Paola Campodónico

Paola  Campodónico

Paola Campodónico

Directora e Investigadora Docente

Licenciada en Química, Universidad de Santiago de Chile. Químico, Universidad de Santiago de Chile. Doctor en Ciencias mención Química, Pontificia Universidad Católica de Chile.

 

CARGO ACTUAL:

Directora del Centro de Química Médica.

 

DOCENCIA:

Coordinadora y Docente del curso de Química General y Química Orgánica de la carrera de Medicina. En éste, la Dra. Campodónico se desempeña como Profesor de Cátedra, Trabajos Prácticos y de Talleres de Cátedra.

 

INVESTIGACIÓN:

La Dra. Campodónico realiza investigación en efectos del medio de polaridad variable.

 

PROYECTOS EN EJECUCIÓN:

  • Experimental & theoretical studies on nucleophilic substitution reactions in solvents of varying polarity. Investigador Responsable. Proyecto Fondecyt Regular # 1150759. Clínica Alemana-Universidad del Desarrollo
  • Iniciativa Científica Milenio RC-130006 CILIS: Centro Interdisciplinario de Líquidos Iónicos. Investigador Asociado.

 

PUBLICACIONES CON AFILIACIÓN DEL CENTRO:

  • Site activation effects promoted by intramolecular hydrogen bond interactions in snar reactions. Sebastian Gallardo-Fuentes, Ricardo A. Tapia, Renato Contreras and Paola R. Campodónico. RSC Advances, 4, 30638, 2014.
  • Mechanistic pathways in aromatic nucleophilic substitution in conventional solvents and ionic liquids. Marcela Gazitúa, Ricardo A. Tapia, Renato Contreras and Paola R. Campodónico. New Journal of Chemistry, 38, 2611, 2014.
  • Changes in the SNAr reaction mechanism brought about by preferential solvation. Jazmín Alarcón-Espósito, Ricardo A. Tapia, Renato Contreras and Paola R. Campodónico. RSC Adv., 2015, 5, 99322–99328
  • Ionic Liquids binary mixtures: how different factors contribute to determine their effect on the reactivity. Salvatore Marullo, Francesca D’Anna , Paola R. Campodonico and Renato Noto RSC Adv., 2016, 6, 90165
  • Gutmann’s Donor Numbers Correctly Assess the Effect of the Solvent on the Kinetics of SNAr Reactions in Ionic Liquids. Jazmín Alarcón-Espósito, Renato Contreras, Ricardo A. Tapia, and Paola R. Campodónico. Chem. Eur. J. 2016, 22, 13347 – 13351
  • Capítulo de libro: Título Libro: Arene Chemistry: Reaction Mechanisms and Methods for Aromatic Compounds. Título Capítulo: Computational and Experimental Methods for Predicting Reaction Mechanisms in Nucleophilic Aromatic Substitutions. Autores: Renato Contreras, Rodrigo Ormazábal-Toledo, Paola R. Campodónico. Editorial: John Wiley & Sons. Editor: Jacques Mortier

 

PUBLICACIONES PREVIAS:

