Research Interest:
- My research interest is in host response to viral infection, and how host and pathogens interact. We have use hantavirus infection as a model for studying inter-individual differences that terminate in a different clinical course when infected. Andes orthohantavirus (ANDV) causes hantavirus cardiopulmonary syndrome (HCPS) which is a disease with no cure or vaccine and with a case fatality rate of 30%. Although the Chilean strain of ANDV is the same throughout the country, the clinical spectrum differs depending on individual response, requiring individual treatment. These clinical courses varies from an asymptomatic illness to death for cardiopulmonary shock The unique landscape of having an admixed population in Chile enables us to use genetic and genomic tools that are helping us understand this neglected disease pathophysiology. We are also using immunological approaches to understand host response to ANDV along with studying the virus. Our ultimate goal is to propose novel therapeutic targets and biomarkers of disease severity for HCPS.
- Mi interés en la investigación es la respuesta del hospedero a las infecciones virales, y cómo interactúan el huésped y estos patógenos. Hemos utilizado la infección por hantavirus como un modelo para estudiar las diferencias entre individuos que terminan en un curso clínico diferente cuando se infectan. El ortohantavirus Andes (ANDV) causa el síndrome cardiopulmonar del hantavirus (HCPS), que es una enfermedadsin cura ni vacuna y que tiene una letalidad de 30%. Aunque la cepa chilena de ANDV es la misma en todo el país, el espectro clínico difiere según la respuesta individual, lo que requiere un tratamiento individual. Estos cursos clínicos varían desde una enfermedad asintomática hasta la muerte por shock cardiopulmonar. El paisaje único de tener una población mestiza en Chile nos permite utilizar herramientas genéticas y genómicas que nos ayudan a comprender la patofisiología de esta enfermedad. También estamos utilizando enfoques inmunológicos para comprender la respuesta de los pacientes al ANDV junto con el estudiar al virus y su roedor portador. Nuestro objetivo final es proponer nuevos blancos terapéuticos y biomarcadores de gravedad de la enfermedad para HCPS.
Selected publications
- Clement, J., Ahlm, C., Avšič-Županc, T., Botten, J., Chandran, K., Jonsson,C.B., Kariwa, H., Klingström, J., Klempa, B., Krüger, D.H., Leirs, H., Li, D., Liang, M., Markotić, A.,Papa, A., Schmaljohn, C.S., Tischler, N.D., Ulrich, R.G., Vaheri, A., Vial, C., Yanagihara, R., Maes,P., Meeting report: Eleventh international conference on hantaviruses, Antiviral Research (2020), doi: https://doi.org/10.1016/j.antiviral.2020.104733
- Hemodynamic and Pulmonary Permeability Characterization of Hantavirus Cardiopulmonary Syndrome by Transpulmonary Thermodilution, by René López , Rodrigo Pérez-Araos , Álvaro Salazar, Ana L. Ulloa, Cecilia Vial ,Pablo A. Vial and Jerónimo Graf, Viruses 2019, 11(10), 900; https://doi.org/10.3390/v11100900
- A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile, Fernando Torres-Pérez, R. Eduardo Palma ,Dusan Boric-Bargetto ,Cecilia Vial, Marcela Ferrés ,Pablo A. Vial ,Constanza Martínez-Valdebenito ,Carlos Pavletic, Alonso Parra, Pablo A. Marquet and Gregory J. Mertz, Viruses 2019, 11(9), 848; https://doi.org/10.3390/v11090848
- Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome, René López, Cecilia Vial , Jerónimo Graf, Mario Calvo, Marcela Ferrés , Gregory Mertz , Analía Cuiza , Begonia Agüero, Dante Aguilera, Diego Araya, Ignacia Pailamilla ,Flavia Paratori,Víctor Torres-Torres,Pablo A Vial and Hantavirus Study Group in Chile, Viruses 2019, 11(8), 693; https://doi.org/10.3390/v11080693
- Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection, Grazielle Esteves Ribeiro ,Luis Edgardo Leon ,Ruth Perez, Analia Cuiza ,Pablo Agustin Vial, Marcela Ferres ,Gregory J. Mertz and Cecilia Vial *, Viruses 2019, 11(8), 680; https://doi.org/10.3390/v11080680
- Factores de riesgo sociodemográficos del síndrome cardiopulmonar por hantavirus, *Cecilia Vial C., Francisca Valdivieso R., Analía Cuiza V., Iris Delgado B., Grazielle Ribeiro E.,Elena Llop R., Marcela Ferrés G. Gabriela M. Repetto L., Raúl Riquelme, Maria Luisa Rioseco , Mario Calvo, Gregory Mertz, Pablo A. Vial C., Revista Chilena de Infectologia, 36 (4):428., 2019, http://dx.doi.org/10.4067/S0716-10182019000400428
- A Single-Nucleotide Polymorphism of αVβ3 Integrin Is Associated with the Andes Virus Infection Susceptibility, Constanza Martínez-Valdebenito, Jenniffer Angulo, Nicole Le Corre, Claudia Marco, Cecilia Vial, Juan Francisco Miquel, Jaime Cerda, Gregory Mertz, Pablo Vial, Marcelo Lopez-Lastra, Marcela Ferrés, Viruses 2019 11 (2):169, https://doi.org/10.3390/v11020169
- Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert, Lucas Vicuna, Mario I. Fernandez, Cecilia Vial, Patricio Valdebenito, Eduardo Chaparro, Karena Espinoza, Annemarie Ziegler, Alberto Bustamante and Susana Eyheramendy, Genome Biol. Evol. 2019 11(9):2468–2479. https://doi.org/10.1093/gbe/evz172
- Cecilia Vial*, Constanza Martinez-Valdebenito, Susana Rios, Jessica Martinez, Pablo A. Vial, Marcela Ferres, Juan C.Rivera, Ruth Perez, Francisca Valdivieso, Molecular method for the detection of Andes hantavirus infection: validation for clinical diagnostics, DMID, 2016, 84 (1): 36–39.
