{"id":2618,"date":"2018-03-22T11:09:07","date_gmt":"2018-03-22T14:09:07","guid":{"rendered":"http:\/\/medicina.udd.cl\/centro-medicina-regenerativa\/?post_type=person&p=2618"},"modified":"2020-04-27T09:53:28","modified_gmt":"2020-04-27T13:53:28","slug":"lorena-lobos","status":"publish","type":"person","link":"https:\/\/medicina.udd.cl\/centro-medicina-regenerativa\/persona\/lorena-lobos\/","title":{"rendered":"Lorena Lobos, PhD"},"featured_media":2752,"template":"","people_tax":[4034,4037,4035],"people_areas":[],"people_levels":[],"class_list":["post-2618","person","type-person","status-publish","has-post-thumbnail","hentry","people_tax-autoridad","people_tax-equipo","people_tax-profesor","people_list-centro-de-medicina-regenerativa"],"yoast_head":"\nLorena Lobos, PhD - Centro de Medicina Regenerativa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicina.udd.cl\/centro-medicina-regenerativa\/persona\/lorena-lobos\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lorena Lobos, PhD - 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Mag\u00edster en Bioqu\u00edmica, Universidad de Chile. Doctor en Bioqu\u00edmica, Universidad de Chile.<\/p>\n\t\t\t\t\t\t\t\t\t\t<p> <\/p>\n<p><strong>Cargo actual\u00a0<\/strong><\/p>\n<ul>\n<li>Investigador docente, Centro de Medicina Regenerativa, Facultad de Medicina Cl\u00ednica Alemana, Universidad del Desarrollo.<\/li>\n<li>Director Tesis de Doctorado:\n<ul>\n<li>Eduardo Dur\u00e1n, Alumno del Doctorado de Ciencias M\u00e9dicas e Innovaci\u00f3n en Medicina, Facultad de Medicina Cl\u00ednica Alemana, Universidad del Desarrollo.<\/li>\n<li>T\u00edtulo: Estudio in vitro e in vivo del rol pro-metast\u00e1sico de CAV1 en exosomas originados a partir de la l\u00ednea celular de c\u00e1ncer de mama metast\u00e1sico.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>L\u00ednea de investigaci\u00f3n<\/strong><\/p>\n<ul>\n<li>Exosomas; capacidad de preparar nichos metast\u00e1sicos en c\u00e1ncer de mama.<\/li>\n<\/ul>\n<p><strong>Publicaciones\u00a0<\/strong><b>(27 indexadas NCBI; 4 Capitulo de libro; 1 NCBI sequence; 2 No indexadas)<\/b><\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Exosomes+released+upon+mitochondrial+ASncmtRNA+knockdown+reduce+tumorigenic+properties+of+malignant++breast+cancer+cells.\">Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant\u00a0 breast cancer cells<\/a>. L Lobos-Gonz\u00e1lez*, R Bustos, A Campos, V Silva, V Silva, E Jeldes, C Salomon, M Varas-Godoy, A Caceres-Verschae, E Duran, T Vera, F Ezquer, M Ezquer, J Villegas, VA. Burzio. Scientific Reports, 10 (343) 2020 *Correspondig Author<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Targeting+antisense+mitochondrial+noncoding+RNAs+induces+bladder+cancer+cell+death+and+inhibition+of+tumor+growth+through+reduction+of+survival+and+invasion+factors.\">Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors.<\/a>\u00a0V Borgna&, L Lobos-Gonz\u00e1lez&, F Guevara, E Landerer, M Bendek, R \u00c1vila, V Silva, C Villota, M Araya, A Rivas*, C L\u00f3pez, T Socias, J Castillo, L Alarc\u00f3n, LO. Burzio, VA. Burzio and J Villegas\u00a0J Cancer 11(7):1780-1791 2020 &equal contribution<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Src-family+kinase+inhibitors+block+early+steps+of+caveolin-1-enhanced+lung+metastasis+by+melanoma+cells\">Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells<\/a>. Ortiz R, D\u00edaz J, D\u00edaz-Valdivia N, Mart\u00ednez S, Contreras P, Lobos-Gonz\u00e1lez L, Guerrero S, Leyton L, Quest AFG. Biochem Pharmacol\u00a0 30;177:113941\u00a0 2020<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=The+non-receptor+tyrosine+phosphatase+type+14+blocks+caveolin-1-enhanced+cancer+cell+metastasis\">The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis<\/a>. D\u00edaz-Valdivia NI, D\u00edaz J, Contreras P, Campos A, Rojas-Celis V, Burgos-Ravanal RA, Lobos-Gonz\u00e1lez L, Torres VA, Perez VI, Frei B, Leyton L, Quest AFG.\u00a0Oncogene. Mar 9. doi: 10.1038\/s41388-020-1242-3.\u00a0 2020<\/li>\n<li>Arce M, Pinto MP, Galleguillos M, Mu\u00f1oz C, Lange S, Ramirez C, Erices R, Gonzalez P, Velasquez E, Tempio F, Lopez MN, Salazar-Onfray F, Cautivo K, Kalergis AM, Cruz S, Lladser \u00c1, Lobos-Gonz\u00e1lez L, Valenzuela G, Olivares N, S\u00e1ez C, Koning T, S\u00e1nchez FA, Fuenzalida P, Godoy A, Contreras Orellana P, Leyton L, Lugano R, Dimberg A, Quest AFG, Owen GI. