Mauricio Retamal

Mauricio  Retamal

Mauricio Retamal

Tema principal: biofísica y biología molecular de canales formados por conexinas; Hemicanales y canales de uniones en hendidura.

  • Licenciado Ciencias, mención Biología, Universidad de Chile, 2000.
  • Doctor en Ciencias (PhD), mención Fisiología, P. Universidad Católica Chile, 2005.
  • Becario de investigación, Albert Eistein Coll Med, New York, USA, 7 meses 2004.
  • Adiestramiento postdoctoral investigac ión, Lab Neuropharmacologie, Collège de France, Paris, Francia, 3 meses 2006.
  • Adiestramiento postdoctoral investigación, Dept Cell Physiology & Mol Biophysics, Texas Techn Univ, 12 meses 2007.
  • Investigador Asociado, Dept Cell Physiology & Mol Biophysics, Texas Techn Univ, USA, 2 meses 2008.
  • Docente Fisiología, Facultad de Medicina CAS-UDD, Chile, 2008 →.
  • Proyecto FONDECYT iniciación, 2007.
  • Proyecto FONDECYT regular, 2012-2015.
  • Proyecto FONDECYT regular, 2016-2019.
  • Miembro Anillo Investigación CONICYT, 2012-2015.
  • Membresía sociedades científicas: Soc. Chilena Cs. Fisiológicas; Soc. Neurosci, USA.

 

 

Publicaciones

 

