Zapata P, Eugenín J, Larraín C. Plasticity of ventilatory chemoreflexes. Chapter 49 in: EYZAGUIRRE C, FIDONE SJ, FITZGERALD RS, LAHIRI S, Mcdonald DM (eds) Arterial Chemoreception. NY: Springer Verlag. pp 357‑362
  • 1990    Eugenín J, Larraín C, Zapata P. Functional recovery of the ventilatory chemoreflexes after partial chronic denervation of the nucleus tractus solitarius. Brain Res 523: 263‑272
  • 1990    Alcayaga J, Iturriaga R, Zapata P. Flow detection by the carotid body. Chapter 35 in: EYZAGUIRRE C, FIDONE SJ, FITZGERALD RS, LAHIRI S, Mcdonald DM (eds) Arterial Chemoreception. NY: Springer Verlag. pp 254‑259
  • 1989    Iturriaga R, Alcayaga J, Zapata P. CONFREG: a BASIC program for calculating and plotting confidence regions based on correlation analyses. Comput Meth Programs Biomed 29: 37‑42
  • 1989    Eugenín J, Larraín C, Zapata P. Correlative contribution of carotid and aortic afferences to the ventilatory chemosensory drive in steady‑state normoxia and to the ventilatory chemoreflexes induced by transient hypoxia. Arch Biol Med Exp 22: 395‑408
  • 1988    Zapata P, Torrealba G. Reflex effects evoked by stimulation of hypoglossal afferent fibers. Brain Res 445: 19‑29
  • 1988    Iturriaga R, Alcayaga J, Zapata P. Contribution of carotid body chemoreceptors and carotid sinus baroreceptors to the ventilatory and circulatory reflexes produced by common carotid occlusion. Acta Physiol Pharmacol Latinoam 38:27‑48
  • 1988    Alcayaga J, Iturriaga R, Zapata P. Flow dependent chemosensory activity in the carotid body superfused in vitro. Brain Res 455: 31‑37
  • 1987    Zapata P. The cerebral attic of Sherlock Holmes and pregraduate medical education. Rev Méd Chile 115: 992‑994 [In Spanish]
  • 1987    Zapata P, Torrealba F. Interference by domperidone on chemosensory and ventilatory responses to dopamine. In: RIBEIRO JA, PALLOT DJ (eds) Chemoreceptors in Respiratory Control. London: Croom Helm. pp 322‑333
  • 1987    Zapata P, Iturriaga R, Alcayaga J. Carotid body chemoreceptor response to transient arterial occlusion. In: Ribeiro Ja, Pallot Dj (eds) Chemoreceptors in Respiratory Control. London: Croom Helm. pp 237‑246
  • 1986    Alcayaga J, Iturriaga R, Zapata P. Carotid body chemoreceptor excitation produced by carotid occlusion. Acta Physiol Pharmacol Latinoam 36: 199‑215

 

  • 1985    Zapata P, Eyzaguirre C. Bioelectric potentials in the carotid body. Brain Res 331: 39‑50
  • 1984    Zapata P, Torrealba F. Blockade of dopamine‑induced chemosensory inhibition by domperidone. Neurosci Lett 51: 359‑364
  • 1984    Zapata P, Serani A, Cárdenas H, Lavados M. Characterisation of dopaminoceptors in carotid body chemoreceptors. In: PALLOT DJ (ed) The Peripheral Arterial Chemoreceptors. London: Croom Helm. pp 335‑344
  • 1984    Zapata P, Eyzaguirre C. Slow electric potentials of carotid body chemoreceptors. In: Pallot Dj (ed) The Peripheral Arterial Chemoreceptors. London: Croom Helm. pp 17‑26
  • 1984    Eyzaguirre C, Zapata P. Perspectives in carotid body research. J Appl Physiol 57: 931‑957
  • 1983    Zapata P, Serani A, Lavados M. Inhibition in carotid body chemoreceptors mediated by D‑2 dopaminoceptors: antagonism by benzamides. Neurosci Lett 42: 179‑184
  • 1983    Serani A, Lavados M, Zapata P. Cardiovascular responses to hypoxia in the spontaneously breathing cat: reflexes originating from carotid and aortic bodies. Arch Biol Med Exp 16: 29‑41
  • 1983    Fidone Sj, Stensaas Lj, Zapata P. Sites of synthesis, storage, release and recognition of biogenic amines in carotid bodies. In: ACKER H, O’REGAN RG (eds) Physiology of the Peripheral Arterial Chemoreceptors. Amsterdam: Elsevier/North‑Holland. pp 21‑44
  • 1983    Cárdenas H, Zapata P. Ventilatory reflexes originated from carotid and extra‑carotid chemoreceptors in rats. Am J Physiol 244: R119‑R125
  • 1982    Zapata P. Arterial chemoreceptors: searching for transmitter and modulator substances. In: KALSNER S (ed) Trends in Autonomic Pharmacology. vol 2. Baltimore, MD: Urban & Schwarzenberg. pp 343‑361
