Paula Muñoz - Laboratorio de Salud Poblacional

Directora Centro de Estudios Clínicos
Licenciatura en Medicina, Universidad de los Andes.
Médico Cirujano, Universidad de los Andes.
Postgrado en Neurología, Universidad de Valparaíso.
Pasantía Servicio de Neurología, Unidad de Tratamiento Neurovascular y Rehabilitación, Groupe Hospitalier Lariboisière – Fernand-Widal, Paris, Francia (2008).
Pasantía Unidad de Neurología Vascular Clínica Alemana de Santiago (2009).
Fellowship en Neurología Vascular, Clínica Alemana-Universidad del Desarrollo (2011-2010).
2013 – 2016 PhD – Doctor in Philosophy (Medicine), University of Sydney, Sydney, Australia y PhD student, The George Institute for Global Health, Sydney, Australia. Tesis: Head Positioning and Other Strategies in Stroke Care (2013-2016).
Integrante de Comité Ético Científico de la Facultad de Medicina Clínica Alemana Universidad del Desarrollo desde 2017
Honorary Senior Fellow, The George Institute for Global Health, desde 2017.
Conjoint Senior Lecturer, University of New South Wales

Experiencia en investigación

Member of Steering Committee and Investigator, Statin Treatment for COVID-19 to optimise neurological recovery Stronger, PI: Craig Anderson. (2021-2023)
Principal Investigator of the FONDECYT Regular 2018 project, ID: 1181238, Genomics of Cervical Artery Dissection: A comprehensive characterization of microRNA expression and genetic polymorphisms
Associate Investigator of the FONIS 2019 project, ID: SA19I0118, Evaluation of a cognitive training therapy based on stimulation of brain oscillations in patients with Mild Cognitive Impairment through a randomized clinical trial
Research grant as associate investigator holder, Joint Funded Initiatives Full MR/T005009/1. Grant title: MICA: The third, Intensive care bundle with blood pressure reduction in acute cerebral haemorrhage (INTERACT3) trial; 2019-2022
Part of the Steering Committee for the The Optimal Post rTPA-iv Monitoring in Ischaemic Stroke OPTIMIST trial, since 2019. Principal investigators: Craig Anderson and Victor Urrutia
Regional Leader for Latin America and local site investigator at Clinica Alemana de Santiago of the INTEnsive care bundle with blood pressure Reduction in Acute Cerebral haemorrhage Trial INTERACT3 trial, since 2018. Principal investigator: Craig Anderson
Regional Project Manager in the Regional Coordinating Center for South America, for HeadPoST Head Position in Stroke Trial, from 2014 to 2017. The George Institute for International Health University of Sydney, Australia, Principal investigator: Craig Anderson
Part of Steering Committee for HeadPoST PILOT study Head Position in Stroke Trial from 2013 to 2016. Clínica Alemana de Santiago and The George Institute for International Health University of Sydney, Australia, Principal investigator: Verónica Olavarría
Study coordinator of HeadPoST PILOT trial at Royal Prince Alfred Hospital, Sydney, Australia from 2013 to 2014
Local Principal Investigator in Clínica Alemana de Santiago for the study TRanscranial Ultrasound Imaging for The Evaluation of Hematoma Expansion and Neurologic Deterioration in Patients with Acute IntraCerebral Hemorrhage TREND ICH, Principal Investigators: Octávio Marques Pontes Neto, and Francisco Antunes Dias, Ribeirao Preto, Brazil during 2017.
Regional and Local Coordinator at Clínica Alemana of Santiago of INTERACT 2 Study The second intensive blood pressure in acute cerebral haemorrhage Reduction trial, from 2011 to 2012, Sponsor: The George Institute for International Health University of Sydney, Australia, Principal Investigator: Craig Anderson PhD FRACP.
Study investigator in INTERACT 2 The second intensive blood pressure in acute cerebral haemorrhage Reduction trial, from 2010 to 2012, Sponsor: The George Institute for International Health University of Sydney, Australia, Principal Investigator: Craig Anderson.

Study investigator for the study Record of the evolution of patients with TIA and cerebrovascular disease CLOPI_R_01789 OPTIC, years 2007 to 2010. Sponsor: Sanofi-Aventis, Study Director: Dr. Pascale Blondin, Chairman Steering Committee: Dr. Pierre Amarenco.
