Cargo actual
- Subdirector. Centro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana Universidad del Desarrollo.
- Investigador – docente. Facultad de Medicina Clínica Alemana Universidad del Desarrollo.
Docencia
- Profesor. Programa Puente (pre-grado Medicina). Facultad de Medicina Clínica Alemana-Universidad del Desarrollo (desde 2007).
- Profesor. Curso Biología Molecular, Celular e Inmunología (pre-grado Medicina). Facultad de Medicina Clínica Alemana-Universidad del Desarrollo (desde 2007).
- Profesor Invitado. Curso Biotecnología Médica (pre-grado Ingeniería en Biotecnología). Facultad de Ciencias, Universidad de Chile (desde 2009).
- Profesor Invitado. Curso Medicina Regenerativa y Células Troncales (post-grado). Facultas de Medicina. Universidad Nacional de Cuyo (2013).
- Tutor de tesis de pregrado, doctorado y postdoctorado.
Proyectos de investigación
- Opioid addiction and associated cognitive damage: Inhibition by intranasal mesenchymal stem cell secretome administration. Fondecyt Regular 2020.
- Treating the whole not the hole: Administration of acellular derivative from mesenchymal stem cells subjected to a preconditioning stimulus reverts diabetic neuropathy and prevents diabetic foot ulcers in an animal model of type 2 diabetes mellitus (2017-2019). Fondecyt Regular 2016 (cód. 1170712)
- «Modelamiento matemático en medicina. Desarrollo de un algoritmo matemático capaz de predecir cuál es el mejor fármaco biológico para el tratamiento de la neuropatía diabética» (2016-2018). Concurso Interfacultades UDD
- Donor multipotent mesenchymal stromal cells modify the natural evolution of retinal damage in diabetic mice. (2013-2016). Investigador principal. FONDECYT Regular-Chile.
- Producto derivado de células troncales mesenquimáticas favorece regeneración del hígado en individuos con esteatosis sometidos a una cirugía de resección hepática. Co-Director. FONDEF IDEA N° CA13/10088 (2013-2015).
- The etiology of diabetes and/or the stage of diabetic nephropathy modify the renoprotective effect of donor multipotent mesenchymal cells? Co-Investigador. FONDECYT N° 1120133 (2012-2015)
- Identification of cellular and molecular mechanisms behind beta-pancreatic islets regeneration induced by multipotent mesenchymal stromal cells in type 1 diabetic mice. (2009-2011). Investigador principal. FONDECYT iniciación-Chile
- Mecanismos celulares responsables de la prevención del daño renal tras la administración sistémica de células troncales mesenquimáticas a ratones con diabetes mellitus severa. (2009-2010). Investigador principal. Universidad del Desarrollo (Concurso interno, VRA) Chile.
- Instituto Milenio de Dinámica Celular y Biotecnología. Unidad de Entrega y Expresión Génica. Co-Investigador. Iniciativa Científica Milenio ICMP-05-001-F (2007-2011).
Últimas publicaciones
- Quintanilla, M. E., Ezquer, F., Morales, P., Santapau, D., Berrios-Carcamo, P., Ezquer, M., Herrera-Marschitz, M., Yedy, I. Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options, STEM CELL RESEARCH & THERAPY, 2019, DOI: 10.1186/s13287-019-1304-z
- Yedy, I., Quintanilla, M. E., Ezquer, F., Morales, Rivera-Meza, M., Karahanian, E., Ezquer, M., Herrera-Marschitz, M. GEne and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options, GEne therapy, Nov 2019, DOI: 10.1038/s41434-019-0064-9
- Elena Quintanilla, Maria; Morales, Paola; Ezquer, Fernando; Ezquer, Marcelo; Herrera-Marschitz, Mario; Israel, Yedy. Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 2018. Doi: 10.1111/acer.13842
- Ezquer F, Quintanilla ME, Morales P, Santapau D, Ezquer M, Kogan MJ, Salas-Huenuleo E, Herrera-Marschitz M, Israel Y. Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking. Addiction Biology. 2018. Doi: 10.1111/adb.12675
- Ezquer, F.; De Gregorio, C.; Contador, D.; Santapau, D.; Campero, M.; Ezquer, M. Characterisation of an animal model of type 2 diabetes with potential application in the evaluation of new therapies for diabetic neuropathy. DIABETOLOGIA. 2018.
- De Gregorio, Cristian; Contador, David; Campero, Mario; Ezquer, Marcelo; Ezquer, Fernando. Characterization of diabetic neuropathy progression in a mouse model of type 2 diabetes mellitus. BIOLOGY OPEN. 2018. Doi: 10.1242/bio.036830
- Giraud-Billoud M., Fader C.M., Agüero R., Ezquer F., Ezquer M., Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship. Biocell. 2018.
- Fernando Ezquer, Paola Morales, María Elena Quintanilla, Daniela Santapau, Carolyne Lespay-Rebolledo, Marcelo Ezquer, Mario Herrera-Marschitz & Yedy Israel. Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes bingedrinking. Scientific Reports (2018) 8:4325 | DOI:10.1038/s41598-018-22750-7
- Cuenca, Jimena; Le-Gatt, Alice; Castillo, Valentina; Belletti, Jose; Diaz, Macarena; Monica Kurte, G.; Gonzalez, Paz L.; Alcayaga-Miranda, Francisca; Schuh, Christina M. A. P.; Ezquer, Fernando; Ezquer, Marcelo; Khoury, Maroun. The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration. FRONTIERS IN PHYSIOLOGY. 2018. Doi: 10.3389/fphys.2018.00464
- Ezquer, F.; Quintanilla, M. E.; Morales, P.; Lespay-Rebolledo, C.; Santapau, D.; Ezquer, M.; Herrera-Marschitz, M.; Israel, Y. ANTI-INFLAMMATORY MESENCHYMAL STEM CELLS AND N-ACETYL CYSTEINE INHIBIT CHRONIC ETHANOL INTAKE AND ABOLISH RELAPSE BINGE DRINKING: PRECLINICAL STUDIES. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 2018.
