{"id":956,"date":"2013-07-27T17:50:07","date_gmt":"2013-07-27T21:50:07","guid":{"rendered":"http:\/\/medicina.udd.cl\/instituto-ciencias\/persona\/paulette-conget-phd\/"},"modified":"2026-01-14T18:24:37","modified_gmt":"2026-01-14T21:24:37","slug":"paulette-conget-phd","status":"publish","type":"person","link":"https:\/\/medicina.udd.cl\/icim\/persona\/paulette-conget-phd\/","title":{"rendered":"Paulette Conget, PhD"},"featured_media":4031,"template":"","people_tax":[4034,4037,4035],"people_areas":[],"people_levels":[],"class_list":["post-956","person","type-person","status-publish","has-post-thumbnail","hentry","people_tax-autoridad","people_tax-equipo","people_tax-profesor"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Paulette Conget - Centro de Medicina Regenerativa<\/title>\n<meta name=\"description\" content=\"Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicina.udd.cl\/icim\/persona\/paulette-conget-phd\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Paulette Conget - 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U. Cat\u00f3lica de Chile. Doctor en Ciencias, menci\u00f3n Biolog\u00eda Molecular y Celular, U. de Chile. Licenciado en Educaci\u00f3n, U. del Desarrollo. <\/p>\n\t\t\t\t\t\t\t\t\t\t<p>Bioqu\u00edmico, P. U. Cat\u00f3lica de Chile. Profesor Ense\u00f1anza Media, menci\u00f3n Biolog\u00eda. Universidad del Desarrollo.\u00a0Doctor en Ciencias, menci\u00f3n Biolog\u00eda Molecular y Celular, U. de Chile.<\/p>\n<p><b>Cargos\u00a0<\/b><\/p>\n<ul>\n<li>Profesor. Facultad de Educaci\u00f3n. Universidad del Desarrollo (2016 a la fecha)<\/li>\n<li>Profesor. Colegio La Girouette (2014 a la fecha)<\/li>\n<li>Profesor Titular. Facultad de Medicina Cl\u00ednica Alemana-Universidad del Desarrollo (2009 a la\u00a0fecha)<\/li>\n<li>Investigador y Docente. Facultad de Medicina Cl\u00ednica Alemana-Universidad del Desarrollo (2002\u00a0a la fecha)<\/li>\n<\/ul>\n<p><b><\/b><strong>Participaci\u00f3n en proyectos de investigaci\u00f3n<\/strong><\/p>\n<p><em>Investigador principal<\/em><\/p>\n<ul>\n<li>Profundigraf\u00eda: organizadores gr\u00e1ficos para suscitar aprendizaje profundo (2015) Universidad del Desarrollo (Facultad de Educaci\u00f3n)<\/li>\n<li>Do allogeneic multipotent mesenchymal stromal cells modify the progression of precancerous\u00a0lesions? (2013-2018)\u00a0FONDECYT Regular<\/li>\n<li>Cerveza y Salud. (2008-2009), (2009-2011) y (2012-2013)\u00a0Asociaci\u00f3n Chilena de Productores de Cerveza<\/li>\n<li>Medicina Regenerativa para diabetes y sus complicaciones. (2006-2009)\u00a0Programa Bicentenario de Ciencias y Tecnolog\u00eda Inserci\u00f3n de post-doctorados en la academia<\/li>\n<li>Prote\u00f3mica diferencial: estrategia para identificar los factores que inducen la movilizaci\u00f3n de\u00a0c\u00e9lulas troncales mesenquim\u00e1ticas desde la m\u00e9dula \u00f3sea al coraz\u00f3n infartado. (2005-2006)\u00a0Universidad del Desarrollo (Concurso interno, VRA)<\/li>\n<li>Bloqueo selectivo de la expresi\u00f3n g\u00e9nica del alelo mutado de queratina 5 como alternativa\u00a0terap\u00e9utica para Epidermolisis Bulosa Simple. (2004-2005)\u00a0Universidad del Desarrollo (Concurso interno, VRA)<\/li>\n<li>La inducci\u00f3n g\u00e9nica del catabolismo de triptofano, al inhibir la activaci\u00f3n local de linfocitos T,\u00a0promueve tolerancia y prolonga la expresi\u00f3n de transgenes