Regional Project Manager del Centro de Coordinación Regional para Sudamérica del Estudio HeadPoST (Head Position in Stroke Trial) años 2014-2017. Patrocinador: The George Institute for International Health University of Sydney, Australia, Investigador principal: Craig Anderson PhD FRACP
Integrante del Steering Committee del Estudio HeadPoST PILOTO (Head Position in Stroke Trial) años 2013-2016. Patrocinadores: Clínica Alemana de Santiago y The George Institute for International Health University of Sydney, Australia, Investigador principal: Verónica Olavarría, MD
Coordinadora local del Estudio HeadPoST PILOTO (Head Position in Stroke Trial) en el Hospital Royal Prince Alfred, Sydney, Australia años 2013-2014. Patrocinadores: Clínica Alemana de Santiago y The George Institute for International Health University of Sydney, Australia, Investigador principal: Verónica Olavarría MD
Coordinadora regional y de Clínica Alemana de Santiago del Estudio INTERACT 2 “The second intensive blood pressure reduction in acute cerebral haemorrhage trial”, 2011-2012, Patrocinador: The George Institute for International Health University of Sydney, Australia, Investigador principal: Craig Anderson PhD FRACP
Investigadora y coordinadora del Estudio INTERACT 2 “The second intensive blood pressure reduction in acute cerebral haemorrhage trial”, 2010-2012, Patrocinador: The George Institute for International Health University of Sydney, Australia, Investigador principal: Craig Anderson PhD FRACP.
Investigadora Estudio OPTIC CLOPI_R_01789, “Registro de evolución de pacientes con TIA y enfermedad cerebrovascular”, años 2007 a 2010. Patrocinador: Sanofi-Aventis, Directora del estudio: Dra. Pascale Blondin, Presidente Comité Directivo: Dr. Pierre Amarenco
Tesis de título Neurología adultos Universidad de Valparaíso: “Prevención secundaria en pacientes con accidente cerebrovascular isquémico. Estudio prospectivo. Hospital Carlos Van Buren”, tutor Dr. Claudio Sacks.

Publicaciones

Wang X, Moullaali TJ, Ouyang M, Billot L, Sandset EC, Song L, Delcourt C, Hackett ML, Watkins CL, Robinson TG, Yang J, Lavados PM, Brunser A, Olavarría VV, Muñoz-Venturelli P, Arima H, Middleton S, Pontes-Neto OM, Pandian JD, Rogers K, Anderson CS. Influence of Including Patients with Premorbid Disability in Acute Stroke Trials: The HeadPoST Experience. Cerebrovasc Dis. 2021;50(1):78-87. doi: 10.1159/000512608. Epub 2021 Jan 12. PMID: 33434907
Ouyang M, Billot L, Song L, Wang X, Roffe C, Arima H, Lavados PM, Hackett ML, Olavarría VV, Muñoz-Venturelli P, Middleton S, Pontes-Neto OM, Lee TH, Watkins CL, Robinson TG, Anderson CS. Prognostic significance of early urinary catheterization after acute stroke: Secondary analyses of the international HeadPoST trial. Int J Stroke. 2021 Feb;16(2):200-206. doi: 10.1177/1747493020908140. Epub 2020 Feb 19. PMID: 32075569
Pablo M Lavados, Lorena Hoffmeister, Ana M Moraga, Angelica Vejar, Carolina Vidal, Constanza Gajardo, Bernardita Portales, Daniela San Martín, Eduardo Lopez, Alexis Rojo, Veronica V Olavarria, Juan Almeida, Alejandro M Brunser, Paula Muñoz Venturelli, Violeta Diaz, Arnold Hoppe, Claudio Sacks. Incidence, risk factors, prognosis, and health-related quality of life after stroke in a low-resource community in Chile (ÑANDU): a prospective population-based study Lancet Glob Health 2021; 9: e340–51Published Online January 7, 2021 https://doi.org/10.1016/S2214-109X(20)30470-8
Ouyang M, Muñoz-Venturelli P, Billot L, Wang X, Song L, Arima H, Lavados PM, Hackett ML, Olavarría VV, Brunser A, Middleton S, Pontes-Neto OM, Lee TH, Watkins CL, Robinson T, Anderson CS. Low blood pressure and adverse outcomes in acute stroke: HeadPoST study explanations. J Hypertens. 2021 Feb 1;39(2):273-279. doi: 10.1097/HJH.0000000000002649. PMID: 32897905
