Cargo actual
- Director Centro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana Universidad del Desarrollo.
- Docente e investigador, Facultad de Medicina Clínica Alemana Universidad del Desarrollo.
- Miembro del Comité de Doctorado de Ciencias Médicas, Facultad de Medicina Clínica Alemana Universidad del Desarrollo.
Docencia
- Organizador y docente del curso “Medicina Regenerativa y células madre”, del programa de Postgrado en Biología de la Facultad de Medicina de la Universidad Nacional de Cuyo, Argentina. a partir de 2013.
- Tutor Unidad de Investigación, Doctorado en Ciencias Médicas, Facultad de Medicina CAS-UDD.
- Docente Unidad de Investigación, segundo año de Medicina, Facultad de Medicina CAS-UDD.
- Tutor de tesis de pregrado, doctorado y postdoctorado.
- Integrante Comités Tutoriales en el programa de Postgrado de la Facultad de Medicina de la Universidad Nacional de Cuyo (PROBIOL).
Proyectos de investigación
- Acute on chronic liver failure: reversion by systemic administration of 3D spheroids-derived mesenchymal stem cells. Fondecyt Regular 2020.
- International Research Network for the development of induced pluripotent stem cell technology/ cod. 150065 (2016-2018). REDES.
- Evaluation of the therapeutic effect of mesenchymal stem cell -acelular derivate- on drug induced steatosis, in a model of normal and impaired liver regeneration capacity (2015-2018) Folio N° 1150589, FONDECYT Regular.
- Fondef IdeA Ciencia Aplicada CA130088 “Producto derivado de células troncales mesenquimaticas favorece la regeneración del hígado en individuos con esteatosis sometidos a cirugía de resección hepática” (2014-2015).
- Fondecyt Regular trianual (N°1120133) “The etiology of diabetes and/or the stage of diabetic nephropathy modify the renoprotective effect of donor multipotent mesenchymal stromal cells?” 2012-2015.
- “Characterization of the mechanisms associated to therapeutic effects observed after Mesenchymal Stem Cells administration into mice with the hepatic manifestation of metabolic syndrome” (2009-2011). Fondecyt de Iniciación trianual (N°11085034).
- Proyecto Cerveza y Salud. Co-Investigador. ACECHI (2009-2011).
- “La administración endovenosa de células troncales mesenquimáticas corrige la nefropatía diabética en modelo murino de diabetes mellitus tipo 2”. Concurso regular CAS-UDD 2009-2010.
- Medicina Regenerativa para diabetes y sus complicaciones. Co-Investigador. Programa Bicentenario de Ciencia y Tecnología (2006-2009).
Últimas publicaciones
- Rosenberger, L., Ezquer, M., Lillo-Vera, F., Pedraza, P. L., Ortuzar, M. I., Gonzalez, P. L., Figueroa-Valdes, A. I., Cuenca, J., Ezquer, F., Khoury, M., Alcayaga-Miranda, F. Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma, SCIENTIFIC REPORTS, Ene 2019, DOI: 10.1038/s41598-018-36855-6
- Elena Quintanilla, Maria; Morales, Paola; Ezquer, Fernando; Ezquer, Marcelo; Herrera-Marschitz, Mario; Israel, Yedy. Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 2018. Doi: 10.1111/acer.13842
- Ezquer F, Quintanilla ME, Morales P, Santapau D, Ezquer M, Kogan MJ, Salas-Huenuleo E, Herrera-Marschitz M, Israel Y. Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking. Addiction Biology. 2018. Doi: 10.1111/adb.12675
- Ezquer, F.; De Gregorio, C.; Contador, D.; Santapau, D.; Campero, M.; Ezquer, M. Characterisation of an animal model of type 2 diabetes with potential application in the evaluation of new therapies for diabetic neuropathy. DIABETOLOGIA. 2018.
- Giraud-Billoud M., Fader C.M., Agüero R., Ezquer F., Ezquer M., Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship. Biocell. 2018.
- Fernando Ezquer, Paola Morales, María Elena Quintanilla, Daniela Santapau, Carolyne Lespay-Rebolledo, Marcelo Ezquer, Mario Herrera-Marschitz & Yedy Israel. Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes bingedrinking. Scientific Reports (2018) 8:4325 | DOI:10.1038/s41598-018-22750-7
- Cuenca, Jimena; Le-Gatt, Alice; Castillo, Valentina; Belletti, Jose; Diaz, Macarena; Monica Kurte, G.; Gonzalez, Paz L.; Alcayaga-Miranda, Francisca; Schuh, Christina M. A. P.; Ezquer, Fernando; Ezquer, Marcelo; Khoury, Maroun. The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration. FRONTIERS IN PHYSIOLOGY. 2018. Doi: 10.3389/fphys.2018.00464
- Ezquer, F.; Quintanilla, M. E.; Morales, P.; Lespay-Rebolledo, C.; Santapau, D.; Ezquer, M.; Herrera-Marschitz, M.; Israel, Y. ANTI-INFLAMMATORY MESENCHYMAL STEM CELLS AND N-ACETYL CYSTEINE INHIBIT CHRONIC ETHANOL INTAKE AND ABOLISH RELAPSE BINGE DRINKING: PRECLINICAL STUDIES. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 2018.