  • 2000 Alcayaga J, Cerpa V, Retamal M, Arroyo J, Iturriaga R, Zapata P. Adenosine triphosphate-induced peripheral nerve discharges generated from the cat petrosal ganglion in vitro. Neurosci Lett. 282(3):185-8.
  • 2003 Alcayaga J, Retamal M, Cerpa V, Arroyo J, Zapata P. Dopamine inhibits ATP-induced responses in the cat petrosal ganglion in vitro. Brain Res. 966(2):283-7.
  • 2003 Sáez JC, Contreras JE, Bukauskas FF, Retamal MA, Bennett MV. Gap junction hemichannels in astrocytes of the CNS. Acta Physiol Scand. 2003 Sep;179(1):9-22.
  • 2005 Sáez JC, Retamal MA, Basilio D, Bukauskas FF, Bennett MV. Connexin-based gap junction hemichannels: gating mechanisms. Biochim Biophys Acta. 2005 Jun 10;1711(2):215-24.
  • 2006 Retamal MA, Cortés CJ, Reuss L, Bennett MV, Sáez JC. S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4475-80
  • 2007 Retamal MA, Schalper KA, Shoji KF, Bennett MV, Sáez JC. Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8322-7.
  • 2007 Retamal MA, Schalper KA, Shoji KF, Orellana JA, Bennett MV, Sáez JC. Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion. J Membr Biol. 2007 Aug;218(1-3):49-63.
  • 2007 Retamal MA, Froger N, Palacios-Prado N, Ezan P, Sáez PJ, Sáez JC, Giaume C. Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. J Neurosci. 2007 Dec 12;27(50):13781-92.
  • 2008 Schalper KA, Palacios-Prado N, Retamal MA, Shoji KF, Martínez AD, Sáez JC. Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses. Mol Biol Cell. 2008 Aug;19(8):3501-13. doi: 10.1091/mbc.E07-12-1240.
  • 2009 Retamal MA, Yin S, Altenberg GA, Reuss L. Modulation of Cx46 hemichannels by nitric oxide. Am J Physiol Cell Physiol 296: C1356-1363.
  • 2010 Retamal MA, Yin S, Altenberg GA, Reuss L. Voltage-dependent facilitation of Cx46 hemichannels. Am J Physiol Cell Physiol 298: C132-139
  • 2010 Ponsaerts R, De Vuyst E, Retamal M, D’hondt C, Vermeire D, Wang N, De Smedt H, Zimmermann P, Himpens B, Vereecke J, Leybaert L, Bultynck G. Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity. FASEB J 24: 4378-4395.
  • 2010 Sáez JC, Schalper KA, Retamal MA, Orellana JA, Shoji KF, Bennett MV. Cell membrane permeabilization via connexin hemichannels in living and dying cells. Exp Cell Res 316: 2377-2389.
  • 2011 Retamal MA, Evangelista-Martínez F, León-Paravic CG, Altenberg GA, Reuss L. Biphasic effect of linoleic acid on connexin 46 hemichannels. Pflügers Arch – Eur J Physiol 461: 635–643.
  • 2011 Retamal MA, León-Paravic CG, Verdugo CA, Alcaíno CA, Moraga-Amaro R, Stehberg J. Connexin in lens physiology and cataract formation. J Clin Exp Ophthalmol, sp issue 1, 13 pp, available online. doi:10.4172/2155-9570.S1-001
  • 2012 Vielma AH, Retamal MA, Schmachtenberg O. Nitric oxide signaling in the retina: What have we learned in two decades? Brain Res 1430: 112-125
  • 2012 Stehberg J, Moraga-Amaro R, Salazar C, Becerra A, Echeverría C, Orellana JA, Bultynck G, Ponsaerts R, Leybaert L, Simon F, Sáez JC, Retamal MA. Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J 26: 3649-3657
  • 2013 Figueroa V, Sáez PJ, Salas JD, Salas D, Jara O, Martínez AD, Sáez JC, Retamal MA. Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca2+-dependent pathway. Biochem Biophys Acta 1828: 1169–1179
  • 2013 Sáez PJ, Shoji KF, Retamal MA, Harcha PA, Ramírez G, Jiang JX, von Bernhardi R, Saez JC. ATP is required and advances cytokine-induced gap junction formation in microglia in vitro. Mediators Inflamm 2013: 216402. 16 pages. doi: 10.1155/2013/216402
  • 2013 Iyyathurai J, D’hondt C, Wang N, De Bock M, Himpens B, Retamal MA, Stehberg J, Leybaert L, Bultynck G. Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: gap junctions versus hemichannels. Neuropharmacology 75: 491-505
  • 2013 Orellana JA, Martinez AD, Retamal MA. Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules. Neuropharmacology 75: 567-582
  • 2013 Giaume C, Froger N, Orellana JA, Retamal MA, Sáez JC. Impact of microglial activation on astroglial connexin expression and function in brain inflammation. Chapter 11 in: E Oviedo-Orta, BR Kwak, WH Evans, eds: “Connexin Cell Communication Channels. Roles in the Immune System and Immunopathology”, pp 219-232. CRC Press: Taylor and Francis group. ISBN: 978-1-4398-6257-5