Ouyang M, Boaden E, Arima H, Lavados PM, Billot L, Hackett ML, Olavarría VV, Muñoz-Venturelli P, Song L, Rogers K, Middleton S, Pontes-Neto OM, Lee TH, Watkins C, Robinson T, Anderson CS; HeadPoST Investigators. Dysphagia screening and risks of pneumonia and adverse outcomes after acute stroke: An international multicenter study Int J Stroke. 2020 Feb;15(2):206-215. doi: 10.1177/1747493019858778. Epub 2019 Jun 21. PMID: 31226922
Brunser AM, Mazzon E, Cavada G, Mansilla E, Rojo A, Almeida J, Olavarría VV, Muñoz-Venturelli P, Lavados PM. Low dosis of alteplase, for ischemic stroke after Enchanted and its determinants, a single center experience. Arq Neuropsiquiatr. 2020 Nov;78(11):681-686. doi: 10.1590/0004-282X20200048. PMID: 33331463.
Brunser AM, Mazzon E, Muñoz P, Hoppe A, Lavados PM, Rojo A, Navia VH, Cavada G, Olavarría VV, Mansilla E. Determinants of door to needle time for intravenous thrombolysis in acute ischemic stroke Rev Med Chile 2020; 148: 1090-1095.
Menglu Ouyang, Yao Zhang, Xia Wang, Lili Song, Laurent Billot, Thompson Robinson, Pablo M. Lavados, Hisatomi Arima, Maree L. Hackett, Verónica V. Olavarría, Paula Muñoz-Venturelli, Sandy Middleton, Caroline L. Watkins, Octavio M. Pontes-Neto, Tsong-Hai Lee, Alejandro M. Brunser, Craig S. Anderson. Quantifying regional variations in components of acute stroke unit (ASU) care in the international HeadPoST study. Journal of the Neurological Sciences Volume 419, 15 December 2020. doi: https://doi.org/10.1016/j.jns.2020.117187
Alejandro M. Brunser , Pablo M. Lavados, Gabriel Cavada, Paula Muñoz‐Venturelli, Verónica V. Olavarría, Victor Navia, Eloy Mansilla, Violeta Díaz. Transcranial Doppler as a predictor of ischemic events in vertebral artery dissection. Journal of Neuroimaging Aug 2020 doi: https://doi.org/10.1111/jon.12773
Brunser A, Ouyang M, Arima H, Lavados PM, Robinson T, Muñoz-Venturelli P, Olavarría VV, Billot L, Hackett ML, Song L, Middleton S, Pontes-Neto O, Lee TH, Watkinsn C, Anderson CS. No benefit of flat head positioning in early moderate–severe acute ischaemic stroke: a HeadPoST study subgroup análisis Stroke and Vascular Neurology 2020; svn-2020-000387. doi: 10.1136/svn-2020-000387
E. Mazzon, D.Rocha, A.M.Brunser, C.De la Barra, X.Stecher, T.Bernstein, P.Zúñiga, V.Díaz, G.Martínez, P.Muñoz Venturelli. Cervical Artery Dissections with and without stroke, risk factors and prognosis: a Chilean prospective cohort. Journal of Stroke and Cerebrovascular Diseases Volume 29, Issue 8, August 2020, https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104992
Carcel C, Wang X, Sandset E, Delcourt C, Arima H, Lindley R, Hackett ML, Lavados P, Robinson TG, Muñoz Venturelli P, Olavarría VV, Brunser A, Berge E, Chalmers JP, Woodward M, Anderson CS. Sex differences in treatment and outcome after stroke: Pooled analysis including 19,000 participants. Neurology. 2019 Dec 10;93(24):e2170-e2180. doi: 10.1212/WNL.0000000000008615
Muñoz Venturelli P, Li X, Middleton S, Watkins C, Lavados PM, Olavarría VV, Brunser A, Pontes-Neto O, Santos TEG, Arima H, Billot L, Hackett ML, Song L, Robinson T, Anderson CS, HeadPoST Investigators. Impact of Evidence-Based Stroke Care on Patient Outcomes: A Multilevel Analysis of an International Study. J Am Heart Assoc. 2019 Jul 2;8(13):e012640. DOI: 10.1161/JAHA.119.012640
Ouyang M, Boaden E, Arima H, Lavados PM, Billot L, Hackett ML, Olavarría VV, Muñoz-Venturelli P, Song L, Rogers K, Middleton S, Pontes-Neto OM, Lee TH, Watkins C, Robinson T, Anderson CS, HeadPoST Investigators. Dysphagia screening and risks of pneumonia and adverse outcomes after acute stroke: An international multicenter study. Int J Stroke. 2019 Jun 21:1747493019858778. doi: 10.1177/1747493019858778.