  • 1982    Zapata P, Zuazo A. Reversal of respiratory responses to dopamine after dopamine antagonists. Respir Physiol 47: 239‑255
  • 1982    Eyzaguirre C, Zapata P. Trophic interactions between sensory nerves and their pre‑neural elements. Arch Biol Med Exp 15: 219‑228
  • 1982    Eyzaguirre C, Zapata P. The carotid body. Investigación y Ciencia 70: 94‑108 [Spanish edition of Scientific American]
  • 1981    Zapata P, Zuazo A. Respiratory depression induced by chemosensory inhibition. In: Belmonte C, Pallot D, Acker H, Fidone S (eds) Arterial Chemoreceptors. Leicester: Leicester Univ Pr. pp 491‑501
  • 1981    Zapata P, Serani A. Functional role of peripheral chemoreceptors in tonic and phasic driving of ventilation. In: Belmonte C, Pallot D, Acker H, Fidone S (eds) Arterial Chemoreceptors. Leicester: Leicester Univ Pr. pp 521‑532
  • 1981    Serani A, Zapata P. Relative contribution of carotid and aortic bodies to cyanide‑induced ventilatory responses in the cat. Arch Intl Pharmacodyn Thér 252: 284‑297
  • 1981    Serani A, Zapata P. Changes in respiratory frequency originated from peripheral chemoreceptors in the cat. Intl Res Comm Syst Med Sci 9: 620‑621
  • 1981    CÁRDENAS H, ZAPATA P. Dopamine‑induced ventilatory depression in the rat, mediated by carotid nerve afferents. Neurosci Lett 24: 29‑33
  • 1980    Zuazo A, Zapata P. Regulatory role of carotid nerve afferences upon the frequency and pattern of spontaneous gasp complexes. Neurosci Lett 16: 111‑116
  • 1980    Zapata P, Zuazo A. Respiratory effects of dopamine‑induced inhibition of chemosensory inflow. Respir Physiol 40: 79‑92
  • 1980    Zapata P, Zuazo A. Indirect quantitative estimation of ventilation through paired pneumographs. IRCS Med Sci 8: 14
  • 1980    Diaz C, Cárdenas H, Zapata P. Spontaneous gasp complexes in growing and adult rats. IRCS Med Sci 8: 487‑488
  • 1980    Cárdenas H, Zapata P. Dual effects of dopamine upon chemosensory responses to cyanide. Neurosci Lett 18: 317‑322
  • 1979    Zapata P, Alvarez J. Design of a physiology course in relation to medical education. Educ Méd Salud, Washington, DC. 13: 134‑147 [In Spanish]
  • 1978    Zuazo A, Zapata P. Regional sympathectomy induced by intra‑arterial 6‑hydroxy‑dopamine. Neurosci Lett 9: 317‑322
  • 1978    Zuazo A, Zapata P. Effects of 6‑hydroxy‑dopamine on carotid body chemosensory activity. Neurosci Lett 9: 323‑328
  • 1978    Zapata P, Larraín C. Antagonism of dopamine‑induced chemosensory inhibition by ergot alkaloids. Neurosci Lett 8: 131‑136
  • 1978    Llados F, Zapata P. Effects of dopamine analogues and antagonists on carotid body chemosensors in situ. J Physiol, London 274: 487‑499
  • 1978    Llados F, Zapata P. Effects of adrenoceptor stimulating and blocking agents on carotid body chemosensory inhibition. J Physiol, London 274: 501‑509
  • 1977    Zapata P. Modulatory role of dopamine on arterial chemoreceptors. In: COSTA E, GESSA GL (eds) Non‑Striatal Dopaminergic Neurons. NY: Raven. Adv Biochem Psychopharmacol 16: 291‑298
  • 1977    Zapata P, Stensaas Lj, Eyzaguirre C. Recovery of chemosensory function of regenerating carotid nerve fibers. In: ACKER H, FIDONE S, PALLOT D, EYZAGUIRRE C, LÜBBERS DW, TORRANCE RW (eds) Chemoreception in the Carotid Body. Berlin: Springer‑Verlag. pp 44‑50
  • 1977    Zapata P, Llados F. Blockade of carotid body chemosensory inhibition. In: ACKER H, FIDONE S, PALLOT D, EYZAGUIRRE C, LÜBBERS DW, TORRANCE RW (eds) Chemoreception in the Carotid Body. Berlin: Springer‑Verlag. pp 152‑159
  • 1977    Fidone Sj, Zapata P, Stensaas Lj. Origin of nerve terminals on glomus cells in cat carotid body: a study of axoplasmic movement of labeled material along sensory neurons of the petrosal ganglion. In: ACKER H, FIDONE S, PALLOT D, EYZAGUIRRE C, LÜBBERS DW, TORRANCE RW (eds) Chemoreception in the Carotid Body. Berlin: Springer‑Verlag. pp 9‑16
  • 1977    Fidone Sj, Zapata P, Stensaas Lj. Axonal transport of labeled material into sensory nerve endings of cat carotid body. Brain Res 124: 9‑28