  • 2014 Retamal MA. Connexin and pannexin hemichannels are regulated by redox potentials. Front Physiol 5: 80
  • 2014 Reyes EP, Cerpa V, Corvalán L, Retamal MA. Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals. Front Cell Neurosci 8: 123
  • 2014 Retamal MA, Alcayaga J, Bultynck G, Leybaert L, Sáez PJ, Fernández , León LE, Sáez JC. Opening of pannexin and connexin based-channels increases the excitability of nodose ganglion sensory neurons. Front Cell Neurosci 8: 158
  • 2014 Figueroa VA, Retamal MA, Cea LA, Salas JD, Vargas AA, Verdugo CA, Jara O, Martinez AD, Sáez JC. Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells. Front Cell Neurosci 8: 265
  • 2014 Retamal MA, Sáez JC. Hemichannels; from the molecule to the function. Front Physiol 5: 411.
  • 2014 León-Paravic CG, Figueroa V, Guzmán DJ, Valderrama CF, Vallejos AA, Fiori MC, Altenberg GA, Reuss L, Retamal MA. Carbon Monoxide (CO) a novel inhibitor of connexin hemichannels. J Biol Chem 289: 36150-36157
  • 2014 Retamal MA, Reyes EP, Alcayaga J. Petrosal ganglion: a more complex role than originally imagined. Front Physiol 5: 474
  • 2015 Fiori MC, Krishnan S, Cortes DM, Retamal MA, Reuss L, Altenberg GA, Cuello LG. Functional hemichannels formed by human connexin 26 expressed in bacteria”. Biosci Reports 18: 35(2)
  • 2015 Retamal MA, León-Paravic CG, Ezquer M, Ezquer F, Del Rio R, Pupo A, Martínez AD, González C. Carbon monoxide: A new player in the redox regulation of connexin hemichannels. IUBMB Life 67(6): 428-437
  • 2015 Retamal MA, Reyes EP, García IE, Pinto B, Martínez AD, González C. Diseases associated with leaky hemichannels. Front Cell Neurosci 9: 267
  • 2015 Del Rio R, Quintanilla RA, Orellana JA, Retamal MA. Neuron-glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis. Front Physiol 6: 350. doi: 10.3389/fphys.2015.00350
  • 2016 Dalamon V, Fiori MC, Figueroa VA, Oliva CA, del Río R, González W, Canan J, Elgoyhen AB, Altenberg GA, Retamal MA. Gap-junctional channel and hemichannel activity in two recently identified connexin 26 mutants associated with deafness. Pflügers Arch 468 (5): 909-918
  • 2016 Retamal MA, García IE, Pinto B, Pupo A, Baez-Nieto D, Stehberg J, Del Rio R, Gonzalez C. Extracellular cysteine in connexins: role as redox sensors. Front Physiol 7: 1
  • 2016 García IE., Prado P, Pupo A, Jara O, Rojas-Gómez D, Mujica P, Flores-Muñoz C, González-Casanova J, Soto-Riveros C, Retamal MA, González C, Martínez AD. Connexinopathies: a structural and functional glimpse. BMC Cell Biol 17 (suppl 1): 17.
  • 2016 Pogoda K, Kameritsch P, Retamal MA, Vega JL. Regulation of gap junction channels and hemichannels by phosphorylation and redox changes, a revision. BMC Cell Biol 17 (suppl 1): 11
  • 2016 Pinto BI, Garcia IE., Pupo A, Retamal MA, Martinez AD., Latorre R, Gonzalez C. Charged residues at the first transmembrane region contribute to the voltage dependence of the slow gate of connexins. J Biol Chem 291 (30): 15740-15752
  • 2016 Orellana JA, Retamal MA, Moraga-Amaro R, Stehberg J. Role of astroglial hemichannels and pannexons in memory and neurodegenerative diseases. Front Integr Neurosci 10:26
  • 2016 Calderón JF, Retamal MA. Regulation of connexins expression levels by microRNAs, an update. Front Physiol 7: 558.
  • 2016 Retamal MA. Carbon monoxide modulates connexin function through a lipid peroxidation-dependent process: A hypothesis. Front Physiol 7: 259
  • 2016 Retamal MA, Bennett MV, Pelegrin P, Fernandez R. Ion channels in inflammatory processes: What is known and what is next? Mediators Inflamm 2016: 6245731
  • 2017 Toledo C, Andrade DC, Lucero C, Schultz HD, Marcus NJ, Retamal MA, Madrid C, Del Rio R. Contribution of peripheral and central chemoreceptors to sympatho-excitation in heart failure. J Physiol 595 (1): 43-51
  • 2017 Puebla C, Retamal MA, Acuña R, Sáez JC. Regulation of connexin-based channels by fatty acids. Front Physiol 8: 11
  • 2017 García IE, Sánchez HA, Martínez AD, Retamal MA. Redox-mediated regulation of connexin proteins; focus on nitric oxide. Biochim Biophys Acta. 2017 Oct 7. pii: S0005-2736(17)30316-4. doi: 10.1016/j.bbamem.2017.10.006.