Venturelli PM, Appleton JP, Anderson CS, Bath PM. Acute Treatment of Stroke (Except Thrombectomy). Curr Neurol Neurosci Rep. 2018 Sep 18;18(11):77. doi: 10.1007/s11910-018-0883-x.
Brunser AM, Ibañez-Arenas R, Larico M, Mansilla E, Almeida J, Olavarría VV, Muñoz P, Rojo A, Cavada G, Lavados PM. Yield of Echocardiography in the Evaluation of Cerebral Ischemic Events: A Single Center Cohort Study J Stroke Cerebrovasc Dis. 2018 Nov 22. pii: S1052-3057(18)30622-0. doi: 10.1016/j.jstrokecerebrovasdis.2018.10.042.
Brunser AM, Cavada G, Venturelli PM, Olavarría V, Rojo A, Almeida J, Díaz V, Hoppe A, Lavados P. Diffusion-weighted imaging determinants for acute ischemic stroke diagnosis in the emergency room Neuroradiology. 2018 May 22. doi: 10.1007/s00234-018-2029-x.

CS Anderson, H. Arima, P. Lavados, L. Billot, M.L. Hackett, V.V. Olavarría, P. Muñoz Venturelli, A. Brunser, B. Peng, L. Cui, L. Song, K. Rogers, S. Middleton, J.Y. Lim, D. Forshaw, C.E. Lightbody, M. Woodward, O. Pontes‑Neto, H.A. De Silva, R.-T. Lin, T.-H. Lee, J.D. Pandian, G.E. Mead, T. Robinson, and C. Watkins, for the HeadPoST Investigators and Coordinators. Cluster randomized, Cross-over trial of Head Positioning in Acute Stroke N Engl J Med. 2017 Jun 22;376(25):2437-2447.
Verónica V Olavarría, Pablo M Lavados, Paula Muñoz-Venturelli, Francisca González, Javier Gaete, Sheila Martins, Hisatomi Arima, , Craig S Anderson, Alejandro M Brunser. Flat-head positioning increases cerebral blood flow in anterior circulation acute ischemic stroke. A cluster randomized phase IIb trial. Int J Stroke. 2017 Jan 1:1747493017711943.
Laurent Billot, Mark Woodward, Hisatomi Arima, Maree L Hackett, Paula Muñoz Venturelli, Pablo M Lavados, Alejandro Brunser, Bin Peng, Liying Cui, Lily Song, Stephane Heritier, Stephen Jan, Sandy Middleton, Verónica V Olavarría, Joyce Lim, Thompson Robinson, Octavio Pontes-Neto, Caroline Watkins, Craig S Anderson. Statistical analysis plan for the Head Position in Stroke Trial (HeadPoST): An international cluster cross-over randomized trial Int J Stroke. 2017 Aug;12(6):667-670.