movilizados por vectores\u00a0adenovirales. (2000-2001)\u00a0FONDECYT Regular<\/li>\n<li>Integrinas alfa v en c\u00e9lulas blanco determinan la eficiencia de la transferencia g\u00e9nica mediada\u00a0por vectores adenovirales. (1997-1999)\u00a0FONDECYT Doctorado<\/li>\n<\/ul>\n<p><em>Co-investigador principal<\/em><\/p>\n<ul>\n<li>Estudio cl\u00ednico fase II: Implante de c\u00e9lulas madre mesenquim\u00e1ticas para tratar pacientes con\u00a0Incontinencia de Orina post-Estr\u00e9s. (2013-2015)\u00a0Mutual Chilena de Seguridad<\/li>\n<li>Estudio cl\u00ednico fase II: Administraci\u00f3n intravenosa de c\u00e9lulas madre mesenquim\u00e1ticas para\u00a0tratar pacientes con Diabetes Mellitus Tipo 1. (2012-2016)\u00a0Corporaci\u00f3n Chileno Alemana de Beneficencia<\/li>\n<li>Estudio cl\u00ednico fase II: Administraci\u00f3n intravenosa de c\u00e9lulas madre mesenquim\u00e1ticas\u00a0alog\u00e9nicas para tratar pacientes con Epidermolisis Bulosa Distr\u00f3fica Generalizada. (2012-2015)\u00a0DebRA<\/li>\n<li>Implante de c\u00e9lulas madre mesenquim\u00e1ticas contribuyen a la recuperaci\u00f3n estructural de la\u00a0fascia de la pared vaginal de mujeres con prolapso genital: evidencia ex vivo.\u00a0(2011-2013)\u00a0Cl\u00ednica Alemana Santiago<\/li>\n<li>Estudio cl\u00ednico fase II: Tratamiento intrauterino de pacientes con Osteogenesis Imperfecta con\u00a0c\u00e9lulas madre mesenquim\u00e1ticas. (2008-2015)\u00a0Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo<\/li>\n<\/ul>\n<p><strong>\u00daltimas publicaciones<\/strong><\/p>\n<ul>\n<li>Plaza A, Bruna F, Arango-Rodr\u00edguez M, Espinoza I and Conget P. Mesenchymal stem cell administration impairs oral dysplasia progression. Cytotherapy (enviado)<\/li>\n<li>Bruna F, Plaza A, Arango-Rodr\u00edguez M, Espinoza I and Conget P. Systemically administered allogeneic mesenchymal stem cells do not aggravate the progression of precancerous lesions: a new biosafety insight. Stem Cell Res &amp; Ther 9: 137. doi.org\/10.1186\/s13287-018-0878-1<\/li>\n<li>Rojo D and Conget P. (2018) Acellular derivatives of mesenchymal stem cells prevent peritoneal adhesions in an experimental model. J Surg Res 223: 198-206. doi.org\/10.1016\/j.jss.2017.11.018<\/li>\n<li>Sep\u00falveda P, Carrasco E, Ramos M, Tapia L, Ramos M, Cruz F, Conget P, Olivares B and Cortinez LI. (2018) Evidence of hysteresis in propofol pharmacodynamics demonstrated by the use of up and down steady state steps in volunteers. Anaesthesia 73: 40-48. doi:10.1111\/anae.14009<\/li>\n<li>Lazcano X, Villal\u00f3n, F, Vera S y Conget P. (2017) La creencia epistemol\u00f3gica constructivista sobre el conocimiento cient\u00edfico var\u00eda en funci\u00f3n del a\u00f1o de formaci\u00f3n en los estudiantes de Medicina pero no en los estudiantes de otras carreras de la salud. Rev Med Chil 145: 1184-1192. doi: 10.4067\/s0034-98872017000901184.<\/li>\n<li>Bahamondes F, Flores E, Cattaneo G, Bruna F and Conget P. (2017) Omental adipose tissue is more efficient than subcutaneous adipose tissue as Mesenchymal Stem Cell source. BMC Vet Res 13: 166. doi: 10.1186\/s12917-017-1053-0.<\/li>\n<li>De Mayo T, Conget P, Becerra-Bayona S, Sossa CL, Galvis V and Arango-Rodriguez M. (2017) The role of bone marrow mesenchymal stromal cell derivatives in skin wound healing in diabetic mice. PLoS ONE. 12(6):e0177533. doi: 10.1371\/journal.pone.0177533.