{"id":5473,"date":"2017-08-02T22:03:58","date_gmt":"2017-08-02T22:03:58","guid":{"rendered":"http:\/\/medicina.udd.cl\/icim\/?post_type=person&p=5473"},"modified":"2025-08-20T15:49:08","modified_gmt":"2025-08-20T19:49:08","slug":"andres-klein","status":"publish","type":"person","link":"https:\/\/medicina.udd.cl\/icim\/persona\/andres-klein\/","title":{"rendered":"Andr\u00e9s D. Klein, PhD"},"featured_media":14256,"template":"","people_tax":[4034,4053,4037,4035],"people_areas":[],"people_levels":[],"class_list":["post-5473","person","type-person","status-publish","has-post-thumbnail","hentry","people_tax-autoridad","people_tax-centro-de-genetica-y-genomica","people_tax-equipo","people_tax-profesor"],"yoast_head":"\nAndr\u00e9s D. Klein, PhD - ICIM<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicina.udd.cl\/icim\/persona\/andres-klein\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Andr\u00e9s D. 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Klein, PhD"}]},{"@type":"WebSite","@id":"https:\/\/medicina.udd.cl\/icim\/#website","url":"https:\/\/medicina.udd.cl\/icim\/","name":"ICIM","description":"Una iniciativa de Universidad del Desarrollo y Cl\u00ednica Alemana","inLanguage":"es"}]}},"label":"Andr\u00e9s D. Klein, PhD","role":false,"thumbnail_url":"https:\/\/medicina.udd.cl\/icim\/files\/2017\/08\/andres-klein-500x500.jpg","email":"andresklein@udd.cl","tel_job":"","content":{"rendered":"<div class=\"person-modal person-modal--scl\">\n\t<header class=\"person-modal__header\">\n\t\t<div class=\"person-modal__bg\"><\/div>\n\t\t<div class=\"modal-container\">\n\t\t\t\t\t\t<div class=\"person-modal__media\">\n\t\t\t\t<img width=\"500\" height=\"500\" src=\"https:\/\/medicina.udd.cl\/icim\/files\/2017\/08\/andres-klein-62x62.jpg\" class=\"person-modal__image wp-post-image lazyload\" alt=\"\" decoding=\"async\" loading=\"lazy\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" data-src=\"https:\/\/medicina.udd.cl\/icim\/files\/2017\/08\/andres-klein-500x500.jpg\" data-srcset=\"https:\/\/medicina.udd.cl\/icim\/files\/2017\/08\/andres-klein-500x500.jpg 500w, https:\/\/medicina.udd.cl\/icim\/files\/2017\/08\/andres-klein-300x300.jpg 300w, https:\/\/medicina.udd.cl\/icim\/files\/2017\/08\/andres-klein-150x150.jpg 150w, https:\/\/medicina.udd.cl\/icim\/files\/2017\/08\/andres-klein-62x62.jpg 62w, https:\/\/medicina.udd.cl\/icim\/files\/2017\/08\/andres-klein-250x250.jpg 250w, https:\/\/medicina.udd.cl\/icim\/files\/2017\/08\/andres-klein-126x126.jpg 126w, https:\/\/medicina.udd.cl\/icim\/files\/2017\/08\/andres-klein.jpg 512w\" \/>\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"person-modal__data\">\n\t\t\t\t<h1 class=\"person-modal__name\">Andr\u00e9s D. Klein, PhD<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"mailto:andresklein@udd.cl\" class=\"person-modal__email\">andresklein@udd.cl<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/header>\n\t<div class=\"modal-container\">\n\t\t\t<div class=\"person-modal__content text\">\n\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Doctor en Biolog\u00eda Celular y Molecular, Pontificia Universidad Cat\u00f3lica de Chile.<\/li>\n<li>Entrenamiento postdoctoral en la Universidad de Stanford y el Instituto Weizmann de Ciencias.<\/li>\n<\/ul>\n<p><strong>Intereses<\/strong><\/p>\n<p>Mi principal inter\u00e9s es descubrir genes modificadores de procesos biol\u00f3gicos, especialmente relacionados con enfermedades lisosomales. Para ello realizo estudios en m\u00faltiples cepas de ratones y en muestras humanas. Utilizamos estrategias de la biolog\u00eda de sistemas, donde se integran fenotipos cl\u00ednicos con datos gen\u00e9ticos, transcriptomas, biolog\u00eda celular, entre otros. Nuestro \u00a0objetivo es dise\u00f1ar terapias personalizadas para cada paciente basado en su propia biolog\u00eda.<\/p>\n<p><strong>Interests<\/strong><\/p>\n<p>My main interest is uncovering modifier genes of biological processes specially related to lysosomal-associated diseases. To this end we carry-out studies in multiple inbred mouse strains and in humans\u2019 samples. We use systems biology strategies, where we integrate clinical phenotypes with genetic data, transcriptomes, cell biology, among other high-throughput data. Our goal is to design tailored therapies for each patient based on his own biology.