Publicaciones científicas

2019

Arce, M., Pinto, M. P., Galleguillos, M., Muñoz, C., Lange, S., Ramirez, C., Erices, R., Gonzalez, P., Velasquez, E., Tempio, F., López, M. N., Salazar-Onfray, F., Cautivo, K., Kalergis, A. M., Cruz, S., Lladser, A., Lobos-Gonzalez, L., Valenzuela, G., Olivares, N., Sáez, C., Koning, T., Sánchez, F. A., Fuenzalida, P., Godoy, A., Contreras-Orellana, P., Leyton, L., Lugano, R., Dimberg, A., Quest, A. F. G., Owen, G. Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation, CANCERS, Ago 2019, DOI: 10.3390/cancers11081103

Campos, America; Burgos-Ravanal, Renato; Fernanda Gonzalez, Maria; Huilcaman, Ricardo; Lobos Gonzalez, Lorena; Geoffery Quest, Andrew Frederick. Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis, BIOMOLECULES, Ago 2019, DOI: 10.3390/biom9080314

Cruces, P., Erranz, B., Lillo, F., Sarabia-Vallejos, M. A., Iturrieta, P., Morales, F., Blaha, K., Medina, T., Diaz, F., Hurtado, D. E. Mapping regional strain in anesthetised healthy subjects during spontaneous ventilation, BMJ OPEN RESPIRATORY RESEARCH, Feb 2019, DOI: 10.1136/bmjresp-2019-000423

Fitzpatrick, C., Bendek, M. F., Briones, M., Farfan, N., Silva, V. A., Nardocci, G., Montecino, M., Boland, A., Deleuze, J. F., Villegas, J., Villota, C., Silva, V., Lobos-Gonzalez, L., Borgna, V., Barrey, E., Burzio, L., Burzio, V. A. Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors, CELL DEATH & DISEASE, 2019, DOI: 10.1038/s41419-019-1649-3

Hercher, D., Kerbl, M., Schuh, C. M. A. P., Heinzel, J., Gal, L., Stainer, M., Schmidhammer, R., Hausner, T., Redl, H., Nogradi, A., Hacobian, A. Spatiotemporal Differences in GEne Expression Between Motor and Sensory Autografts and Their Effect on Femoral Nerve Regeneration in the Rat, Frontiers in Cellular Neuroscience, 2019, DOI: 10.3389/fncel.2019.00182

Araos, J., Alegria, L., Garcia, P., Cruces, P., Soto, D., Erranz, B., Amthauer, M., Salomon, T., Medina, T., Rodriguez, F., Ayala, P., Borzone, G., Meneses, M., Damiani, F., Retamal, J., Cornejo, R., Bugedo, G., Bruhn, A. ar-Apneic Ventilation Decreases Lung Injury and Fibroproliferation in an ARDS Model with ECMO, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Mar 2019, DOI: 10.1164/rccm.201805-0869OC

Quintanilla, M. E., Ezquer, F., Morales, P., Santapau, D., Berrios-Carcamo, P., Ezquer, M., Herrera-Marschitz, M., Yedy, I. Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options, STEM CELL RESEARCH & THERAPY, 2019, DOI: 10.1186/s13287-019-1304-z

Rosenberger, L., Ezquer, M., Lillo-Vera, F., Pedraza, P. L., Ortuzar, M. I., Gonzalez, P. L., Figueroa-Valdes, A. I., Cuenca, J., Ezquer, F., Khoury, M., Alcayaga-Miranda, F. Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma, SCIENTIFIC REPORTS, Ene 2019, DOI: 10.1038/s41598-018-36855-6

Schuh, C. M. A. P., Aguayo, S., Zavala, G., Khoury, M. Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity, JOURNAL OF EXPERIMENTAL BIOLOGY, Oct 2019, DOI: 10.1242/jeb.208702

Schuh, C. M. A. P., Benso, B., Aguayo, S. Potential Novel Strategies for the Treatment of Dental Pulp-Derived Pain: Pharmacological Approaches and Beyond, FRONTIERS IN PHARMACOLOGY, 2019, DOI: 10.3389/fphar.2019.01068