<\/li>\n<li>Solarte V, Conget P, Vernot JP, Rosas J, Rivera Z, Garc\u00eda J and Arango-Rodriguez M. (2017) A tetrameric peptide derived from bovine lactoferricin as a potential therapeutic tool for oral squamous cell carcinoma: A preclinical model. PLoS One 12(3): e0174707. doi:10.1371\/journal.pone.0174707.<\/li>\n<li>Bruna F, Arango-Rodr\u00edguez M, Plaza A, Espinoza I and Conget P. (2017) The administration of multipotent stromal cells at precancerous stage precludes tumor growth and epitelial<\/li>\n<li>dedifferentiation of oral squamous cell carcinoma. Stem Cell Res 18: 5-13. doi:10.1016\/j.scr.2016.11.016.<\/li>\n<li>Rojo, D.; Conget, P. Cell-free derivatite from mesenchymal stem cells prevents peritoneal adhesions formation. Cytotherapy. 2016 Jun. http:\/\/dx.doi.org\/10.1016\/j.jcyt.2016.03.141<\/li>\n<li>Tekin N., Omidvar N., Morris T.P., Conget P., Bruna F., Timar B., Gagyi E., Basak R., Naik O., Auewarakul C., Sritana N., Levy D., Cerci J.J., Bydlowski S.P., Pereira J., Dimamay M.P., Natividad F., Chung J.-K., Belder N., Kuzu I., Paez D., Dondi M., Carr R., Ozdag H., Padua R.A. Protocol for qRT-PCR analysis from formalin fixed paraffin embedded tissue sections from diffuse large b-cell lymphoma: Validation of the six-gene predictor score. Oncotarget. 2016 Nov. Doi: 10.18632\/oncotarget.13066<\/li>\n<li>Bruna F., Contador D., Conget P., Erranz B., Sossa C.L., Arango-Rodr\u00edguez M.L. Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes. Stem Cells International . 2016. Doi: 10.1155\/2016\/1461648<\/li>\n<li>Robert Carr, Hilal Ozdag, Nilgun Tekin, Timothy Morris, Paulette Conget, Flavia Bruna, Botond Timar, Eva Gagyi, Ranjan Basak, Omkar Naik, Chirayu, Auewarakul, Narongrit Srithana, Mark Pierre Dimamay, Filipinas Natividad, June-Key Chung, Nevin Belder, Isinsu Kuzu, Nader Omidvar, Diana Paez &amp; Rose Ann Padua. The effect of biological heterogeneity on RCHOP treatment outcome in diffuse large B-cell lymphoma across five international regions. Leukemia &amp; Lymphoma. 2016 Oct. Doi: 10.1080\/10428194.2016.1231308<\/li>\n<li>Ezquer F., Bruna F., Calligaris S., Conget P., Ezquer M. Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease. World Journal of Gastroenterology. 2016 Ene: 24-36. Doi: 10.3748\/wjg.v22.i1.24<\/li>\n<li>Soledad Vera, Luz Maria Pozo, Ren\u00e9 Lopez, Joaquin Diaz and Paulette Conget. The Plasma is a Suitable Sample for Moderate Magnesium Deficiency Assessment but the Poor Accuracy of Colorimetric Technique Limits its Use. Annals of Clinical and Laboratory Research. 2016 May.<\/li>\n<li>Ezquer M., Urzua C.A., Montecino S., Leal K., Conget P., Ezquer F. Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice. Stem Cell Res Ther. 2016. Doi\u00a0 10.1186\/s13287-016-0299-y<\/li>\n<li>Ezquer F, Gatica M, Arredondo V, Giraud-Billoud M, Conget P, Ezquer M. Mesenchymal Stem cells prevented the progression of diabetic nephropathy, improved renal function and microvascular architecture in a chronic model of type 1 diabetes mellitus. Cytotherapy. 2015 Jun;17(6):S66-S.<\/li>\n<li>Montecino S, Leal K, Urzua C, Ezquer M, Conget P, Ezquer F. Intravitreal administration of multipotent mesenchymal stromal cells increases neurotrophic factors levels, reduces oxidative damage and prevents retinal neuronal cell loss in diabetic mice. Cytotherapy. 