{"id":3932,"date":"2013-07-27T17:51:09","date_gmt":"2013-07-27T21:51:09","guid":{"rendered":"http:\/\/medicina.udd.cl\/centro-genetica-humana\/persona\/mario-fernandez-a\/"},"modified":"2020-08-28T17:02:06","modified_gmt":"2020-08-28T17:02:06","slug":"mario-fernandez-a","status":"publish","type":"person","link":"https:\/\/medicina.udd.cl\/icim\/persona\/mario-fernandez-a\/","title":{"rendered":"Mario Fern\u00e1ndez, MD"},"featured_media":5154,"template":"","people_tax":[4053,4037,4035,15083],"people_areas":[],"people_levels":[],"class_list":["post-3932","person","type-person","status-publish","has-post-thumbnail","hentry","people_tax-centro-de-genetica-y-genomica","people_tax-equipo","people_tax-profesor","people_tax-programa-enfermedades-raras"],"yoast_head":"\nMario Fern\u00e1ndez, MD - ICIM<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicina.udd.cl\/icim\/persona\/mario-fernandez-a\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mario Fern\u00e1ndez, MD - 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U. Cat\u00f3lica de Chile. Residencia de Urolog\u00eda, U. de Chile. Doctoris Medicinae, Universidad de Heidelberg, Alemania. Cient\u00edfico visitante, Departamentos de Urolog\u00eda y Epidemiolog\u00eda, The University of Texas, MD Anderson Cancer Center (EEUU).<\/li>\n<\/ul>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\"><strong>L\u00ednea de investigaci\u00f3n:<\/strong> C\u00e1ncer de vejiga.<\/span><\/p>\n<p class=\"MsoNormal\"><b><span lang=\"ES-CL\">Intereses<\/span><\/b><span lang=\"ES-CL\">\u00a0<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\">Soy ur\u00f3logo cl\u00ednico con formaci\u00f3n y activo trabajo en investigaci\u00f3n; mis principales \u00e1reas de inter\u00e9s son la susceptibilidad gen\u00e9tica, epidemiolog\u00eda, carcinog\u00e9nesis y factores pron\u00f3sticos cl\u00ednicos y moleculares del c\u00e1ncer de vejiga.<\/span><span lang=\"ES-CL\">\u00a0<\/span><\/p>\n<p class=\"MsoNormal\"><b><span lang=\"EN-US\">Interests<\/span><\/b><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">I am a clinical urologist with training and active work in translational research; my main areas of interest are genetic susceptibility, epidemiology, carcinogenesis and clinical and molecular prognostic factors in bladder cancer.<\/span><\/p>\n<p class=\"MsoNormal\"><b><span lang=\"ES-CL\">Proyectos como Investigador principal<\/span><\/b><\/p>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\">\u201cDeterminantes gen\u00e9ticas asociadas al pron\u00f3stico cl\u00ednico de pacientes con<span>\u00a0 <\/span>c\u00e1ncer de vejiga con exposici\u00f3n a ars\u00e9nico\u201d, Cl\u00ednica Alemana.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">\u201cGenetic variants related to presence of bladder urothelial carcinoma in a high-risk, arsenic-exposed population in northern Chile (Antofagasta): a genome-wide association study\u201d, FONDECYT.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">\u201cNucleotide excision DNA repair proteic expression in bladder cancer: relation to smoking and clinicopathological characteristics\u201d, Cl\u00ednica Alemana.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">\u201cA panel of molecular biomarkers as predictors of tumor recurrence and progression in non-muscle invasive bladder cancer\u201d, Cl\u00ednica Alemana.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">\u201cArsenic- and non- arsenic related Bladder Cancer cell lines\u201d, PMI .<\/span><\/p>\n<p class=\"MsoNormal\"><b><span>Publicaciones seleccionadas<\/span><\/b><\/p>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\">– <u>Fern\u00e1ndez MI<\/u>, Valdebenito P, Delgado I et al. <\/span><span lang=\"EN-US\">Impact of Arsenic Exposure on Clinicopathological Characteristics of Bladder Cancer: A Comparative Study between Patients from an Arsenic-Exposed Region and Non-Exposed Reference Sites. <\/span><span lang=\"ES-CL\">Urol Oncol (2020) 38(2): 40.e1-40.e7<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\">– Vicun\u0303a L, Klimenkova O, Norambuena T, Mart\u00ednez FI, <u>Fern\u00e1ndez MI<\/u> et al. <\/span><span lang=\"EN-US\">Post-Admixture Selection on Chileans Targets Haplotype Involved in Pigmentation and Immune Defense Against Pathogens. Genome Biology and Evolution (2020); doi.org\/10.1093\/gbe\/evaa140<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">– L\u00f3pez JF, <u>Fern\u00e1ndez MI<\/u>, Coz LF. Arsenic exposure is associated with significant upper tract urothelial carcinoma health care needs and elevated mortality rates. <\/span><span>Urol Oncol (2020) 38(7): 638.e7 \u2013 638.e13<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\">– Vicu\u00f1a L, <u>Fern\u00e1ndez MI<\/u>, Vial C et al. <\/span><span lang=\"EN-US\">Adaptation to extreme environments in an admixed population from the Atacama Desert. Genome Biology and Evolution (2019) 11(9): 2468-2479<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">– Lobo N, Shariat SF, Guo CC, <u>Fern\u00e1ndez MI<\/u> et al. What Is the Significance of Variant Histology in Urothelial Carcinoma? <\/span><span>Eur Urol Focus (2020) 6(4):653-663<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\">– <u>Fern\u00e1ndez MI<\/u>, Brausi M, Clark PE et al. <\/span><span lang=\"EN-US\">Epidemiology, Prevention, Screening, Diagnosis and Evaluation: Update of the ICUD-SIU Joint Consultation on Bladder Cancer. World J Urol (2019) 37 (1): 3-13.