Figueroa, Vania A.; Jara, Oscar; Oliva, Carolina A.; Ezquer, Marcelo; Ezquer, Fernando; Retamal, Mauricio A.; Martinez, Agustin D.; Altenberg, Guillermo A.; Vargas, Anibal A., Contribution of connexin hemichannels to the decreases in cell viability induced by linoleic acid in the human lens epithelial cells (HLE-B3), Frontiers in Physiology 2020, DOI: 10.3389/fphys.2019.01574
Acuna, Rodrigo A.; Varas-Godoy, Manuel; Berthoud, Viviana M.; Alfaro, Ivan E.; Retamal, Mauricio A., Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells, BIOMOLECULES 2020, DOI: 10.3390/biom10050676
Belen Bachli, M.; Sedeno, Lucas; Ochab, Jeremi K.; Piguet, Olivier; Kumfor, Fiona; Reyes, Pablo; Torralva, Teresa; Roca, Maria; Felipe Cardona, Juan; Gonzalez Campo, Cecilia; Herrera, Eduar; Slachevsky, Andrea; Matallana, Diana; Manes, Facundo; Garcia, Adolfo M.; Ibanez, Agustin; Chialvo, Dante R., Evaluating the reliability of neurocognitive biomarkers of neurodegenerative
diseases across countries: A machine learning approach, NEUROIMAGE 2020, DOI: 10.1016/j.neuroimage.2019.116456
Cortes Fuentes, Ignacio A.; Burotto, Mauricio; Retamal, Mauricio A.; Frelinghuysen, Michael; Caglevic, Christian; Gormaz, Juan G., Potential use of n-3 PUFAs to prevent oxidative stress-derived ototoxicity caused by platinum-based chemotherapy, Free Radical Biology and Medicine 2020, DOI: 10.1016/j.freeradbiomed.2020.07.035
Eugenin, Jaime; Larrain, Carolina; Zapata, Patricio, Plasticity of cardiovascular chemoreflexes after prolonged unilateral carotid body denervation: implications for its therapeutic use, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2020, DOI: 10.1152/ajpheart.00451.2019
Lucero, Claudia M.; Andrade, David C.; Toledo, Camilo; Diaz, Hugo S.; Pereyra, Katherin V.; Diaz-Jara, Esteban; Schwarz, Karla G.; Marcus, Noah J.; Retamal, Mauricio A.; Quintanilla, Rodrigo A.; Del Rio, Rodrigo, Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats, Scientific Reports 2020, DOI: 10.1038/s41598-020-63336-6
Orellana, Viviana P.; Tittarelli, Andres; Retamal, Mauricio A., Connexins in melanoma: Potential role of Cx46 in its aggressiveness, PIGMENT CELL & MELANOMA RESEARCH 2020, DOI: 10.1111/pcmr.12945
Retamal, MA; Fiori, MC; Fernandez-Olivares, A; Linsambarth, S; Pena, F; Quintana, D; Stehberg, J; Altenberg, GA, 4-Hydroxynonenal induces Cx46 hemichannel inhibition through its carbonylation, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2020, DOI: 10.1016/j.bbalip.2020.158705
Rozas-Villanueva, Maria F.; Casanello, Paola; Retamal, Mauricio A., Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece?, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020, DOI: 10.3390/ijms21134698
Saez, Juan C.; Contreras-Duarte, Susana; Labra, Valeria C.; Santibanez, Cristian A.; Mellado, Luis A.; Inostroza, Carla A.; Alvear, Tanhia F.; Retamal, Mauricio A.; Velarde, Victoria; Orellana, Juan A., Interferon-gamma and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2020, DOI: 10.1016/j.bbamcr.2020.118720
García IE., Prado P, Pupo A, Jara O, Rojas-Gómez D, Mujica P, Flores-Muñoz C, González-Casanova J, Soto-Riveros C, Retamal MA, González C, Martínez AD. Connexinopathies: a structural and functional glimpse. BMC Cell Biol 17 (suppl 1): 17.
Pogoda K, Kameritsch P, Retamal MA, Vega JL. Regulation of gap junction channels and hemichannels by phosphorylation and redox changes, a revision. BMC Cell Biol 17 (suppl 1): 11.
Pinto BI, Garcia IE., Pupo A, Retamal MA, Martinez AD., Latorre R, Gonzalez C. Charged residues at the first transmembrane region contribute to the voltage dependence of thye slow gate of connexins. J Biol Chem 291 (30): 15740-15752
Retamal MA. Carbon monoxide modulates connexin function through a lipid peroxidation-dependent process: A hypothesis. Front Physiol 7: 259
Retamal MA, Bennett MV, Pelegrin P, Fernandez R. Ion channels in inflammatory processes: What is known and what is next? Mediators Inflamm 2016: 6245731
Cerpa V, Wu Y, Bravo E, Teran FA, Flynn RS, Richerson GB. Medullary 5-HT neurons: Switch from tonic respiratory drive to chemoreception during postnatal development. Neuroscience pii: S0306-4522(16)30440-7.