<\/p>\n<p><strong>Reconocimientos<\/strong><\/p>\n<ul>\n<li>2008: Beca CONICYT para estudios doctorales.<\/li>\n<li>2009-2011: Pew Latin American Fellow in the Biomedical Sciences.<\/li>\n<li>2009-2011: Beca Postdoctoral de la Ara Parseghian Medical Research Foundation.<\/li>\n<li>2011-2013: Beca Postdoctoral de la UK Gaucher Association.<\/li>\n<li>2013: Elegido como uno de los 5 chilenos menores de 35 a\u00f1os m\u00e1s innovadores del a\u00f1o por la revista Massachusetts Institute of Technology (MIT) technology reviews: http:\/\/www2.technologyreview.es\/tr35chile\/1433\/andres-klein\/.<\/li>\n<li>2013: Elegido uno de los 100 l\u00edderes jovenes del a\u00f1o por la Revista del S\u00e1bado, del diario El Mercurio.<\/li>\n<li>2017-2020: Asesor cient\u00edfico (Scientific Advisory Board) de Cures Within Reach.<\/li>\n<\/ul>\n<p><strong>Investigador Principal<\/strong><\/p>\n<ul>\n<li>2018 – 2021: Uncovering the genetic basis of phenotypic heterogeneity in Parkinson disease. PEW Research Center.<\/li>\n<li>2018-2022:\u00a0 Proyecto Fondecyt N 1180337 \u00abUncovering modifier genes of lysosomal biology by exploiting the natural genetic variation of inbred mouse strains\u00bb.<\/li>\n<li>2014-2016: Identification of novel genes that modify the severity of Gaucher disease. Rosetree of Trust UK.<\/li>\n<li>2016-2017: Unraveling the role of cellular clearance in GM2 gangiosidosis. \u00a0Grant from Cure and Action for Tay-Sachs (CATS) Foundation, UK.<\/li>\n<li>2017-2021: LysoMod: Genetic and Small Molecule Modifiers of Lysosomal Function. Marie Sklodowska-Curie Research and Innovation Staff Exchanges (RISE), Horizon 2020 program, Research Executive Agency, European Union.<\/li>\n<\/ul>\n<p><strong>Publicaciones destacadas<\/strong><\/p>\n<ul>\n<li>Klein AD, Mazzulli JR. Is Parkinson\u2019s disease a lysosomal disorder? Brain 2018, In Press. doi:\u00a0 \u00a010.1093\/brain\/awy147<\/li>\n<li>Calderon JF, Klein AD. Controversies on the potential therapeutic use of rapamycin for treating a lysosomal cholesterol storage disease. Mol Gen and Metabol Rep, 2018; 15:135-136<\/li>\n<li>Klein AD., Modeling diseases in multiple mouse strains for precision medicine studies. Physiol Genomics 2017, 49(3):177-179.<\/li>\n<li>Klein AD, Ferreira NS, Ben-Dor S, Duan J, Merrill Jr AH, Hardy J, Cox T, Futerman AH. Identification of modifier genes in a mouse model of Gaucher disease. Cell Rep 2016; 6(10):2546-53.<\/li>\n<li>Klein AD, Alvarez AR, Zanlungo S. The unique case of the Niemann-Pick type C cholesterol storage disorder. Pediatr Endocrinol Rev. 2014;12 Suppl 1:166-75<\/li>\n<li>Vitner EB, Salomon R, Farfel-Becker T, Meshcheriakova A, Ali M, Klein AD, Platt FM, Cox TM, Futerman AH. RIP3 as a novel therapeutic target for Gaucher disease. Nat Med. 2014; 20(2):204-8.<\/li>\n<li>Klein AD, Futerman AH. Lysosomal Storage Disorders: Old diseases, present and future challenges. Pediatr Endocrinol Rev. 2013; Suppl 1:59-63.<\/li>\n<li>Parra J*, Klein A*, Castro J, Morales MG, Mosqueira M, Valencia I, Cort\u00e9s V, Rigotti A, Zanlungo S. Npc1 deficiency in C57BL\/6J genetic background enhances Niemann-Pick type C spleen pathology. . *both as first authors. Biochem Biophys Res Commun. 2011; 413(3):400-6.<\/li>\n<li>Alvarez AR*, Klein A*, Castro J, Cancino GI, Amigo J, Mosqueira M, Vargas LM, Yevenes FL, Bronfman FC, Zanlungo S (2008). Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann Pick type C disease. Faseb Journal 22(10):3617-27. *both as first authors.<\/li>\n<li>Klein A, Amigo L, Retamal MJ, Morales MG, Miquel JF, Rigotti A, Zanlungo S (2006). NPC2 is expressed in human and murine liver and secreted into bile: potential implications for body cholesterol homeostasis. Hepatology., 43:126-33.<\/li>\n<\/ul>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n"},"identifier":"6c3cbe87d8bec491e96cbdda94bd085f8126587b","has_credential":[],"given_name":"Andr\u00e9s D.","family_name":"Klein, PhD","name":"Andr\u00e9s D. 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