Schuh, C. M. A. P., Cuenca, J., Alcayaga-Miranda, F., Khoury, M. Exosomes on the border of species and kingdom intercommunication, TRANSLATIONAL RESEARCH, 2019, DOI: 10.1016/j.trs1.2019.03.008

Yedy, I., Quintanilla, M. E., Ezquer, F., Morales, Rivera-Meza, M., Karahanian, E., Ezquer, M., Herrera-Marschitz, M. GEne and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options, GEne therapy, Nov 2019, DOI: 10.1038/s41434-019-0064-9

2018

Sepúlveda P.O., Carrasco E., Tapia L.F., Ramos M., Cruz F., Conget P., Olivares Q.F.B., Cortínez I., Evidence of hysteresis in propofol pharmacodynamics. Anaesthesia. 2018. Doi: 10.1111/anae.14009

Elena Quintanilla, Maria; Morales, Paola; Ezquer, Fernando; Ezquer, Marcelo; Herrera-Marschitz, Mario; Israel, Yedy. Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 2018. Doi: 10.1111/acer.13842

Ezquer F, Quintanilla ME, Morales P, Santapau D, Ezquer M, Kogan MJ, Salas-Huenuleo E, Herrera-Marschitz M, Israel Y. Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking. Addiction Biology. 2018. Doi: 10.1111/adb.12675

Ezquer, F.; De Gregorio, C.; Contador, D.; Santapau, D.; Campero, M.; Ezquer, M. Characterisation of an animal model of type 2 diabetes with potential application in the evaluation of new therapies for diabetic neuropathy. DIABETOLOGIA. 2018.

Balsebre, Arantza; Baez, Maria E.; Martinez, Jessica; Fuentes, Edwar. Matrix solid-phase dispersion associated to gas chromatography for the assessment in honey bee of a group of pesticides of concern in the apicultural field. JOURNAL OF CHROMATOGRAPHY A. 2018. Doi: 10.1016/j.chroma.2018.06.062

De Gregorio, Cristian; Contador, David; Campero, Mario; Ezquer, Marcelo; Ezquer, Fernando. Characterization of diabetic neuropathy progression in a mouse model of type 2 diabetes mellitus. BIOLOGY OPEN. 2018. Doi: 10.1242/bio.036830

Manuel Diaz-Garcia, Victor; Guerrero, Simon; Diaz-Valdivia, Natalia; Lobos-Gonzalez, Lorena; Kogan, Marcelo; Perez-Donoso, Jose Manuel; Quest, Andrew F. G. Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging. INTERNATIONAL JOURNAL OF NANOMEDICINE. 2018. Doi: 10.2147/IJN.S165565

Campos A., Salomon C., Bustos R., Díaz J., Martínez S., Silva V., Reyes C., Díaz-Valdivia N., Varas-Godoy M., Lobos-González L., Quest A.F., Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines. Nanomedicine. 2018. Doi: 10.1177/1947603518786547

Calvo R., Espinosa M., Figueroa D., Pozo L.M., Conget P., Assessment of Cell Viability of Fresh Osteochondral Allografts in N-Acetylcysteine-Enriched Medium. Cartilage. 2018.

Giraud-Billoud M., Fader C.M., Agüero R., Ezquer F., Ezquer M., Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship. Biocell. 2018.

Fernando Ezquer, Paola Morales, María Elena Quintanilla, Daniela Santapau, Carolyne Lespay-Rebolledo, Marcelo Ezquer, Mario Herrera-Marschitz & Yedy Israel. Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes bingedrinkingScientific Reports (2018) 8:4325 | DOI:10.1038/s41598-018-22750-7

Rojo, Daniel; Conget, Paulette. Acellular derivatives of mesenchymal stem cells prevent peritoneal adhesions in an animal model. JOURNAL OF SURGICAL RESEARCH. 2018. Doi: 10.1016/j.jss.2017.11.018

Bruna, Flavia; Plaza, Anita; Arango, Martha; Espinoza, Iris; Conget, Paulette. Systemically administered allogeneic mesenchymal stem cells do not aggravate the progression of precancerous lesions: a new biosafety insight. STEM CELL RESEARCH & THERAPY. 2018. 10.1186/s13287-018-0878-1

