{"id":903,"date":"2013-07-27T17:51:07","date_gmt":"2013-07-27T21:51:07","guid":{"rendered":"http:\/\/medicina.udd.cl\/centro-genetica-humana\/persona\/m-cecilia-vial-c\/"},"modified":"2020-02-24T18:48:53","modified_gmt":"2020-02-24T18:48:53","slug":"m-cecilia-vial-c","status":"publish","type":"person","link":"https:\/\/medicina.udd.cl\/icim\/persona\/m-cecilia-vial-c\/","title":{"rendered":"Cecilia Vial, PhD"},"featured_media":5157,"template":"","people_tax":[4037,4035,15097],"people_areas":[],"people_levels":[],"class_list":["post-903","person","type-person","status-publish","has-post-thumbnail","hentry","people_tax-equipo","people_tax-profesor","people_tax-programa-hantavirus"],"yoast_head":"\nCecilia Vial, PhD - ICIM<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicina.udd.cl\/icim\/persona\/m-cecilia-vial-c\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cecilia Vial, PhD - 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U. Cat\u00f3lica de Chile. Licenciado en Biolog\u00eda, P. U. Cat\u00f3lica de Chile.<\/li>\n<li>L\u00edneas de investigaci\u00f3n: Hantavirus y Gen\u00f3mica Humana.<\/li>\n<\/ul>\n<p><strong>Research Interest:\u00a0<\/strong><\/p>\n<ul>\n<li>My research interest is in host response to viral infection, and how host and pathogens interact.\u00a0 We have use hantavirus infection as a model for studying inter-individual differences that terminate in a different clinical course when infected. Andes orthohantavirus (ANDV) causes hantavirus cardiopulmonary syndrome (HCPS) which is a disease with no cure or vaccine and with a case fatality rate of 30%. Although the Chilean strain of ANDV is the same throughout the country, the clinical spectrum differs depending on individual response, requiring individual treatment. These clinical courses varies from an asymptomatic illness to death for cardiopulmonary shock The unique landscape of having an admixed population in Chile enables us to use genetic and genomic tools that are helping us understand this neglected disease pathophysiology. We are also using immunological approaches to understand host response to ANDV along with studying the virus. Our ultimate goal is to propose novel therapeutic targets and biomarkers of disease severity for HCPS.<\/li>\n<\/ul>\n<p> <\/p>\n<ul>\n<li>Mi inter\u00e9s en la investigaci\u00f3n es la respuesta del hospedero a las infecciones virales, y c\u00f3mo interact\u00faan el hu\u00e9sped y estos pat\u00f3genos. Hemos utilizado la infecci\u00f3n por hantavirus como un modelo para estudiar las diferencias entre individuos que terminan en un curso cl\u00ednico diferente cuando se infectan. El ortohantavirus Andes (ANDV) causa el s\u00edndrome cardiopulmonar del hantavirus (HCPS), que es una enfermedadsin cura ni vacuna y que tiene una letalidad de 30%. Aunque la cepa chilena de ANDV es la misma en todo el pa\u00eds, el espectro cl\u00ednico difiere seg\u00fan la respuesta individual, lo que requiere un tratamiento individual. Estos cursos cl\u00ednicos var\u00edan desde una enfermedad asintom\u00e1tica hasta la muerte por shock cardiopulmonar. El paisaje \u00fanico de tener una poblaci\u00f3n mestiza en Chile nos permite utilizar herramientas gen\u00e9ticas y gen\u00f3micas que nos ayudan a comprender la patofisiolog\u00eda de esta enfermedad. Tambi\u00e9n estamos utilizando enfoques inmunol\u00f3gicos para comprender la respuesta de los pacientes al ANDV junto con el estudiar al virus y su roedor portador. Nuestro objetivo final es proponer nuevos blancos terap\u00e9uticos y biomarcadores de gravedad de la enfermedad para HCPS.