{"id":2572,"date":"2020-08-28T11:56:19","date_gmt":"2020-08-28T15:56:19","guid":{"rendered":"http:\/\/medicina.udd.cl\/centro-genetica-genomica\/?page_id=2572"},"modified":"2020-08-28T11:56:54","modified_gmt":"2020-08-28T15:56:54","slug":"publicaciones-andres-klein","status":"publish","type":"page","link":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/","title":{"rendered":"Publicaciones"},"content":{"rendered":"\n<ul class=\"wp-block-list\"><li>Klein AD, Mazzulli JR.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29860491\">Is Parkinson\u2019s disease a lysosomal disorder?<\/a>&nbsp;Brain 2018, In Press. doi:&nbsp; &nbsp;10.1093\/brain\/awy147<\/li><li>Calderon JF, Klein AD.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6047216\/\">Controversies on the potential therapeutic use of rapamycin for treating a lysosomal cholesterol storage disease<\/a>. Mol Gen and Metabol Rep, 2018; 15:135-136<\/li><li>Klein AD,&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Modeling+diseases+in+multiple+mouse+strains+for+precision+medicine+studies\">Modeling diseases in multiple mouse strains for precision medicine studies<\/a>. Physiol Genomics 2017, 49(3):177-179.<\/li><li>Klein AD, Ferreira NS, Ben-Dor S, Duan J, Merrill Jr AH, Hardy J, Cox T, Futerman AH.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Identification+of+modifier+genes+in+a+mouse+model+of+Gaucher+disease\">Identification of modifier genes in a mouse model of Gaucher disease<\/a>. Cell Rep 2016; 6(10):2546-53.<\/li><li>Klein AD, Alvarez AR, Zanlungo S.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25345099\">The unique case of the Niemann-Pick type C cholesterol storage disorder<\/a>. Pediatr Endocrinol Rev. 2014;12 Suppl 1:166-75<\/li><li>Vitner EB, Salomon R, Farfel-Becker T, Meshcheriakova A, Ali M, Klein AD, Platt FM, Cox TM, Futerman AH. RIP3 as a novel therapeutic target for Gaucher disease. Nat Med. 2014; 20(2):204-8.<\/li><li>Klein AD, Futerman AH.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Lysosomal+Storage+Disorders%3A+Old+diseases%2C+present+and+future+challenges\">Lysosomal Storage Disorders: Old diseases, present and future challenges<\/a>. Pediatr Endocrinol Rev. 2013; Suppl 1:59-63.<\/li><li>Parra J*, Klein A*, Castro J, Morales MG, Mosqueira M, Valencia I, Cort\u00e9s V, Rigotti A, Zanlungo S.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Npc1+deficiency+in+C57BL%2F6J+genetic+background+enhances+Niemann-Pick+type+C+spleen+pathology\">Npc1 deficiency in C57BL\/6J genetic background enhances Niemann-Pick type C spleen pathology<\/a>. *both as first authors. Biochem Biophys Res Commun. 2011; 413(3):400-6.<\/li><li>Alvarez AR*, Klein A*, Castro J, Cancino GI, Amigo J, Mosqueira M, Vargas LM, Yevenes FL, Bronfman FC, Zanlungo S (2008).&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Imatinib+therapy+blocks+cerebellar+apoptosis+and+improves+neurological+symptoms+in+a+mouse+model+of+Niemann+Pick+type+C+disease\">Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann Pick type C disease<\/a>. Faseb Journal 22(10):3617-27. *both as first authors.<\/li><li>Klein A, Amigo L, Retamal MJ, Morales MG, Miquel JF, Rigotti A, Zanlungo S (2006).&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=NPC2+is+expressed+in+human+and+murine+liver+and+secreted+into+bile%3A+potential+implications+for+body+cholesterol+homeostasis\">NPC2 is expressed in human and murine liver and secreted into bile: potential implications for body cholesterol homeostasis<\/a>. Hepatology., 43:126-33.<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Klein AD, Mazzulli JR.&nbsp;Is Parkinson\u2019s disease a lysosomal disorder?&nbsp;Brain 2018, In Press. doi:&nbsp; &nbsp;10.1093\/brain\/awy147 Calderon JF, Klein AD.&nbsp;Controversies on the potential therapeutic use of rapamycin for treating a lysosomal cholesterol storage disease. Mol Gen and Metabol Rep, 2018; 15:135-136 Klein AD,&nbsp;Modeling diseases in multiple mouse strains for precision medicine studies. Physiol Genomics 2017, 49(3):177-179. Klein [&hellip;]<\/p>\n","protected":false},"author":42,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2572","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Publicaciones - Centro de Gen\u00e9tica y Gen\u00f3mica<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publicaciones - Centro de Gen\u00e9tica y Gen\u00f3mica\" \/>\n<meta property=\"og:description\" content=\"Klein AD, Mazzulli JR.