Cuenca, Jimena; Le-Gatt, Alice; Castillo, Valentina; Belletti, Jose; Diaz, Macarena; Monica Kurte, G.; Gonzalez, Paz L.; Alcayaga-Miranda, Francisca; Schuh, Christina M. A. P.; Ezquer, Fernando; Ezquer, Marcelo; Khoury, Maroun. The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration. FRONTIERS IN PHYSIOLOGY. 2018. Doi: 10.3389/fphys.2018.00464

Guerrero, Simon; Manuel Diaz-Garcia, Victor; Contreras-Orellana, Pamela; Lara, Pablo; Palma, Sujey; Guzman, Fanny; Lobos-Gonzalez, Lorena; Cardenas, Areli; Rojas-Silva, Ximena; Munoz, Luis; Leyton, Lisette; Kogan, Marcelo J.; Quest, Andrew F. G. Gold nanoparticles as tracking devices to shed light on the role of caveolin-1 in early stages of melanoma metastasis. Nanomedicine. 2018. 10.2217/nnm-2017-0390

Ezquer, F.; Quintanilla, M. E.; Morales, P.; Lespay-Rebolledo, C.; Santapau, D.; Ezquer, M.; Herrera-Marschitz, M.; Israel, Y. ANTI-INFLAMMATORY MESENCHYMAL STEM CELLS AND N-ACETYL CYSTEINE INHIBIT CHRONIC ETHANOL INTAKE AND ABOLISH RELAPSE BINGE DRINKING: PRECLINICAL STUDIES. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 2018.

2017

Copier C.U., León L., Fernández M., Contador D., Calligaris S.D., Circulating miR-19b and miR-181b are potential biomarkers for diabetic cardiomyopathy. SCIENTIFIC REPORTS. 2017. Doi: 10.1038/s41598-017-13875-2

Ezquer F., Quintanilla M.E., Morales P., Ezquer M., Lespay-Rebolledo C., Herrera-Marschitz M., Israel Y., Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats. Addiction Biology. 2017. Doi: 10.1111/adb.12572

Giraud-Billoud M., Ezquer F., Bahamonde J., Ezquer M., Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus. Biocell 2017, 41(1): 1-12

Lazcano X., Villalón F., Vera S., Conget P., The constructivist epistemological belief about scientific knowledge varies according to the year of training in medical students but not in students of other health careers. Revista Medica de Chile. 2017.

Campo-Verde-Arbocco F., López-Laur J.D., Romeo L.R., Giorlando N., Bruna F.A., Contador D.E., López-Fontana G., Santiano F.E., Sasso C.V., Zyla L.E., López-Fontana C.M., Calvo J.C., Carón R.W., Creydt V.P., Human renal adipose tissue induces the invasion and progression of renal cell carcinoma. Oncotarget. 2017. Doi: 10.18632/oncotarget.21666

Conget P., Rojo D., Acellular derivatives of mesenchymal stem cells prevent peritoneal adhesions in an animal model, Journal of Surgical Research, 2018, DOI10.1016/j.jss.2017.11.018

Fernando E. Ezquer, Marcelo E. Ezquer, Jose M. Vicencio & Sebastián D. Calligaris, Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: increasing transplanted cell resistance and increasing tissue receptivity, Cell Adhesion & Migration, Jun 2017, DOI10.1080/19336918.2016.1197480

Israel, Yedy; Elena Quintanilla, Maria; Morales, Paola; Ezquer, Marcelo; Herrera-Marschitz, Mario; Ezquer, Fernando, Alcohol intake: from initiation to maintenance and relapse binge-drinking. Mechanisms and translational opportunities, Alcohol And Alcoholism, Oct 2017

Morales, P.; Ezquer, F.; Quintanilla, M. E.; Lespay-Rebolledo, C.; Santapau, D.; Valdes, J. L.; Kogan, M.; Salas, E.; Herrera-Marschitz, M.; Israel, Y. Anti-Inflammatory Mesenchymal Stem Cell-Derived Spheroids Inhibit Chronic And Relapse-Like Ethanol Intake And Reduce Oxidative Stress, Alcohol And Alcoholism, Oct 2017, DOI10.1093/alcalc/agx074.05