Paula Muñoz-Venturelli, Thompson Robinson, Pablo M. Lavados, Verónica V. Olavarría, Hisatomi Arima, Laurent Billot, Maree L. Hackett, Joyce Y. Lim, Sandy Middleton, Octavio Pontes-Neto, Bin Peng, Liying Cui, Lily Song, Gillian Mead, Caroline Watkins, Ruey-Tay Lin, Tsong-Hai Lee, Jeyaraj Pandian, H. Asita de Silva, Craig S. Anderson. Regional variation in acute stroke care organisation. J Neurol Sci. 2016 Dec 15;371:126-130
Brunser AM, Lavados PM, Hoppe A, Muñoz-Venturelli P, Sujima E, López J,Mansilla E, Cárcamo D, Díaz V. Transcranial Doppler as a Predictor of Ischemic Events in Carotid Artery Dissection. J Neuroimaging. 2017 Mar;27(2):232-236. doi:10.1111/jon.12379. Epub 2016 Aug 5. PubMed PMID: 27491878
Paula Muñoz-Venturelli, Alejandro M. Brunser, Javier Gaete, Sergio Illanes, Javiera López, Verónica V. Olavarría, Andrés Reccius, Pablo Brinck, Francisca González, Gabriel Cavada, Pablo M. Lavados. Reliability of Transcranial Doppler with M-mode Ultrasound in Middle Cerebral Artery Measurement. Journal of medical ultrasound, online JAN-4-2017, https://doi.org/10.1016/j.jmu.2016.12.001
Paula Muñoz Venturelli, Xia Wang, Darin B. Zahuranec, Pablo M Lavados, Christian Stapf, Richard Lindley, Candice Delcourt, John Chalmers, Craig S. Anderson, Thompson G. Robinson, for the INTERACT2 Investigators. Withdrawal of active treatment after intracerebral haemorrhage in the INTERACT2 study. Age and Ageing 2017 Mar 1;46(2):329-332. doi: 10.1093/ageing/afw187. PubMed PMID:27831492
Katja E. Wartenberg, Xia Wang, Paula Muñoz-Venturelli, Alejandro A. Rabinstein, Pablo M Lavados, Craig S Anderson, Thompson Robinson. Intensive Care Unit Admission for Patients in the INTERACT2 ICH Blood Pressure Treatment Trial: characteristics, predictors, and outcomes. Neurocrit Care 26 (3), 371-378. 6 2017.
Olavarría VV, Arima H, Anderson CS, Brunser A, Muñoz-Venturelli P, Billot L, Lavados PM; HEADPOST Pilot Investigators. Statistical analysis plan of the head position in acute ischemic stroke trial pilot (HEADPOST pilot). Int J Stroke. 2016 Oct 14. pii: 1747493016674955.
Muñoz-Venturelli P, Wang X, Lavados PM, Stapf C, Robinson T, Lindley R, Heeley E, Delcourt C, Chalmers J, Anderson CS; INTERACT2 Investigators. Prophylactic heparin in acute intracerebral hemorrhage: a propensity score-matched analysis of the INTERACT2 study. Int J Stroke. 2016 Jul;11(5):549-56.
Saxena A, Anderson CS, Wang X, Sato S, Arima H, Chan E, Muñoz-Venturelli P, Delcourt C, Robinson T, Stapf C, Lavados PM, Wang J, Neal B, Chalmers J, Heeley E; INTERACT2 Investigators. Prognostic Significance of Hyperglycemia in Acute Intracerebral Hemorrhage: The INTERACT2 Study. Stroke. 2016 Mar;47(3):682-8.
Brunser AM, Hoppe A, Muñoz P, Lavados PM, Illanes S, Díaz V, Olavarría VV. Thrombolysis in stroke mimics: Experience in 10 cases. Rev Med Chil. 2016 Oct;144(10):1266-1269. doi: 10.4067/S0034-98872016001000005. PubMed PMID: 28074981.
Brunser AM, Muñoz Venturelli P, Lavados PM, Gaete J, Martins S, Arima H, Anderson CS, Olavarría VV. Head position and cerebral blood flow in acute ischemic stroke patients: Protocol for the pilot phase, cluster randomized, Head Position in Acute Ischemic Stroke Trial (HeadPoST pilot). Int J Stroke. 2016 Feb;11(2):253-9.