Reyes EP, Cortes PP, Fernandez R. Animal models for sepsis research. SMGroup eBooks, 9 pp. www.smgebooks.com/sepsis/chapters/SEP-16-01.pdf
Gysling K, Corvalán L, Fuentealba JA. “El Cerebro Adicto. Por qué abusamos de las drogas, el alcohol, la nicotina y muchas cosas más.”. Ediciones UC, Santiago, Chile, 247 págs. Traducción al castellano del libro “The Addicted Brain. Why We Abuse Drugs, Alcohol, and Nicotine”, by Michael Kuhar, 2011.
Retamal MA, García IE, Pinto B, Pupo A, Baez-Nieto D, Stehberg J, Del Rio R, Gonzalez C. Extracellular cysteine in connexins: role as redox sensors. Front Physiol 7: 1. In press
Nardocci G, Martin A, Abarzúa S, Rodríguez J, Simón F, Reyes EP, Acuña-Castillo C, Navarro C, Cortés PP, Fernández R. Sepsis progression to multiple organ dysfunction in carotid chemo/barodenervated rats treated with lipopolysaccharide. J Neuroimmunol 278: 44-52
Fernández R, Cortés P, Del Rio R, Acuña-Castillo C, Reyes EP. Lipopolysaccharide-induced ionized hypocalcemia and acute kidney injury in carotid chemo/baro-denervated rats. Adv Exp Med Biol 860: 161-166
Fiori MC, Krishnan S, Cortes DM, Retamal MA, Reuss L, Altenberg GA, Cuello LG. Functional hemichannels formed by human connexin 26 expressed in bacteria». Biosci Reports 18: 35(2)
Retamal MA, León-Paravic CG, Ezquer M, Ezquer F, Del Rio R, Pupo A, Martínez AD, González C. Carbon monoxide: A new player in the redox regulation of connexin hemichannels. IUBMB Life 67(6): 428-437
Retamal MA, Reyes EP, García IE, Pinto B, Martínez AD, González C. Diseases associated with leaky hemichannels. Front Cell Neurosci 9: 267
Del Rio R, Quintanilla RA, Orellana JA, Retamal MA. Neuron-glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis. Front Physiol 6: 350. doi: 10.3389/fphys.2015.00350
Cerpa VJ, Aylwin M de L, Beltrán-Castillo S, Bravo EU, Llona IR, Richerson GB, Eugenín JL. The alteration of neonatal raphe neurons by prenatal-perinatal nicotine. Meaning for Sudden Infant Death Syndrome. Am J Respir Cell Mol Biol 53 (4): 489-499
Andrade DC, Lucero C, Toledo C, Madrid C, Marcus NJ, Schultz HD, Del Rio R. Relevance of the carotid body chemoreflex in the progression of heart failure. Review. Biomed Res Intl, E-pub Dec 8.
2014
Retamal MA. Connexin and pannexin hemichannels are regulated by redox potentials. Front Physiol 5: 80
Reyes EP, Cerpa V, Corvalán L, Retamal MA. Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals. Front Cell Neurosci 8: 123
Retamal MA, Alcayaga J, Bultynck G, Leybaert L, Sáez PJ, Fernández , León LE, Sáez JC. Opening of pannexin and connexin based-channels increases the excitability of nodose ganglion sensory neurons. Front Cell Neurosci 8: 158
Figueroa VA, Retamal MA, Cea LA, Salas JD, Vargas AA, Verdugo CA, Jara O, Martinez AD, Sáez JC. Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells. Front Cell Neurosci 8: 265
Retamal MA, Sáez JC. Hemichannels; from the molecule to the function. Front Physiol 5: 411.