  • Kinetic and theoretical study on nucleofugality in the phenolysis of 3-nitrophenyl and 4-nitrophenyl 4-cyanophenyl thionocarbonates. Enrique A. Castro, Álvaro Cañete, Paola R. Campodónico, Marjorie Cepeda, Paulina Pavez, Renato Contreras and José G. Santos. Chemical Physics Letters, 572, 130, 2013.
  • Hydrogen bond contribution to preferential solvation in snar reactions. Rodrigo Ormazábal-Toledo, José G. Santos, Paulina Ríos, Enrique A. Castro, Renato Contreras, Paola R. Campodónico. The Journal of Physical Chemistry B, 117, 5908, 2013
  • Specific nucleophile-electrophile interactions in nucleophilic aromatic substitutions. Rodrigo Ormazábal-Toledo, Renato Contreras, Ricardo A. Tapia and  Paola R. Campodónico. Organic and Biomolecular Chemistry, 11, 2302, 2013
  • Reactivity indices profile: a companion tool of the potential energy surfaces for the analysis of reaction mechanisms. Nucleophilic aromatic substitution. Rodrigo Ormazábal-Toledo, Renato Contreras and  Paola R. Campodónico. The Journal of Organic Chemistry, 78, 1091, 2013
  • Predicting the reaction mechanism of nucleophilic substitutions at carbonyl and thio-carbonyl centre. Rodrigo Ormazábal-Toledo, Enrique A. Castro, José G. Santos, Daniela Millán, Álvaro Cañete, Renato Contreras, Paola R. Campodónico. Journal of Physical Organic Chemistry, 25, 1359, 2012.
  • Are electrophilicity and electrofugality related concepts? a density functional theory study. Rodrigo Ormazábal-Toledo, Paola R. Campodónico, Renato Contreras. Organic Letters, 13, 822, 2011
  • Reactions of aryl acetates with secondary alicyclic amines in ethanol/water mixtures: effect of the solvent composition on the kinetics and mechanism. Enrique A. Castro, Daniela Millán, Raul Aguayo, Paola R. Campodónico, José G. Santos. International Journal of Chemical Kinetics, 43, 687, 2011
  • Permanent group effect on nucleofugality in aryl benzoates. Paola R. Campodónico, Rodrigo Ormazábal-Toledo, Arie Aizman and Renato Contreras. Chemical Physics Letters, 498, 221, 2010
  • Reactivity of benzohydrazide derivatives towards acetylation reaction. Experimental and theoretical studies. Paola R. Campodónico, Margarita Aliaga, José G. Santos, Enrique A. Castro and Renato Contreras. Chemical Physics Letters, 488, 86, 2010
  • Experimental and theoretical studies on the nucleofugality patters in the aminolysis and phenolysis of s- aryl o-aryl thiocarbonates. Enrique A. Castro, Margarita Aliaga, Paola R. Campodónico, Marjorie Cepeda, Renato Contreras and José G. Santos. Journal of Organic Chemistry, 74, 9173, 2009
  • Electrophilicity of quinones and its relationships with hydride affinity. Paola R. Campodónico, Arie Aizman and Renato Contreras. Chemical Physics Letters, 471, 168, 2009
  • Proton-transport catalysis in intramolecular rearrangements. a density functional theory study. Paola R. Campodónico, Juan Andrés, Arie Aizman and Renato Contreras. Chemical Physics Letters 464, 271, 2008
  • Structure-activity relationships for electrophilic sugars in interactions with nucleophilic biological target. Paola R. Campodónico and Renato Contreras. Bioorganic and Medicinal chemistry, 16, 3184, 2008
  • Reactions of aryl chlorothioformates with quinuclidines. a kinetic study. Enrique. A. Castro, Margarita Aliaga, Paola R. Campodónico, José. R. Leis, Luis García-Río, and José G. Santos. Journal of Physical Organic Chemistry, 21, 102, 2008
  • Electrofugality index of benzhydryl derivatives. Paola R. Campodónico, Claudio Pérez, Margarita Aliaga, Marcela Gazitúa and Renato Contreras. Chemical Physics Letters, 447, 375, 2007
  • Nucleofugality index in α-elimination reactions. Paola R. Campodónico, Arie Aizman, Juan Andrés and Renato Contreras. Chemical Physics Letters, 439, 177, 2007
  • Group electrophilicity as a model of nucleofugality in nucleophilic substitution reactions. Paola R. Campodónico, Arie Aizman and Renato Contreras. Chemical Physics Letters, 42, 340, 2006
  • Empirical scale of nucleophilicity for substituted pyridines. Paola R. Campodónico, Arie Aizman and Renato Contreras. Chemical Physics Letters, 42, 204, 2006
  • Kinetics and mechanistic study of the reaction of aryl chloroformiates with quinuclidines. Enrique A. Castro, Margarita Aliaga, Paola R. Campodónico, José G. Santos, José R. Leis and Luis García-Río. Journal of Physical Organic Chemistry, 19, 683, 2006
  • Experimental and theoretical study on the substitution reactions of aryl 2,4-dinitrophenyl carbonates with quinuclidines. Enrique A. Castro, Paola R. Campodónico, R. Contreras, P. Fuentealba, José G. Santos, J. Ramón Leis, Luis García-Río, José A. Sáez, and Luis R. Domingo. Tetrahedron, 62, 2555, 2006
  • Relationships between the electrophilicity index and experimental rate coefficient for the aminolysis of thiolcarbonates and dithiocarbonates. Paola R. Campodónico, Patricio Fuentealba, Enrique Castro, José G. Santos and Renato Contreras. The Journal of Organic Chemistry, 70, 1754, 2005
  • Relationship betwwen nucleophilicity/electrophilicity indicres reaction mechanisms for the nucleophilic substitution reactions of carbonyl and thiocarbonyl compounds. Paola Campodónico, José G. Santos, Juan Andrés and Renato Contreras.  Journal of Physical Organic Chemistry, 17, 273, 2004
  • Kinetics and mechanism of the aminolysis of 4-methylphenyl and 4-chlorophenyl-2,4-dinitrophenyl carbonates in aqueous ethanol. Enrique A. Castro, Paola Campodónico, Alejandra Toro and José G. Santos.The Journal of Organic Chemistry, 68, 15, 5930, 2003
  • A theoretical study on the relationship between nucleophilicity and ionization potentials in solution phase. Renato Contreras, Juan Andres, Vicente S. Safont, Paola R. Campodónico, José G. Santos. The Journal of Physical Chemistry A. 107, 29, 5588, 2003
  • Exploratory study of the effect of polar solvents upon the partitioning of solvents in non-aqueous reverse micellar solution. Juana J. Silver, Rubén D. Falcone, N.M Correa, M.A. Biasutti, Elsa Abuin, Eduardo Lissi and Paola  Campodonico. Langmuir, 19, 6, 2067, 2003
  • Kinetics and mechanism of the aminolysis of methyl 4-nitrophenyl, methyl 2,4-dinitrophenyl and 2,4-dinitrophenyl carbonates. Enrique A. Castro, Margarita Aliaga, Paola Campodónico and J.G. Santos. The Journal of Organic Chemistry, 67, 25, 8911, 2002
  • Kinetics and mechanism of the aminolysis of 4-nitrophenyl and 2,4-dinitrophenyl 4-methylphenyl carbonate in aqueous ethanol. Enrique A. Castro, Mónica Andújar, Paola Campodónico and José G. Santos. International Journal of Chemical Kinetics, 34, 309, 2002
  • Merocyanine-type dyes from barbituric acid derivatives. Marcos Caroli, Paola Campodónico, Elsa Abuin and J. Kossanyi. Spectrochimica Acta Part A., 57, 1183, 2001