<\/li>\n<\/ul>\n<p><strong>Selected publications<\/strong><\/p>\n<ul>\n<li>Clement, J., Ahlm, C., Av\u0161i\u010d-\u017dupanc, T., Botten, J., Chandran, K., Jonsson,C.B., Kariwa, H., Klingstr\u00f6m, J., Klempa, B., Kr\u00fcger, D.H., Leirs, H., Li, D., Liang, M., Markoti\u0107, A.,Papa, A., Schmaljohn, C.S., Tischler, N.D., Ulrich, R.G., Vaheri, A., Vial, C., Yanagihara, R., Maes,P., Meeting report: Eleventh international conference on hantaviruses, Antiviral Research (2020), doi:\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.antiviral.2020.104733\">https:\/\/doi.org\/10.1016\/j.antiviral.2020.104733<\/a><\/li>\n<li>Hemodynamic and Pulmonary Permeability Characterization of Hantavirus Cardiopulmonary Syndrome by Transpulmonary Thermodilution, by Ren\u00e9 L\u00f3pez , Rodrigo P\u00e9rez-Araos , \u00c1lvaro Salazar, Ana L. Ulloa, Cecilia Vial ,Pablo A. Vial and Jer\u00f3nimo Graf, Viruses 2019, 11(10), 900;\u00a0<a href=\"https:\/\/doi.org\/10.3390\/v11100900\">https:\/\/doi.org\/10.3390\/v11100900<\/a><\/li>\n<li>A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile, Fernando Torres-P\u00e9rez, R. Eduardo Palma ,Dusan Boric-Bargetto ,Cecilia Vial, Marcela Ferr\u00e9s ,Pablo A. Vial ,Constanza Mart\u00ednez-Valdebenito ,Carlos Pavletic, Alonso Parra, Pablo A. Marquet and Gregory J. Mertz, Viruses 2019, 11(9), 848;<a href=\"https:\/\/doi.org\/10.3390\/v11090848\">\u00a0https:\/\/doi.org\/10.3390\/v11090848<\/a><\/li>\n<li>Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome, Ren\u00e9 L\u00f3pez, Cecilia Vial , Jer\u00f3nimo Graf, Mario Calvo, Marcela Ferr\u00e9s , Gregory Mertz , Anal\u00eda Cuiza , Begonia Ag\u00fcero, Dante Aguilera, Diego Araya, Ignacia Pailamilla ,Flavia Paratori,V\u00edctor Torres-Torres,Pablo A Vial and Hantavirus Study Group in Chile, Viruses 2019, 11(8), 693;\u00a0<a href=\"https:\/\/doi.org\/10.3390\/v11080693\">https:\/\/doi.org\/10.3390\/v11080693<\/a><\/li>\n<li>Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection, Grazielle Esteves Ribeiro ,Luis Edgardo Leon ,Ruth Perez, Analia Cuiza ,Pablo Agustin Vial, Marcela Ferres ,Gregory J. Mertz\u00a0 and Cecilia Vial *, Viruses 2019, 11(8), 680;\u00a0<a href=\"https:\/\/doi.org\/10.3390\/v11080680\">https:\/\/doi.org\/10.3390\/v11080680<\/a><\/li>\n<li>Factores de riesgo sociodemogr\u00e1ficos del s\u00edndrome cardiopulmonar por hantavirus, *Cecilia Vial C., Francisca Valdivieso R., Anal\u00eda Cuiza V., Iris Delgado B., Grazielle Ribeiro E.,Elena Llop R., Marcela Ferr\u00e9s G. Gabriela M. Repetto L., Ra\u00fal Riquelme,\u00a0 Maria Luisa Rioseco , Mario Calvo, Gregory Mertz, Pablo A. Vial C., Revista Chilena de Infectologia, 36 (4):428., 2019,\u00a0<a href=\"http:\/\/dx.doi.org\/10.4067\/S0716-10182019000400428\">http:\/\/dx.doi.org\/10.4067\/S0716-10182019000400428<\/a><\/li>\n<li>A Single-Nucleotide Polymorphism of \u03b1V\u03b23 Integrin Is Associated with the Andes Virus Infection Susceptibility, Constanza Mart\u00ednez-Valdebenito, Jenniffer Angulo, Nicole Le Corre, Claudia Marco, Cecilia Vial, Juan Francisco Miquel, Jaime Cerda, Gregory Mertz, Pablo Vial, Marcelo Lopez-Lastra, Marcela Ferr\u00e9s, Viruses 2019 11 (2):169,\u00a0<a href=\"https:\/\/doi.org\/10.3390\/v11020169\">https:\/\/doi.org\/10.3390\/v11020169<\/a><\/li>\n<li>Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert, Lucas Vicuna,\u00a0 Mario I. Fernandez, Cecilia Vial, Patricio Valdebenito, Eduardo Chaparro, Karena Espinoza, Annemarie Ziegler, Alberto Bustamante and Susana Eyheramendy, Genome Biol. Evol. 2019 11(9):2468\u20132479.