- Ezquer F., Quintanilla M.E., Morales P., Ezquer M., Lespay-Rebolledo C., Herrera-Marschitz M., Israel Y., Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats. Addiction Biology. 2017. Doi: 10.1111/adb.12572
- Giraud-Billoud M., Ezquer F., Bahamonde J., Ezquer M., Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus. Biocell 2017, 41(1): 1-12
- Fernando E. Ezquer, Marcelo E. Ezquer, Jose M. Vicencio & Sebastián D. Calligaris, Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: increasing transplanted cell resistance and increasing tissue receptivity, Cell Adhesion & Migration, Jun 2017, DOI10.1080/19336918.2016.1197480
- Israel, Yedy; Elena Quintanilla, Maria; Morales, Paola; Ezquer, Marcelo; Herrera-Marschitz, Mario; Ezquer, Fernando, Alcohol intake: from initiation to maintenance and relapse binge-drinking. Mechanisms and translational opportunities, Alcohol And Alcoholism, Oct 2017
- Morales, P.; Ezquer, F.; Quintanilla, M. E.; Lespay-Rebolledo, C.; Santapau, D.; Valdes, J. L.; Kogan, M.; Salas, E.; Herrera-Marschitz, M.; Israel, Y. Anti-Inflammatory Mesenchymal Stem Cell-Derived Spheroids Inhibit Chronic And Relapse-Like Ethanol Intake And Reduce Oxidative Stress, Alcohol And Alcoholism, Oct 2017, DOI10.1093/alcalc/agx074.05
- Maximiliano Giraud-Billoud M, Ezquer F, Bahamonde J, Ezquer M. Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus. Biological Research. 2016.
- Losinno A.D., Sorrivas V., Ezquer M., Ezquer F., López L.A., Morales A. Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule. Cell and Tussue Research .2016 Ago: 425-435. Doi: 10.1007/s00441-016-2386-x
- Ezquer F., Bruna F., Calligaris S., Conget P., Ezquer M. Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease. World Journal of Gastroenterology. 2016 Ene: 24-36. Doi: 10.3748/wjg.v22.i1.24
- Ezquer M., Urzua C.A., Montecino S., Leal K., Conget P., Ezquer F. Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice. Stem Cell Res Ther. 2016. Doi 10.1186/s13287-016-0299-y
- Fernando E. Ezquer, Marcelo E. Ezquer, Jose M. Vicencio & Sebastián D. Calligaris. Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: increasing transplanted cell resistance and increasing tissue receptivity. Cell Adhesion & Migration. 2016. Doi 10.1080/19336918.2016.1197480
- Abrigo J., Rivera J.C., Aravena J., Cabrera D., Simon F., Ezquer F., Ezquer M., Cabello-Verrugio C. High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis. Cell Adhesion & Migration. 2016. doi: 10.1080/19336918.2016.1197480
- Israel Y, Ezquer F, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz M. Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats. Alcohol and Alcoholism. 2016. Doi: 10.1093/alcalc/agw068
- Ezquer F, Gatica M, Arredondo V, Giraud-Billoud M, Conget P, Ezquer M. Mesenchymal Stem cells prevented the progression of diabetic nephropathy, improved renal function and microvascular architecture in a chronic model of type 1 diabetes mellitus. Cytotherapy. 2015 Jun;17(6):S66-S.
- Montecino S, Leal K, Urzua C, Ezquer M, Conget P, Ezquer F. Intravitreal administration of multipotent mesenchymal stromal cells increases neurotrophic factors levels, reduces oxidative damage and prevents retinal neuronal cell loss in diabetic mice. Cytotherapy. 2015 Jun;17(6):S66-S7
- Could cancer and infection be adverse effects of mesenchymal stromal cell therapy? Arango-Rodriguez ML, Ezquer F, Ezquer M, Conget P. World J Stem Cells. 2015 Mar 26;7(2):408-417. Review. PMID:25815124
- Ezquer F, Gutiérrez J, Ezquer M, Caglevic C, Salgado HC, Calligaris SD. Mesenchymal stem cell therapy fordoxorubicin cardiomyopathy: hopes and fears. Stem Cell Res Ther. 2015; 6:116.
- Contador D, Ezquer F, Espinosa M, Arango-Rodriguez M, Puebla C, Sobrevia L, Conget P. Dexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells. Exp Biol Med (Maywood). 2015 Jan 16. pii:1535370214566565. [Epub ahead of print] PMID:25595190[PubMed – as supplied by publisher]
- Ezquer F, Giraud-Billoud M, Carpio D, Cabezas F, Conget P, Ezquer M. Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus. Biomed Res Int. 2015. DOI: 10.1155/2015/164703
- Campero M, Ezquer M, Ezquer F. Nerve Excitability and Structural Changes in Myelinated Axons from Diabetic Mice. Exp Clin Endocrinol Diabetes. 2015 Aug 18. [Epub ahead of print] PMID:26285066