{"id":2580,"date":"2020-08-28T12:04:12","date_gmt":"2020-08-28T16:04:12","guid":{"rendered":"http:\/\/medicina.udd.cl\/centro-genetica-genomica\/?page_id=2580"},"modified":"2022-03-09T12:20:57","modified_gmt":"2022-03-09T15:20:57","slug":"juan-francisco-calderon","status":"publish","type":"page","link":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/juan-francisco-calderon\/","title":{"rendered":"Juan Francisco Calder\u00f3n"},"content":{"rendered":"
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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJuan Francisco Calder\u00f3n, PhD.\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t \u2013 Ingenier\u00eda en Biotecnolog\u00eda Molecular, Universidad de Chile.
\u2013 Ph.D en Gen\u00e9tica Humana y Biolog\u00eda Molecular, The Johns Hopkins University.
juancalderon@udd.cl<\/a> \t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/section>\n\n\n\n\n\t
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\n\t\t\t\n\t\t\t\n\t\n\t\t\t\t\t\t\n\t\t\tL\u00edneas de investigaci\u00f3n\t\t<\/h3>\n\t\t\t\t
\n\t\t\tConocer m\u00e1s<\/span>\n\t\t<\/div>\n\t<\/a>\n<\/div>\n\n\t\n\t\t\t\t\t\t\n\t\t\tPublicaciones\t\t<\/h3>\n\t\t\t\t
\n\t\t\tPapers seleccionados<\/span>\n\t\t<\/div>\n\t<\/a>\n<\/div>\n\n\t\n\t\t\t\t\t\t\n\t\t\tFinanciamiento\t\t<\/h3>\n\t\t\t\t
\n\t\t\tProyectos de investigaci\u00f3n<\/span>\n\t\t<\/div>\n\t<\/a>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/section>\n\n\n\n

Intereses:<\/strong><\/p>\n\n\n\n

  • Mi inter\u00e9s primario de investigaci\u00f3n es la utilizaci\u00f3n de modelos animales para entender el papel de la variaci\u00f3n gen\u00e9tica en la modulaci\u00f3n de fenotipos, principalmente del sistema cardiovascular. En el pasado, enfoqu\u00e9 mis estudios en la biolog\u00eda del desarrollo de cardiopat\u00edas cong\u00e9nitas en modelos murinos para mutaciones en genes que codifican para elementos de la v\u00eda de se\u00f1alizaci\u00f3n de TGF\u03b2 y que causan enfermedades mendelianas como S\u00edndrome Loeys-Dietz (LDS), entre otros. La identificaci\u00f3n de genes que interact\u00faen con esta v\u00eda de se\u00f1alizaci\u00f3n entrega nuevas posibilidades de manejo terap\u00e9utico que potencialmente podr\u00edan ser utilizados en pacientes con estas enfermedades. Mis intereses tambi\u00e9n incluyen la utilizaci\u00f3n de t\u00e9cnicas de manipulaci\u00f3n del genoma (genome engineering) tanto en l\u00edneas celulares como para la generaci\u00f3n de modelos animales que reflejen variaciones gen\u00e9ticas con posible efecto modificador de fenotipos de inter\u00e9s, de manera de poder entender su efecto en el contexto \u201cnativo\u201d del genoma del hu\u00e9sped.<\/li><\/ul>\n\n\n\n

    Interests:<\/strong><\/p>\n\n\n\n

    • My main research interest is to understand the role of Genetic variation in the modulation of phenotypes, mainly of the cardiovascular system, using animal models. In the past, I focused on studying the biology of congenital heart defects in murine models of mutations in genes that code for key elements of the TGF\u03b2 pathway and that cause mendelian disorders such as Loeys-Dietz Syndrome (LDS), among others. The identification of novel elements that interact with this signaling pathway provides new potential therapeutic targets to treat patients with these diseases. Another topic of interest is the utilization of genome engineering techniques both in cell culture and in the generation of mouse models that reflect elements of genetic variation involved in modification of the phenotype of interest, so that we can better understand the effect of this variation in the \u201cnative\u201d genetic context of the host.<\/li><\/ul>\n\n\n\n

      Reconocimientos<\/strong><\/p>\n\n\n\n

      • 2013. ASHG\/Charles J. Epstein Trainee Award for Excellence in Human Genetics Research.  Winner, 63rd Annual Meeting of the American Society of Human Genetics, Boston MA.<\/li>
      • 2008. Fulbright \u2013 CONICYT Predoctoral Training Scholarship.  Santiago, Chile<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"

        Intereses: Mi inter\u00e9s primario de investigaci\u00f3n es la utilizaci\u00f3n de modelos animales para entender el papel de la variaci\u00f3n gen\u00e9tica en la modulaci\u00f3n de fenotipos, principalmente del sistema cardiovascular. En el pasado, enfoqu\u00e9 mis estudios en la biolog\u00eda del desarrollo de cardiopat\u00edas cong\u00e9nitas en modelos murinos para mutaciones en genes que codifican para elementos de la […]<\/p>\n","protected":false},"author":42,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2580","page","type-page","status-publish","hentry"],"yoast_head":"\nJuan Francisco Calder\u00f3n - Centro de Gen\u00e9tica y Gen\u00f3mica<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/juan-francisco-calderon\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Juan Francisco Calder\u00f3n - 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