2015 Jun;17(6):S66-S7<\/li>\n<li>Could cancer and infection be adverse effects of mesenchymal stromal cell therapy? Arango-Rodriguez ML, Ezquer F, Ezquer M, Conget P. World J Stem Cells. 2015 Mar 26;7(2):408-417. Review. PMID:25815124<\/li>\n<li>Contador D, Ezquer F, Espinosa M, Arango-Rodriguez M, Puebla C, Sobrevia L, Conget P. Dexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells. Exp Biol Med (Maywood). 2015 Jan 16. pii:1535370214566565. [Epub ahead of print] PMID:25595190[PubMed \u2013 as supplied by publisher]<\/li>\n<\/ul>\n<p><strong>Libros<\/strong><\/p>\n<ul>\n<li>Biehl C, Conget P, Honorato MJ y Santacruz J. (2014) Modelo Educativo carrera de Medicina.\u00a0UDD, Chile.<\/li>\n<li>Allers C, Conget P, Repetto G y Naves R. (2003) 50 a\u00f1os del descubrimiento de la doble h\u00e9lice\u00a0del ADN. UDD, Chile.<\/li>\n<\/ul>\n<p><strong>Cap\u00edtulos de libros<\/strong><\/p>\n<ul>\n<li>Conget P. (2016) Clase al rev\u00e9s: Estudiante habla, profesor escucha. En 17 equipos muestran sus\u00a0innovaciones en docencia. UDD, Chile.<\/li>\n<li>Ezquer F, Ezquer M and Conget P. (2013) Stem cells for the treatment of patients with Type 1\u00a0Diabetes Mellitus. En \u201cType 1 Diabetes: causes, treatment and potentials, complications. Nova\u00a0Publisher, Estados Unidos.<\/li>\n<li>Conget P y SantaCruz J. (2008) Programa Puente, FM CAS-UDD en Innovaci\u00f3n Made in Chile\u00a02008. 50 casos ejemplares en educaci\u00f3n. Fundaci\u00f3n Pa\u00eds Digital y C\u00e1mara de Comercio de\u00a0Santiago. Santiago, Chile.<\/li>\n<li>Minguell JJ, Erices A, Conget PA, Sierralta WD, Rojas CV, Allers C, Benavente C, Fierro F, Rivera F.\u00a0(2003) Mesenchymal (uncommitted) stem cells. En \u201cMesenchymal stem cells: biology and\u00a0potencial clinical uses.\u201d Editado por Ministerio de Sanidad y Consumo, y Fundaci\u00f3n Valenciana\u00a0de Estudios Avanzados. Madrid, Espa\u00f1a.<\/li>\n<\/ul>\n<p><strong>Manuales<\/strong><\/p>\n<ul>\n<li>Bloomfield J, Conget P, Maturana A, Repetto G, Ronco R y SantaCruz J. (2007) Metodolog\u00edas de ense\u00f1anza-aprendizaje aplicables a la educaci\u00f3n m\u00e9dica. Santiago, Chile.<\/li>\n<\/ul>\n<p><strong>Patentes<\/strong><\/p>\n<ul>\n<li>Conget P y Contador D. \u201cComposici\u00f3n que comprende un glucocorticoide y una tiazolinediona para inducir diferenciaci\u00f3n adipog\u00e9nica completa de c\u00e9lulas madre de mam\u00edferos\u201d. PCT\/CL2012\/000076 (publicada)<\/li>\n<li>Conget P y Contador D. \u201cUso de una combinaci\u00f3n de glucocorticoide y una tiazolinediona para inducir diferenciaci\u00f3n adipog\u00e9nica de c\u00e9lulas madre de mam\u00edferos\u201d. CL02642 (retirada)<\/li>\n<\/ul>\n<p><strong>Gu\u00edas<\/strong><\/p>\n<ul>\n<li>Ejercicios para cursos de pregrado: Qu\u00edmica, Bioqu\u00edmica, Biolog\u00eda Molecular, Celular e\u00a0Inmunolog\u00eda. Facultad de Medicina Cl\u00ednica Alemana-Universidad del Desarrollo.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n"},"identifier":"330d6fcd526977525dc57c030c00d2ba855f683b","has_credential":[],"given_name":"Paulette","family_name":"Conget, PhD","name":"Paulette Conget, PhD","job_title":"","telephone":"","note":"Licenciado en Bioqu\u00edmica, P. U. Cat\u00f3lica de Chile. Doctor en Ciencias, menci\u00f3n Biolog\u00eda Molecular y Celular, U. de Chile. Licenciado en Educaci\u00f3n, U. del Desarrollo. 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