\u00a0<a href=\"https:\/\/doi.org\/10.1093\/gbe\/evz172\">https:\/\/doi.org\/10.1093\/gbe\/evz172<\/a><\/li>\n<li>Cecilia Vial*, Constanza Martinez-Valdebenito, Susana Rios, Jessica Martinez, Pablo A. Vial, Marcela Ferres, Juan C.Rivera, Ruth Perez, Francisca Valdivieso, Molecular method for the detection of Andes hantavirus infection: validation for clinical diagnostics, DMID, 2016, 84 (1): 36\u201339.<\/li>\n<li>Susana Eyheramendy, Felipe I Martinez, Federico Manevy, Cecilia Vial*, Gabriela M Repetto, Genetic structure characterization of Chileans reflects historical immigration patterns, Nat Comm, 2015, 6:6472: 1-10,\u00a0<a href=\"https:\/\/doi.org\/10.1038\/ncomms7472\">https:\/\/doi.org\/10.1038\/ncomms7472<\/a><\/li>\n<li>Lay-Son Guillermo, Espinoza Karena, Vial Cecilia, Rivera Juan Carlos, Guzm\u00e1n Maria Luisa, Repetto Gabriela, Chromosomal microarrays testing in children with developmental disabilities and congenital anomalies: clinical experience, 2015, Jornal de Pediatria.91 (2): 189-195.\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.jped.2014.07.003\">https:\/\/doi.org\/10.1016\/j.jped.2014.07.003<\/a><\/li>\n<li>A nonrandomized multicenter trial of human immune plasma for treatment of hantavirus cardiopulmonary syndrome by ANDV, Vial Pablo, Valdivieso Francisca, Calvo Mario, Rioseco Maria Luisa, Riquelme Ra\u00fal, Araneda Andres, Tomicic Vinko, Graf Jer\u00f3nimo, Paredes Laura, Florenzano Matias, Bidart Teresa, Cuiza Analia, Marco Claudia, Hjelle Brian, Ye Chunyan, Hanfelt-Goade Diane, Vial Cecilia, Rivera Juan Carlos, Delgado Iris, Mertz Gregory J. Hantavirus Study Group in Chile, Antiviral Therapy, 2014,\u00a0<a href=\"https:\/\/doi.org\/10.3851\/IMP2875\">https:\/\/doi.org\/10.3851\/IMP2875<\/a><\/li>\n<li>Martinez-Valdebenito Constanza, Calvo Mario, Vial Cecilia, Mansilla Rita, Marco Claudia, Palma Eduardo, Vial Pablo, Valdivieso Francisca, Mertz Greg, Ferres Marcela, 2014, Person-to-person household and nosocomial transmission of Andes hantavirus, Southern Chile, 2011, Emerging Infectious Disease, 20 (10): 1629-1636<a href=\"https:\/\/doi.org\/10.3201\/eid2010.140353\">\u00a0https:\/\/doi.org\/10.3201\/eid2010.140353<\/a><\/li>\n<li>Pablo A. Vial, Francisca Valdivieso, Marcela Ferres, Raul Riquelme, M. Luisa Rioseco, Mario Calvo, Constanza Castillo, Ricardo D\u00edaz, Luis Scholz, Analia Cuiza, Edith Belmar, Carla Hernandez, Jessica Martinez, Sang-Joon Lee, and Gregory J. Mertz; for the Hantavirus Study Group in Chile* *Cecilia Vial, 2013, High-Dose Intravenous Methylprednisolone for Hantavirus Cardiopulmonary Syndrome in Chile: A Double-Blind, Randomized Controlled Clinical Trial, Clin Infect Disease, 57:943.