Enfermedad cerebrovascular

Las investigaciones llevadas a cabo son preferentemente nuevas estrategias de tratamiento y procesos de atención en infarto y hemorragia cerebral.

ESTUDIO ACT-GLOBAL

Dominios del estudio ACT-GLOBAL:

ENCHANTED 3: https://www.clinicaltrials.gov/study/NCT06352619

ACT-WHEN https://clinicaltrials.gov/study/NCT06320431

INTERACT5 https://clinicaltrials.gov/study/NCT06763055

ESTUDIO OPTIMIST

VER ENLACES DE LAS PUBLICACIONES

• The main Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMISTmain): Protocol for a Pragmatic, Stepped Wedge, Cluster Randomized Controlled Trial. Cerebrovasc Dis.2024;53(5):635-642.
• Implementation of Low-Intensity Thrombolysis Monitoring Care in Routine Practice: Process Evaluation of the Optimal Post rtPA-IV Monitoring in Acute Ischemic Stroke Study in the USA. Cerebrovasc Dis. 2025;54(1):96-104.
• Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial.
• Implementation of Low-Intensity Thrombolysis Monitoring Care in Routine Practice: Process Evaluation of the Optimal Post rtPA-IV Monitoring in Acute Ischemic Stroke Study in the USA. Cerebrovasc Dis. 2025;54(1):96-104. Doi: 10.1159/000538136. Epub 2024 Mar 5. PMID: 38442704.
• OPTIMISTmain Investigators. Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial. Lancet. 2025 May 31;405(10493):1909-1922. Doi: 10.1016/S0140-6736(25)00549-5. Epub 2025 May 21. PMID: 40412428.

ESTUDIO JOIN

ESTUDIO INTERACT 3

PUBLICACIONES

• The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial. Lancet. 2023 Jul 1;402(10395):27-40.
• Effects of blood pressure lowering in relation to time in acute intracerebral haemorrhage: a pooled analysis of the four INTERACT trials.
• Surgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 study.
• Intracerebral haemorrhage management practices and adherence to the INTERACT3 care bundle in Latin America: Results from an international survey. J Stroke Cerebrovasc Dis. 2025 Oct;34(10):108419. doi: 10.1016/j.jstrokecerebrovasdis.2025.108419. Epub 2025 Aug 11. PMID: 40803586.
• Mediation Analysis to Identify Individual Component Effects of the Care Bundle to Improve Functional Outcome After ICH in the INTERACT3 Study. Neurology. 2025 Oct;105(7):e214070. doi: 10.1212/WNL.0000000000214070. Epub 2025 Sep 12. PMID: 40939125.
• LATAM INTERACT3 Consensus Statement Panel. Recommendations for Implementing the INTERACT3 Care Bundle for Intracerebral Hemorrhage in Latin America: Results of a Delphi Method. Cerebrovasc Dis. 2025;54(3):363-370. doi: 10.1159/000540038. Epub 2024 Jul 4. PMID: 38964290; PMCID: PMC12136603.

JANSSEN

PROSPECT