  • 1976    Zapata P, Zuazo A, Llados F. Respiratory and circulatory reflexes induced by nicotine injections: role of carotid body chemoreceptors. Arch Intl Pharmacodyn Thér 219: 128‑139
  • 1976    Zapata P, Zuazo A, Llados F. Acute changes in ventilation and blood pressure induced by inhalation of tobacco smoke. Arch Intl Pharmacodyn Thér 219: 116‑127
  • 1976    Zapata P, Stensaas LJ, Eyzaguirre C. Axon regeneration following a lesion of the carotid nerve: electrophysiological and ultrastructural observations. Brain Res 113: 235‑253
  • 1976    Morgado E, Llados F, Zapata P. Dopamine‑β‑hydroxylase activity in normal and sympathectomized carotid bodies. Neurosci Lett 3: 139‑143
  • 1976    Donoso Aj, Zapata P. Effects of denervation and decentralization upon taste buds. Experientia, Basel 32: 591‑592
  • 1975    Zapata P. Effects of dopamine on carotid chemo‑ and baroreceptors in vitro. J Physiol, London 244: 235‑251
  • 1975    Fidone Sj, Stensaas LJ, Zapata P. Sensory nerve endings containing synaptic vesicles: an electron‑microscope autoradiographic study. J Neurobiol 6: 423‑427
  • 1974    Llados F, Zapata P. Effects of blockers of protein synthesis upon fibrillation due to denervation. Acta Physiol Latinoam 24: 48‑56
  • 1973    Zapata P. Neurotrophic effects upon muscles and receptors of the cat’s tongue. Acta Physiol Latinoam 23: 610‑613
  • 1972    Zapata P. Pathophysiological bases of spinal shock. Medicina, Bs Aires. 32: 395‑401 [In Spanish]
  • 1972    HESS A, ZAPATA P. Innervation of the cat carotid body: Normal and experimental studies. Fed Proc 31: 1365‑1382
  • 1972    Eyzaguirre C, Fidone S, Zapata P. Membrane potential changes recorded from the mucosa of the toad’s tongue during chemical stimulation. J Physiol, London 221: 515‑532
  • 1971    Zapata P, Torrealba G. Mechanosensory units in the hypoglossal nerve of the cat. Brain Res 32: 349‑367
  • 1970    Donoso A, Zapata P, Alvarez J. Incorporation of tritiated choline by the carotid body incubated in vitro. Arch Biol Med Exp 7: 1‑7 [In Spanish]
  • 1969    Zapata P, Hess A, Eyzaguirre C. Reinnervation of carotid body and sinus with superior laryngeal nerve fibers. J Neurophysiol 32: 215‑228
  • 1969    Zapata P, Hess A, Bliss El, Eyzaguirre C. Chemical, electron microscopic and physiological observations on the role of catecholamines in the carotid body. Brain Res 14: 473‑496
  • 1968    Eyzaguirre C, Zapata P. The release of acetylcholine from carotid body tissues. Further study on the effects of acetylcholine and cholinergic blocking agents on the chemosensory discharge. J Physiol, London 195: 589‑607
  • 1968    Eyzaguirre C, Zapata P. Pharmacology of pH effects on carotid body chemoreceptors in vitro. J Physiol, London 195: 557‑588
  • 1968    Eyzaguirre C, Zapata P. Chemical transmission of excitation at the level of carotid chemoreceptors. Actualités Neurophysiol, Paris 8: 73‑88 [In French]
  • 1968    Eyzaguirre C, Zapata P. A discussion of possible transmitter or generator substances in carotid body chemoreceptors. In: TORRANCE RW (ed) Arterial Chemoreceptors. Oxford: Blackwell. pp 213‑251
  • 1967    Zapata P, Eyzaguirre C. Bioassay of acetylcholine on the sinus venosus of the frog. Can J Physiol Pharmacol 45: 1021‑1032
  • 1966    Zapata P. Peripheral and central factors in the pathophysiology of spinal shock. Acta Physiol Latinoam 16: 266‑277
  • Monograph:
  • 1996    Zapata P, Eyzaguirre C, Torrance RW (eds) Frontiers in Arterial Chemoreception. London & New York: Plenum. xiii + 480 pp
  • Chapter in Encyclopedia:
  • 1983    Eyzaguirre C, Fitzgerald Rs, Lahiri S, Zapata P. Arterial chemoreceptors. In: American Physiological Society: Handbook of Physiology, sect 2: The Cardiovascular System, vol 3: Peripheral Circulation and Organ Blood Flow. Baltimore, MD: Williams & Wilkins. Part 2; chapter 16; pp 557‑621; refs 589.
  • 2011    Reproduced in Comprehensive Physiology, for online availability.