- Ezquer F., Quintanilla M.E., Morales P., Ezquer M., Lespay-Rebolledo C., Herrera-Marschitz M., Israel Y., Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats. Addiction Biology. 2017. Doi: 10.1111/adb.12572
- Giraud-Billoud M., Ezquer F., Bahamonde J., Ezquer M., Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus. Biocell 2017, 41(1): 1-12
- Fernando E. Ezquer, Marcelo E. Ezquer, Jose M. Vicencio & Sebastián D. Calligaris, Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: increasing transplanted cell resistance and increasing tissue receptivity, Cell Adhesion & Migration, Jun 2017, DOI10.1080/19336918.2016.1197480
- Israel, Yedy; Elena Quintanilla, Maria; Morales, Paola; Ezquer, Marcelo; Herrera-Marschitz, Mario; Ezquer, Fernando, Alcohol intake: from initiation to maintenance and relapse binge-drinking. Mechanisms and translational opportunities, Alcohol And Alcoholism, Oct 2017
- Morales, P.; Ezquer, F.; Quintanilla, M. E.; Lespay-Rebolledo, C.; Santapau, D.; Valdes, J. L.; Kogan, M.; Salas, E.; Herrera-Marschitz, M.; Israel, Y. Anti-Inflammatory Mesenchymal Stem Cell-Derived Spheroids Inhibit Chronic And Relapse-Like Ethanol Intake And Reduce Oxidative Stress, Alcohol And Alcoholism, Oct 2017, DOI10.1093/alcalc/agx074.05
- Maximiliano Giraud-Billoud M, Ezquer F, Bahamonde J, Ezquer M. Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus. Biological Research. 2016.
- Losinno A.D., Sorrivas V., Ezquer M., Ezquer F., López L.A., Morales A. Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule. Cell and Tussue Research .2016 Ago: 425-435.
- Losinno A.D., Sorrivas V., Ezquer M., Ezquer F., López L.A., Morales A. Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule. Cell and Tussue Research .2016 Ago: 425-435.
- Ezquer F., Bruna F., Calligaris S., Conget P., Ezquer M. Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease. World Journal of Gastroenterology. 2016 Ene: 24-36.
- Ezquer M., Urzua C.A., Montecino S., Leal K., Conget P., Ezquer F. Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice. Stem Cell Res Ther. 2016.
- Fernando E. Ezquer, Marcelo E. Ezquer, Jose M. Vicencio & Sebastián D. Calligaris. Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: increasing transplanted cell resistance and increasing tissue receptivity. Cell Adhesion & Migration. 2016.
- Abrigo J., Rivera J.C., Aravena J., Cabrera D., Simon F., Ezquer F., Ezquer M., Cabello-Verrugio C. High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis. Cell Adhesion & Migration. 2016.
- Israel Y, Ezquer F, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz M. Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats. Alcohol and Alcoholism. 2016.
- Ezquer F, Gatica M, Arredondo V, Giraud-Billoud M, Conget P, Ezquer M. Mesenchymal Stem cells prevented the progression of diabetic nephropathy, improved renal function and microvascular architecture in a chronic model of type 1 diabetes mellitus. Cytotherapy. 2015 Jun;17(6):S66-S.
- Montecino S, Leal K, Urzua C, Ezquer M, Conget P, Ezquer F. Intravitreal administration of multipotent mesenchymal stromal cells increases neurotrophic factors levels, reduces oxidative damage and prevents retinal neuronal cell loss in diabetic mice. Cytotherapy. 2015 Jun;17(6):S66-S7
- Could cancer and infection be adverse effects of mesenchymal stromal cell therapy? Arango-Rodriguez ML, Ezquer F, Ezquer M, Conget P. World J Stem Cells. 2015 Mar 26;7(2):408-417. Review. PMID:25815124
- Ezquer F, Gutiérrez J, Ezquer M, Caglevic C, Salgado HC, Calligaris SD. Mesenchymal stem cell therapy fordoxorubicin cardiomyopathy: hopes and fears. Stem Cell Res Ther. 2015; 6:116.
- Ezquer F, Giraud-Billoud M, Carpio D, Cabezas F, Conget P, Ezquer M. Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus. Biomed Res Int. 2015. DOI: 10.1155/2015/164703
- Campero M, Ezquer M, Ezquer F. Nerve Excitability and Structural Changes in Myelinated Axons from Diabetic Mice. Exp Clin Endocrinol Diabetes. 2015 Aug 18. [Epub ahead of print] PMID:26285066