&nbsp;Is Parkinson\u2019s disease a lysosomal disorder?&nbsp;Brain 2018, In Press. doi:&nbsp; &nbsp;10.1093\/brain\/awy147 Calderon JF, Klein AD.&nbsp;Controversies on the potential therapeutic use of rapamycin for treating a lysosomal cholesterol storage disease. Mol Gen and Metabol Rep, 2018; 15:135-136 Klein AD,&nbsp;Modeling diseases in multiple mouse strains for precision medicine studies. Physiol Genomics 2017, 49(3):177-179. Klein [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/\" \/>\n<meta property=\"og:site_name\" content=\"Centro de Gen\u00e9tica y Gen\u00f3mica\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-28T15:56:54+00:00\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/\",\"url\":\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/\",\"name\":\"Publicaciones - Centro de Gen\u00e9tica y Gen\u00f3mica\",\"isPartOf\":{\"@id\":\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/#website\"},\"datePublished\":\"2020-08-28T15:56:19+00:00\",\"dateModified\":\"2020-08-28T15:56:54+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Inicio\",\"item\":\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publicaciones\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/#website\",\"url\":\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/\",\"name\":\"Centro de Gen\u00e9tica y Gen\u00f3mica\",\"description\":\"\",\"inLanguage\":\"es\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Publicaciones - Centro de Gen\u00e9tica y Gen\u00f3mica","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/","og_locale":"es_ES","og_type":"article","og_title":"Publicaciones - Centro de Gen\u00e9tica y Gen\u00f3mica","og_description":"Klein AD, Mazzulli JR.&nbsp;Is Parkinson\u2019s disease a lysosomal disorder?&nbsp;Brain 2018, In Press. doi:&nbsp; &nbsp;10.1093\/brain\/awy147 Calderon JF, Klein AD.&nbsp;Controversies on the potential therapeutic use of rapamycin for treating a lysosomal cholesterol storage disease. Mol Gen and Metabol Rep, 2018; 15:135-136 Klein AD,&nbsp;Modeling diseases in multiple mouse strains for precision medicine studies. Physiol Genomics 2017, 49(3):177-179. Klein [&hellip;]","og_url":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/","og_site_name":"Centro de Gen\u00e9tica y Gen\u00f3mica","article_modified_time":"2020-08-28T15:56:54+00:00","twitter_misc":{"Tiempo de lectura":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/","url":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/","name":"Publicaciones - Centro de Gen\u00e9tica y Gen\u00f3mica","isPartOf":{"@id":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/#website"},"datePublished":"2020-08-28T15:56:19+00:00","dateModified":"2020-08-28T15:56:54+00:00","breadcrumb":{"@id":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/publicaciones-andres-klein\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Inicio","item":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/"},{"@type":"ListItem","position":2,"name":"Publicaciones"}]},{"@type":"WebSite","@id":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/#website","url":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/","name":"Centro de Gen\u00e9tica y Gen\u00f3mica","description":"","inLanguage":"es"}]}},"_links":{"self":[{"href":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/wp-json\/wp\/v2\/pages\/2572","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/wp-json\/wp\/v2\/users\/42"}],"replies":[{"embeddable":true,"href":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/wp-json\/wp\/v2\/comments?post=2572"}],"version-history":[{"count":1,"href":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/wp-json\/wp\/v2\/pages\/2572\/revisions"}],"predecessor-version":[{"id":2573,"href":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/wp-json\/wp\/v2\/pages\/2572\/revisions\/2573"}],"wp:attachment":[{"href":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/wp-json\/wp\/v2\/media?parent=2572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}