- Susana Eyheramendy, Felipe I Martinez, Federico Manevy, Cecilia Vial*, Gabriela M Repetto, Genetic structure characterization of Chileans reflects historical immigration patterns, Nat Comm, 2015, 6:6472: 1-10, https://doi.org/10.1038/ncomms7472
- Lay-Son Guillermo, Espinoza Karena, Vial Cecilia, Rivera Juan Carlos, Guzmán Maria Luisa, Repetto Gabriela, Chromosomal microarrays testing in children with developmental disabilities and congenital anomalies: clinical experience, 2015, Jornal de Pediatria.91 (2): 189-195. https://doi.org/10.1016/j.jped.2014.07.003
- A nonrandomized multicenter trial of human immune plasma for treatment of hantavirus cardiopulmonary syndrome by ANDV, Vial Pablo, Valdivieso Francisca, Calvo Mario, Rioseco Maria Luisa, Riquelme Raúl, Araneda Andres, Tomicic Vinko, Graf Jerónimo, Paredes Laura, Florenzano Matias, Bidart Teresa, Cuiza Analia, Marco Claudia, Hjelle Brian, Ye Chunyan, Hanfelt-Goade Diane, Vial Cecilia, Rivera Juan Carlos, Delgado Iris, Mertz Gregory J. Hantavirus Study Group in Chile, Antiviral Therapy, 2014, https://doi.org/10.3851/IMP2875
- Martinez-Valdebenito Constanza, Calvo Mario, Vial Cecilia, Mansilla Rita, Marco Claudia, Palma Eduardo, Vial Pablo, Valdivieso Francisca, Mertz Greg, Ferres Marcela, 2014, Person-to-person household and nosocomial transmission of Andes hantavirus, Southern Chile, 2011, Emerging Infectious Disease, 20 (10): 1629-1636 https://doi.org/10.3201/eid2010.140353
- Pablo A. Vial, Francisca Valdivieso, Marcela Ferres, Raul Riquelme, M. Luisa Rioseco, Mario Calvo, Constanza Castillo, Ricardo Díaz, Luis Scholz, Analia Cuiza, Edith Belmar, Carla Hernandez, Jessica Martinez, Sang-Joon Lee, and Gregory J. Mertz; for the Hantavirus Study Group in Chile* *Cecilia Vial, 2013, High-Dose Intravenous Methylprednisolone for Hantavirus Cardiopulmonary Syndrome in Chile: A Double-Blind, Randomized Controlled Clinical Trial, Clin Infect Disease, 57:943. https://doi.org/10.1093/cid/cit394
- Vial C, Gutierrez J, Santander C, Cabrera D, Brandan E., 2011, Decorin interacts with CTGF/CCN2 through LRR12 inhibiting its biological activity, J Biol Chem;286(27):24242-52
- Cabello-Verrugio, C., Cordova, G., Zuñiga, L., Vial, C., Brandan, E. “Connective Tissue Growth Factor induction by lysophosphatidic acid requires transactivation of Transforming Growth Factor type beta receptors and the JNK pathway”. (2011) Cell. Signaling 23(2):449-457 https://doi.org/10.1016/j.cellsig.2010.10.019
- Nguyen, T.Q., Roestenberg, P., van Nieuwenhoven, F.A., Bovenschen, N., Li, Z., Xu, L., Oliver, N., Aten, J., Joles, J.A., Vial, C., Brandan, E., Lyons, K.M., Goldschmeding, R., 2008, CTGF inhibits BMP-7 Signalling Activity in Diabetic Nephropathy, J Am Soc Nephrol,. 19 (11):2098-107 https://doi.org/10.1681/ASN.2007111261
- Brandan,E.,Cabello-Verrugio,C.,Vial,C., 2008, Novel Regulatory Mechanisms for Proteoglycans Decorin and Biglycan During Muscle and Muscular Dystrophy, Matrix Biol, 27(8): 700-708 https://doi.org/10.1016/j.matbio.2008.07.004
- Vial,C.,Zuñiga,L.M.,Cabello-Verrugio,C.,Cañón,P.,Fadic,R.,Brandan,E., 2007, Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation, J Cell Physiol, 215:410-421 https://doi.org/10.1002/jcp.21324
Proyectos de investigación
- Understading host response to ANDV infection, immunological and transcriptomics approach. 2016 – 2019. Fondecyt Regular 2016
- Collaborative Network On Immunopathogenesis Of Hantavirus Infection. 2018. REDES.
- Unraveling the differences between mild and severe hantavirus infected patients: delineating mechanisms to propose novel therapeutic approaches. 2020. Fondecyt Regular.
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Afiliaciones:
- Miembro de la Sociedad Americana de Genética Humana (ASHG)
- Miembro de la Sociedad de Genética de Chile (SOCHIGEN)