Robert Carr, Hilal Ozdag, Nilgun Tekin, Timothy Morris, Paulette Conget, Flavia Bruna, Botond Timar, Eva Gagyi, Ranjan Basak, Omkar Naik, Chirayu, Auewarakul, Narongrit Srithana, Mark Pierre Dimamay, Filipinas Natividad, June-Key Chung, Nevin Belder, Isinsu Kuzu, Nader Omidvar, Diana Paez & Rose Ann Padua , The effect of biological heterogeneity on RCHOP treatment outcome in diffuse large B-cell lymphoma across five international regions, Leukemia & Lymphoma, Oct 2017, DOI10.1080/10428194.2016.1231308

2016

Rojo, D.; Conget, PCell-free derivatite from mesenchymal stem cells prevents peritoneal adhesions formation. Cytotherapy. 2016 Jun. http://dx.doi.org/10.1016/j.jcyt.2016.03.141

Maximiliano Giraud-Billoud M, Ezquer F, Bahamonde J, Ezquer M. Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus. Biological Research. 2016.

Amaya C., Militello R.D., Calligaris S.D., Colombo M.I. Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation. Traffic. 2016 Nov: 1181-1196. Doi: 10.1111/tra.12431

Tekin N., Omidvar N., Morris T.P., Conget P., Bruna F., Timar B., Gagyi E., Basak R., Naik O., Auewarakul C., Sritana N., Levy D., Cerci J.J., Bydlowski S.P., Pereira J., Dimamay M.P., Natividad F., Chung J.-K., Belder N., Kuzu I., Paez D., Dondi M., Carr R., Ozdag H., Padua R.A. Protocol for qRT-PCR analysis from formalin fixed paraffin embedded tissue sections from diffuse large b-cell lymphoma: Validation of the six-gene predictor score. Oncotarget. 2016 Nov. Doi: 10.18632/oncotarget.13066

Araos J., Alegría L., García P., Damiani F., Tapia P., Soto D., Salomon T., Rodriguez F., Amthauer M., Erranz B., Castro G., Carreño P., Medina T., Retamal J., Cruces P., Bugedo G., Bruhn A. Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome. American Journal of Translation Research. 2016.

Losinno A.D., Sorrivas V., Ezquer M., Ezquer F., López L.A., Morales A. Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule. Cell and Tussue Research .2016 Ago: 425-435. Doi: 10.1007/s00441-016-2386-x

Bruna F., Contador D., Conget P., Erranz B., Sossa C.L., Arango-Rodríguez M.L. Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes. Stem Cells International . 2016. Doi: 10.1155/2016/1461648

Robert Carr, Hilal Ozdag, Nilgun Tekin, Timothy Morris, Paulette Conget, Flavia Bruna, Botond Timar, Eva Gagyi, Ranjan Basak, Omkar Naik, Chirayu, Auewarakul, Narongrit Srithana, Mark Pierre Dimamay, Filipinas Natividad, June-Key Chung, Nevin Belder, Isinsu Kuzu, Nader Omidvar, Diana Paez & Rose Ann Padua. The effect of biological heterogeneity on RCHOP treatment outcome in diffuse large B-cell lymphoma across five international regions. Leukemia & Lymphoma. 2016 Oct. Doi: 10.1080/10428194.2016.1231308

Ezquer F., Bruna F., Calligaris S., Conget P., Ezquer MMultipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease. World Journal of Gastroenterology. 2016 Ene: 24-36. Doi: 10.3748/wjg.v22.i1.24

Soledad Vera, Luz Maria Pozo, René Lopez, Joaquin Diaz and Paulette Conget. The Plasma is a Suitable Sample for Moderate Magnesium Deficiency Assessment but the Poor Accuracy of Colorimetric Technique Limits its Use. Annals of Clinical and Laboratory Research. 2016 May.