Retamal MA, Reyes EP, Alcayaga J. Petrosal ganglion: a more complex role than originally imagined. Front Physiol 5: 474
Fernández R, Nardocci G, Navarro C, Reyes EP, Acuña-Castillo C, Cortés PP. Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy. Front Physiol 5: 489
2013
Figueroa V, Sáez PJ, Salas JD, Salas D, Jara O, Martínez AD, Sáez JC, Retamal MA. Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca2+-dependent pathway. Biochem Biophys Acta 1828: 1169–1179
Sáez PJ, Shoji KF, Retamal MA, Harcha PA, Ramírez G, Jiang JX, von Bernhardi R, Saez JC. ATP is required and advances cytokine-induced gap junction formation in microglia in vitro. Mediators Inflamm 2013: 216402. 16 pages. doi: 10.1155/2013/216402
Iyyathurai J, D’hondt C, Wang N, De Bock M, Himpens B, Retamal MA, Stehberg J, Leybaert L, Bultynck G. Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: gap junctions versus hemichannels. Neuropharmacology 75: 491-505
Orellana JA, Martinez AD, Retamal MA. Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules. Neuropharmacology 75: 567-582
Giaume C, Froger N, Orellana JA, Retamal MA, Sáez JC. Impact of microglial activation on astroglial connexin expression and function in brain inflammation. Chapter 11 in: E Oviedo-Orta, BR Kwak, WH Evans, eds: «Connexin Cell Communication Channels. Roles in the Immune System and Immunopathology«, pp 219-232. CRC Press: Taylor and Francis group. ISBN: 978-1-4398-6257-5
2012
Vielma AH, Retamal MA, Schmachtenberg O. Nitric oxide signaling in the retina: What have we learned in two decades? Brain Res 1430: 112-125
Stehberg J, Moraga-Amaro R, Salazar C, Becerra A, Echeverría C, Orellana JA, Bultynck G, Ponsaerts R, Leybaert L, Simon F, Sáez JC, Retamal MA. Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J 26: 3649-3657
Zapata P, Larraín C, Reyes EP, Fernández R. Shifting from hypoxia to hyperoxia to assess the peripheral chemosensory drive of ventilation. Adv Exp Med Biol 758: 137-142
Reyes EP, Abarzua M, Martin A, Rodríguez J, Cortés PP, Fernández R. LPS-induced c-Fos activation in NTS neurons and plasmatic cortisol increases in septic rats are suppressed by bilateral carotid chemodenervation. Adv Exp Med Biol 758: 185-190
2011
Retamal MA, Evangelista-Martínez F, León-Paravic CG, Altenberg GA, Reuss L. Biphasic effect of linoleic acid on connexin 46 hemichannels. Pflügers Arch – Eur J Physiol 461: 635–643.
Retamal MA, León-Paravic CG, Verdugo CA, Alcaíno CA, Moraga-Amaro R, Stehberg J. Connexin in lens physiology and cataract formation. J Clin Exp Ophthalmol, sp issue 1, 13 pp, available online. doi:10.4172/2155-9570.S1-001
Brown ST, Reyes EP, Nurse CA. Chronic hypoxia upregulates adenosine 2a receptor expression in chromaffin cells via hypoxia inducible factor-2a: Role in modulating secretion. Biochem Biophys Res Comm 412: 466–472
Zapata P, Larraín C, Reyes P, Fernández R. Immunosensory signaling by carotid body chemoreceptors. Respir Physiol Neurobiol 178: 370-374
2010
Retamal MA, Yin S, Altenberg GA, Reuss L. Voltage-dependent facilitation of Cx46 hemichannels. Am J Physiol Cell Physiol 298: C132-139
Ponsaerts R, De Vuyst E, Retamal M, D’hondt C, Vermeire D, Wang N, De Smedt H, Zimmermann P, Himpens B, Vereecke J, Leybaert L, Bultynck G. Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity. FASEB J 24: 4378-4395.
Sáez JC, Schalper KA, Retamal MA, Orellana JA, Shoji KF, Bennett MV. Cell membrane permeabilization via connexin hemichannels in living and dying cells. Exp Cell Res 316: 2377-2389.
2009
Fitzgerald RS, Eyzaguirre C, Zapata P. Fifty years of progress in carotid body physiology. Adv Exp Med Biol 648: 23-34
Zapata P, Larraín C, Rivera MA, Calderón C. Cardio-vascular responses to hyperoxic withdrawal of arterial chemosensory drive. Adv Exp Med Biol 648: 305-314
Retamal MA, Yin S, Altenberg GA, Reuss L. Modulation of Cx46 hemichannels by nitric oxide. Am J Physiol Cell Physiol 296: C1356-1363.
2008
Fernández R, González S, Rey S, Cortés PP, Maisey KR, Reyes EP, Larraín C, Zapata P. Lipopolysaccharide-induced carotid body inflammation in cats: Functional manifestations, histopathology and involvement of tumour necrosis factor-a. Exp Physiol 93: 892-907
2007
Reyes EP, Fernández R, Larraín C, Zapata P. Effects of combined cholinergic-purinergic block upon cat carotid body chemoreceptors in vitro. Respir Physiol Neurobiol 156: 17-22
Reyes EP, Fernández R, Larraín C, Zapata P. Carotid body chemosensory activity and ventilatory chemoreflexes in cats persist after combined cholinergic–purinergic block. Respir Physiol Neurobiol 156: 23-32
Zapata P. Is ATP a suitable co-transmitter in carotid body arterial chemoreceptors? Respir Physiol Neurobiol 157: 106-115
Eyzaguirre C. Electric synapses in the carotid body-nerve complex. Respir Physiol Neurobiol 157: 116-122
2006
Reyes EP, Alcayaga J, Zapata P. Are there interactions between acetylcholine- and ATP-induced responses at the level of a visceral sensory ganglion? Brain Res 1107: 97-103
2005
Zapata P, Larraín C. How the carotid body works: Different strategies and preparations to solve different problems. Biol Res 38: 315-328
