{"id":2619,"date":"2020-08-28T12:32:42","date_gmt":"2020-08-28T16:32:42","guid":{"rendered":"http:\/\/medicina.udd.cl\/centro-genetica-genomica\/?page_id=2619"},"modified":"2022-03-09T12:22:49","modified_gmt":"2022-03-09T15:22:49","slug":"cecilia-vial","status":"publish","type":"page","link":"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/cecilia-vial\/","title":{"rendered":"Cecilia Vial"},"content":{"rendered":"
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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCecilia Vial, PhD.\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t \u2013 Doctor en Ciencias Biol\u00f3gicas con menci\u00f3n en Biolog\u00eda Celular y Molecular, P. U. Cat\u00f3lica de Chile.
\u2013 Licenciado en Biolog\u00eda, P. U. Cat\u00f3lica de Chile.
mcvial@udd.cl<\/a> \t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/section>\n\n\n\n
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Publicaciones<\/h3>\n\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\tArt\u00edculos destacados<\/a>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t
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Financiamiento<\/h3>\n\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\tProyectos de investigaci\u00f3n<\/a>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/section>\n\n\n\n

Research Interest: <\/strong><\/p>\n\n\n\n

  • My research interest is in host response to viral infection, and how host and pathogens interact.  We have use hantavirus infection as a model for studying inter-individual differences that terminate in a different clinical course when infected. Andes orthohantavirus (ANDV) causes hantavirus cardiopulmonary syndrome (HCPS) which is a disease with no cure or vaccine and with a case fatality rate of 30%. Although the Chilean strain of ANDV is the same throughout the country, the clinical spectrum differs depending on individual response, requiring individual treatment. These clinical courses varies from an asymptomatic illness to death for cardiopulmonary shock The unique landscape of having an admixed population in Chile enables us to use genetic and genomic tools that are helping us understand this neglected disease pathophysiology. We are also using immunological approaches to understand host response to ANDV along with studying the virus. Our ultimate goal is to propose novel therapeutic targets and biomarkers of disease severity for HCPS.<\/li>
  • Mi inter\u00e9s en la investigaci\u00f3n es la respuesta del hospedero a las infecciones virales, y c\u00f3mo interact\u00faan el hu\u00e9sped y estos pat\u00f3genos. Hemos utilizado la infecci\u00f3n por hantavirus como un modelo para estudiar las diferencias entre individuos que terminan en un curso cl\u00ednico diferente cuando se infectan. El ortohantavirus Andes (ANDV) causa el s\u00edndrome cardiopulmonar del hantavirus (HCPS), que es una enfermedadsin cura ni vacuna y que tiene una letalidad de 30%. Aunque la cepa chilena de ANDV es la misma en todo el pa\u00eds, el espectro cl\u00ednico difiere seg\u00fan la respuesta individual, lo que requiere un tratamiento individual. Estos cursos cl\u00ednicos var\u00edan desde una enfermedad asintom\u00e1tica hasta la muerte por shock cardiopulmonar. El paisaje \u00fanico de tener una poblaci\u00f3n mestiza en Chile nos permite utilizar herramientas gen\u00e9ticas y gen\u00f3micas que nos ayudan a comprender la patofisiolog\u00eda de esta enfermedad. Tambi\u00e9n estamos utilizando enfoques inmunol\u00f3gicos para comprender la respuesta de los pacientes al ANDV junto con el estudiar al virus y su roedor portador. Nuestro objetivo final es proponer nuevos blancos terap\u00e9uticos y biomarcadores de gravedad de la enfermedad para HCPS.<\/li><\/ul>\n\n\n\n

    L\u00edneas de investigaci\u00f3n<\/p>\n\n\n\n

    • Hantavirus y Gen\u00f3mica Humana <\/li><\/ul>\n\n\n\n

      Afiliaciones:<\/strong><\/p>\n\n\n\n

      • Miembro de la Sociedad Americana de Gen\u00e9tica Humana (ASHG)<\/li>
      • Miembro de la Sociedad de  Gen\u00e9tica de Chile (SOCHIGEN)<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"

        Research Interest:  My research interest is in host response to viral infection, and how host and pathogens interact.  We have use hantavirus infection as a model for studying inter-individual differences that terminate in a different clinical course when infected. Andes orthohantavirus (ANDV) causes hantavirus cardiopulmonary syndrome (HCPS) which is a disease with no cure or […]<\/p>\n","protected":false},"author":42,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2619","page","type-page","status-publish","hentry"],"yoast_head":"\nCecilia Vial - Centro de Gen\u00e9tica y Gen\u00f3mica<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicina.udd.cl\/centro-genetica-genomica\/cecilia-vial\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cecilia Vial - Centro de Gen\u00e9tica y Gen\u00f3mica\" \/>\n<meta property=\"og:description\" content=\"Research Interest:  My research interest is in host response to viral infection, and how host and pathogens interact.  We have use hantavirus infection as a model for studying inter-individual differences that terminate in a different clinical course when infected. 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