Ezquer M., Urzua C.A., Montecino S., Leal K., Conget P., Ezquer FIntravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice. Stem Cell Res Ther. 2016. Doi  10.1186/s13287-016-0299-y

Tekin, N.; Omidvar, N.; Morris, T.; Timar, B.; Gagyi, E.; Conget, P.; Bruna, F.; Basak, R.; Naik, O.; Auewarakul, C. Udomsakdi; Sritana, N.; Levy, D.; Bydlowski, S. P.; Pereira, J.; Dimamay, M. P.; Natividad, F.; Chung, J. K.; Belder, N.; Kuzu, I.; Paez, D.; Dondi, M.; Carr, R.; Ozdag, H.; Padua, R. A. Diffuse large b-cell lymphoma (dlbcl) study reveals biological heterogeneity between ethnically diverse countries; validation of 6-gene prognostic score in an international cohort. Haematologica. 2016.

Fernando E. Ezquer, Marcelo E. Ezquer, Jose M. Vicencio & Sebastián D. Calligaris. Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: increasing transplanted cell resistance and increasing tissue receptivity. Cell Adhesion & Migration. 2016. Doi 10.1080/19336918.2016.1197480

Abrigo J., Rivera J.C., Aravena J., Cabrera D., Simon F., Ezquer F., Ezquer M., Cabello-Verrugio C. High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis. Cell Adhesion & Migration. 2016. doi: 10.1080/19336918.2016.1197480

Israel Y, Ezquer F, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz M. Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats. Alcohol and Alcoholism. 2016. Doi: 10.1093/alcalc/agw068

2015

Diaz F, Erranz B, Donoso A, Salomon T, Cruces P. Influence of tidal volume on pulse pressure variation and stroke volume variation during experimental intra-abdominal hypertension. BMC Anesthesiology. 2015 Sep:22;15.

Ezquer F, Gatica M, Arredondo V, Giraud-Billoud M, Conget P, Ezquer M. Mesenchymal Stem cells prevented the progression of diabetic nephropathy, improved renal function and microvascular architecture in a chronic model of type 1 diabetes mellitus. Cytotherapy. 2015 Jun;17(6):S66-S.

Montecino S, Leal K, Urzua C, Ezquer M, Conget P, Ezquer F. Intravitreal administration of multipotent mesenchymal stromal cells increases neurotrophic factors levels, reduces oxidative damage and prevents retinal neuronal cell loss in diabetic mice. Cytotherapy. 2015 Jun;17(6):S66-S7

Solarte VA, Rosas JE, Rivera ZJ, Arango-Rodriguez ML, Garcia JE, Vernot J-P. A tetrameric peptide derived from bovine lactoferricin exhibits specific cytotoxic effects against oral squamous-cell carcinoma cell lines. Biomed Research International. 2015.

Could cancer and infection be adverse effects of mesenchymal stromal cell therapy? Arango-Rodriguez ML, Ezquer F, Ezquer M, Conget P. World J Stem Cells. 2015 Mar 26;7(2):408-417. Review. PMID:25815124

Ezquer F, Gutiérrez J, Ezquer M, Caglevic C, Salgado HC, Calligaris SD. Mesenchymal stem cell therapy fordoxorubicin cardiomyopathy: hopes and fears. Stem Cell Res Ther. 2015; 6:116.

Contador D, Ezquer F, Espinosa M, Arango-Rodriguez M, Puebla C, Sobrevia L, Conget PDexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells. Exp Biol Med (Maywood). 2015 Jan 16. pii:1535370214566565. [Epub ahead of print] PMID:25595190[PubMed – as supplied by publisher]

Erranz B, Wilhelm J, Riquelme R, Cruces P. Predisposición genética y síndrome de distrés respiratorio agudo pediátrico: nuevas herramientas de estudio genético. Rev Chil Pediatr. 2015; 86(2):73-79.

Ezquer F, Giraud-Billoud M, Carpio D, Cabezas F, Conget P, Ezquer M. Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus. Biomed Res Int. 2015. DOI: 10.1155/2015/164703

Campero M, Ezquer M, Ezquer FNerve Excitability and Structural Changes in Myelinated Axons from Diabetic Mice. Exp Clin Endocrinol Diabetes. 2015 Aug 18. [Epub ahead of print] PMID:26285066

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