\u00a0<a href=\"https:\/\/doi.org\/10.1093\/cid\/cit394\">https:\/\/doi.org\/10.1093\/cid\/cit394<\/a><\/li>\n<li>Vial C, Gutierrez J, Santander C, Cabrera D, Brandan E., 2011, Decorin interacts with CTGF\/CCN2 through LRR12 inhibiting its biological activity, J Biol Chem;286(27):24242-52<\/li>\n<li>Cabello-Verrugio, C., Cordova, G., Zu\u00f1iga, L., Vial, C., Brandan, E. \u201cConnective Tissue Growth Factor induction by lysophosphatidic acid requires transactivation of Transforming Growth Factor type beta receptors and the JNK pathway\u201d. (2011) Cell. Signaling 23(2):449-457\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.cellsig.2010.10.019\">https:\/\/doi.org\/10.1016\/j.cellsig.2010.10.019<\/a><\/li>\n<li>Nguyen, T.Q., Roestenberg, P., van Nieuwenhoven, F.A., Bovenschen, N., Li, Z., Xu, L., Oliver, N., Aten, J., Joles, J.A., Vial, C., Brandan, E., Lyons, K.M., Goldschmeding, R., 2008, CTGF inhibits BMP-7 Signalling Activity in Diabetic Nephropathy, J Am Soc Nephrol,. 19 (11):2098-107\u00a0<a href=\"https:\/\/doi.org\/10.1681\/ASN.2007111261\">https:\/\/doi.org\/10.1681\/ASN.2007111261<\/a><\/li>\n<li>Brandan,E.,Cabello-Verrugio,C.,Vial,C., 2008, Novel Regulatory Mechanisms for Proteoglycans Decorin and Biglycan During Muscle and Muscular Dystrophy, Matrix Biol, 27(8): 700-708\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.matbio.2008.07.004\">https:\/\/doi.org\/10.1016\/j.matbio.2008.07.004<\/a><\/li>\n<li>Vial,C.,Zu\u00f1iga,L.M.,Cabello-Verrugio,C.,Ca\u00f1\u00f3n,P.,Fadic,R.,Brandan,E., 2007, Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF\/CCN2), which induces their dedifferentiation, J Cell Physiol, 215:410-421\u00a0<a href=\"https:\/\/doi.org\/10.1002\/jcp.21324\">https:\/\/doi.org\/10.1002\/jcp.21324<\/a><\/li>\n<\/ul>\n<p><strong>Proyectos de investigaci\u00f3n<\/strong><\/p>\n<ul>\n<li>Understading host response to ANDV infection, immunological and transcriptomics approach. 2016 – 2019. Fondecyt Regular 2016<\/li>\n<li>Collaborative Network On Immunopathogenesis Of Hantavirus Infection. 2018. REDES.<\/li>\n<li>Unraveling the differences between mild and severe hantavirus infected patients: delineating mechanisms to propose novel therapeutic approaches. 2020. Fondecyt Regular.<\/li>\n<\/ul>\n<p><strong>Afiliaciones:<\/strong><\/p>\n<ul>\n<li>Miembro de la Sociedad Americana de Gen\u00e9tica Humana (ASHG)<\/li>\n<li>Miembro de la Sociedad de \u00a0Gen\u00e9tica de Chile (SOCHIGEN)<\/li>\n<\/ul>\n<p> <\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n"},"identifier":"b1c0b2f856355a32253764a4f2652e1eb9decca9","has_credential":[],"given_name":"Cecilia","family_name":"Vial, PhD","name":"Cecilia Vial, PhD","job_title":"","telephone":"","note":"","im":"","_self_schedule":null,"_links":{"self":[{"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/people\/903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/people"}],"about":[{"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/types\/person"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/media\/5157"}],"wp:attachment":[{"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/media?parent=903"}],"wp:term":[{"taxonomy":"people_tax","embeddable":true,"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/people_tax?post=903"},{"taxonomy":"people_areas","embeddable":true,"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/people_areas?post=903"},{"taxonomy":"people_levels","embeddable":true,"href":"https:\/\/medicina.udd.cl\/icim\/wp-json\/wp\/v2\/people_levels?post=903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}