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Coagulation+Factor+Xa+Promotes+Solid+Tumor+Growth%2C+Experimental+Metastasis+and+Endothelial+Cell+Activation\">Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation<\/a>. Cancers (Basel). 2019 Aug 2;11(8). doi: 10.3390\/cancers11081103.<\/li>\n<li>Campos A, Burgos-Ravanal R, Gonz\u00e1lez MF, Huilcaman R, Lobos Gonz\u00e1lez L, Quest AFG.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Cell+Intrinsic+and+Extrinsic+Mechanisms+of+Caveolin-1-Enhanced+Metastasis\">Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis<\/a>.\u00a0Biomolecules. 2019 Jul 29;9(8). doi: 10.3390\/biom9080314.<\/li>\n<li>Fitzpatrick C, Bendek MF, Briones M, Farf\u00e1n N, Silva VA, Nardocci G, Montecino M, Boland A, Deleuze JF, Villegas J, Villota C, Silva V, Lobos-Gonzalez L, Borgna V, Barrey E, Burzio LO, Burzio VA. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Mitochondrial+ncRNA+targeting+induces+cell+cycle+arrest+and+tumor+growth+inhibition+of+MDA-MB-231+breast+cancer+cells+through+reduction+of+key+cell+cycle+progression+factors\">Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors<\/a>.\u00a0Cell Death Dis. 2019 May 29;10(6):423. doi: 10.1038\/s41419-019-1649-3.<\/li>\n<li>Arce, M., Pinto, M. P., Galleguillos, M., Mu\u00f1oz, C., Lange, S., Ramirez, C., Erices, R., Gonzalez, P., Velasquez, E., Tempio, F., L\u00f3pez, M. N., Salazar-Onfray, F., Cautivo, K., Kalergis, A. M., Cruz, S., Lladser, A., Lobos-Gonzalez, L., Valenzuela, G., Olivares, N., S\u00e1ez, C., Koning, T., S\u00e1nchez, F. A., Fuenzalida, P., Godoy, A., Contreras-Orellana, P., Leyton, L., Lugano, R., Dimberg, A., Quest, A. F. G., Owen, G. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Coagulation+Factor+Xa+Promotes+Solid+Tumor+Growth%2C+Experimental+Metastasis+and+Endothelial+Cell+Activation\">Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation<\/a>, CANCERS, Ago 2019, DOI: 10.3390\/cancers11081103<\/li>\n<li>Campos, America; Burgos-Ravanal, Renato; Fernanda Gonzalez, Maria; Huilcaman, Ricardo; Lobos Gonzalez, Lorena; Geoffery Quest, Andrew Frederick. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Cell+Intrinsic+and+Extrinsic+Mechanisms+of+Caveolin-1-Enhanced+Metastasis\">Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis<\/a>, BIOMOLECULES, Ago 2019, DOI: 10.3390\/biom9080314<\/li>\n<li>Campos A, Salomon C, Bustos R, D\u00edaz J, Mart\u00ednez S, Silva V, Reyes C, D\u00edaz-Valdivia N, Varas-Godoy M, Lobos Gonz\u00e1lez L*, Quest A.F.G**Correspondig Author Extracellular vesicles containing Caveolin-1 from metastatic breast cancer cells are enriched in adhesion proteins and enhance migration and invasion of recipient cells. Nanomedicine (Lond). 2018 Oct;13(20):2597-2609. doi: 10.2217\/nnm-2018-0094. Epub 2018 Oct 19<\/li>\n<li>S Guerrero, V Diaz-Garcia, P Contreras-Orellana, P Lara, S Palma, F Guzman, L Lobos-Gonz\u00e1lez, A C\u00e1rdenas, X Rojas-Silva, L Mu\u00f1oz, L Leyton, M J. Kogan, A F. G. Quest. Gold nanoparticles as tracking devices to shed light on the role of Caveolin-1 in early stages of melanoma metastasis. Nanomedicine (Lond). 2018 Jun;13(12):1447-1462. doi: 10.2217\/nnm-2017-0390. Epub 2018 Jul 4.<\/li>\n<li>D\u00edaz-Garc\u00eda V.M, Guerrero S, D\u00edaz N, Lobos-Gonz\u00e1lez L, Catal\u00e1n J, Kogan M. J, P\u00e9rez-Donoso J. M and Quest A.F.G. Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging.\u00a0International Journal of Nanomedicine, 16 October 2018 Volume 2018:13 Pages 6391\u20146412 doi: https:\/\/doi.org\/10.2147\/IJN.S165565<\/li>\n<\/ul>\n<p> <\/p>\n<p><strong>Cap\u00edtulo de libro<\/strong><\/p>\n<ul>\n<li>J Villegas Olavarria, VA. Burzio, V Borgna, L Lobos-Gonzalez, M Araya, F Guevara, C Villota and Luis O. Burzio.\u00a0Long Noncoding Mitochondrial RNAs (LncmtRNAs) as Targets for Cancer Therapy.\u00a0https:\/\/www.intechopen.com\/books\/mitochondrial-dna-new-insights\/long-noncoding-mitochondrial-rnas-lncmtrnas-as-targets-for-cancer-therapy\u00a0\u00a0(2018)<\/li>\n<\/ul>\n<p> <\/p>\n<p> <\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n"},"identifier":"1e1de8ab37b1b854aea8b11b99ce28f4037b7eb6","has_credential":[],"given_name":"Lorena","family_name":"Lobos, PhD","name":"Lorena Lobos, PhD","job_title":"Investigador docente","telephone":"","note":"Bioqu\u00edmico, Universidad Cat\u00f3lica de Valpara\u00edso. Mag\u00edster en Bioqu\u00edmica, Universidad de Chile. 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