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">– Huneeus A, Schilling A, <u>Fern\u00e1ndez MI<\/u>. Prevalence of Chlamydia Trachomatis, Neisseria Gonorrhoeae, and Trichomonas Vaginalis Infection in Chilean Adolescents and Young Adults. Journal of pediatric and adolescent gynecology (2018) 31 (4): 411-415<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">– <u>Fern\u00e1ndez MI<\/u>, Williams SB, Willis DL et al. Clinical risk stratification in patients with surgically resectable micropapillary bladder cancer. BJU Int (2017) 119 (5): 684<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">– Willis DL, <u>Fern\u00e1ndez MI<\/u>, Dickstein RJ et al. Clinical Outcomes in cT1 Micropapillary Bladder Cancer. J Urol (2015); 193(4): 1129-34<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">– <u>Fern\u00e1ndez MI<\/u>, Gong Y, Ye Y et al. <\/span><span lang=\"ES-CL\">\u03b3<\/span><span lang=\"EN-US\">-H2AX level in peripheral blood lymphocytes as a risk predictor for bladder cancer. Carcinogenesis (2013); 34(11):2543-7<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">– <u>Fern\u00e1ndez MI<\/u>, Parikh S, Grossman HB et al. The role of FISH and Cytology in Upper Urinary Tract Surveillance after Radical Cystectomy for Bladder Cancer. Urol Oncol (2012) 30(6); 821-4, 2012.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">– <u>Fern\u00e1ndez MI<\/u>, L\u00f3pez JF, Vivaldi B, Coz F. Long-term impact of arsenic in drinking water on bladder cancer health care and mortality rates twenty years after end of exposure. <\/span><span>J Urol (2012), 187: 856<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\">– Liu W, Cao Y, <u>Fern\u00e1ndez MI<\/u> et al. <\/span><span lang=\"EN-US\">Additive antitumoral effect of interleukin-12 gene therapy and chemotherapy in the treatment of urothelial bladder cancer in vitro and in vivo. Int Urol Nephrol (2011), 43(3); 721<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">– Bolenz C, Ikinger EM, Str\u00f6bel P, Trojan L, Steidler A, <u>Fern\u00e1ndez MI<\/u> et al. Topical Chemotherapy in human urothelial carcinoma explants: a novel translational tool for preclinical evaluation of experimental intravesical therapies. <\/span><span>Eur Urol (2009) 56 (3); 504-11<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\">– Bolenz C*, <u>Fern\u00e1ndez MI<\/u>*, Trojan L et al. <\/span><span lang=\"EN-US\">Lymphangiogenesis is induced in upper tract urothelial carcinoma and correlates with lymphatic tumour dissemination and poor prognosis. <\/span><span lang=\"ES-CL\">BJU Int (2009), 103 (8): 1040-1046 *equal contribution.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\">– <u>Fern\u00e1ndez MI<\/u>, Bolenz C, Trojan L et al. <\/span><span lang=\"EN-US\">Prognostic implications of lymphangiogenesis in muscle-invasive transitional cell carcinoma of the bladder. <\/span><span lang=\"ES-CL\">Eur Urol (2008), 53 (3): 571-80<\/span><\/p>\n<p class=\"MsoNormal\"><b><span lang=\"ES-CL\">Docencia<\/span><\/b><\/p>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\">Pregrado \u2013 Docente en Curso y Seminarios de Urolog\u00eda (4to a\u00f1o Medicina).<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"ES-CL\">Postgrado \u2013 Docente en Curso de Oncolog\u00eda Molecular, Programa de Diplomado en Oncolog\u00eda General (UDD e Instituto Nacional del C\u00e1ncer).<\/span><\/p>\n<p class=\"MsoNormal\"><b><span lang=\"EN-US\">Afiliaciones<\/span><\/b><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">International Bladder Cancer Network<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">International Bladder Cancer Group<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">Sociedad Chilena de Urolog\u00eda.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">European Association of Urology.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">American Urological Association.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">Deutsche Gesellschaft f\u00fcr Urologie.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">American Association for Cancer Research.<\/span><\/p>\n<p class=\"MsoNormal\"><span lang=\"EN-US\">Societ\u00e9 Internationale d\u2019Urologie<\/span><\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n"},"identifier":"41f8fb51d3889ea00c2ef32cb0b329be9ed0dbd4","has_credential":[],"given_name":"Mario","family_name":"Fern\u00e1ndez, MD ","name":"Mario Fern\u00e1ndez, MD","job_title":"Profesor Asociado","telephone":"","note":"","im":"","_self_schedule":null,"_links":{"self":[{"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/people\/3932","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/people"}],"about":[{"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/types\/person"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/media\/5154"}],"wp:attachment":[{"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/media?parent=3932"}],"wp:term":[{"taxonomy":"people_tax","embeddable":true,"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/people_tax?post=3932"},{"taxonomy":"people_areas","embeddable":true,"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/people_areas?post=3932"},{"taxonomy":"people_levels","embeddable":true,"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/people_levels?post=3932"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}