Paula Muñoz-Venturelli, Hisatomi Arima, Pablo Lavados, Alejandro Brunser, Bin Peng, Liying Cui, Lily Song, Laurent Billot, Elizabeth Boaden, Maree L. Hackett, Stephane Heritier, Stephen Jan, Sandy Middleton, Verónica V. Olavarría, Joyce Y. Lim, Richard I. Lindley, Emma Heeley, Thompson Robinson, Octavio Pontes-Neto, Lkhamtsoo Natsagdorj, Ruey-Tay Lin, Caroline Watkins, Craig S. Anderson, and for the HeadPoST Collaborative Investigators. Head Position in Stroke Trial (HeadPoST) – sitting-up vs lying-flat positioning of patients with acute stroke: study protocol for a cluster randomised controlled trial. Trials. 2015; 16: 256
Xia Wang, Hisatomi Arima, Jie Yang, Shihong Zhang, Guojun Wu, Mark Woodward, Paula Muñoz-Venturelli, Pablo M Lavados, Christian Stapf, Thompson Robinson, Emma Heeley, Candice Delcourt, Richard I Lindley, Mark Parsons, John Chalmers, Craig S. Anderson; for the INTERACT2 Investigators. Mannitol and outcome in intracerebral hemorrhage: propensity score matched and multivariable INTERACT2 results. Stroke. 2015 Oct;46(10):2762-7.
Muñoz Venturelli P, Olavarría V, González F, Brunser A, Lavados P, Arima H, Anderson CS. Head Position in the Early Phase of Acute Ischemic Stroke: An International Survey of Current Practice. J Stroke Cerebrovasc Dis. 2015 Jul;24(7):1564-9
Alejandro M. Brunser, Pablo M. Lavados, Daniel A. Cárcamo, Arnold Hoppe, Verónica V. Olavarría, Javiera López, Paula Muñoz, Rodrigo Rivas. Accuracy of Power Mode Transcranial Doppler in the Diagnosis of Brain Death. Journal of medical ultrasound. 2015 March Volume 23, Issue 1, Pages 29–33
Olavarría VV, Arima H, Anderson CS, Brunser AM, Muñoz-Venturelli P, Heritier S, Lavados PM. Head position and cerebral blood flow velocity in acute ischemic stroke: a systematic review and meta-analysis. Cerebrovasc Dis. 2014 Jun 28;37(6):401-408.
Brunser A, Hoppe A, Muñoz P, Cárcamo D, Lavados PM, Gaete J, Roldán A, Rivas R. Sonothrombolysis for acute ischemic stroke. Rev Med Chil. 2014 Oct;142(10):1238-44
Muñoz-Venturelli P, Sacks C, Madrid E, Lavados PM. Long-term Adherence to National Guidelines for Secondary Prevention of Ischemic Stroke: A Prospective Cohort Study in a Public Hospital in Chile. J Stroke Cerebrovasc Dis. 2014 Mar;23(3):490-5
Brunser AM, Illanes S, Lavados PM, Muñoz P, Cárcamo D, Hoppe A, Olavarria VV, Delgado I, Díaz V. Exclusion Criteria for Intravenous Thrombolysis in Stroke Mimics: An Observational Study. J Stroke Cerebrovasc Dis. 2013 Oct;22(7):1140-5
Brunser AM, Hoppe A, Illanes S, Díaz V, Muñoz P, Cárcamo D, Olavarria V, Valenzuela M, Lavados P. Accuracy of Diffusion-Weighted Imaging in the Diagnosis of Stroke in Patients With Suspected Cerebral Infarct. Stroke. 2013;44:1169-71
Brunser A, Silva C, Cárcamo D, Muñoz P, Hoppe A, Olavarria VV, Díaz V, Abarca J. Transcranial Doppler in a Hispanic-Mestizo population with neurological diseases: a study of sonographic windows and its determinants. Brain Behav 2012;23:231-6
Araya P, Sacks C, Muñoz P, Gigoux JP, García L et al. Vasculitis Primaria de Sistema Nervioso Central, diagnóstico diferencial de demencia subaguda. Rev Méd Chile 2009;137:807-810. Capítulo 62: Dieta y esclerosis múltiple. Claudio Sacks, Pilar Peredo-Orellana, Paula Muñoz-Venturelli. En: Esclerosis múltiple Una mirada ibero – panamericana. Editores Arriagada C, Nogales-Gaete J, Editorial Demos 2008. p. 365-9.