Publicaciones

2020

• Figueroa, Vania A.; Jara, Oscar; Oliva, Carolina A.; Ezquer, Marcelo; Ezquer, Fernando; Retamal, Mauricio A.; Martinez, Agustin D.; Altenberg, Guillermo A.; Vargas, Anibal A., Contribution of connexin hemichannels to the decreases in cell viability induced by linoleic acid in the human lens epithelial cells (HLE-B3), Frontiers in Physiology 2020, DOI: 10.3389/fphys.2019.01574
• Acuna, Rodrigo A.; Varas-Godoy, Manuel; Berthoud, Viviana M.; Alfaro, Ivan E.; Retamal, Mauricio A., Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells, BIOMOLECULES 2020, DOI: 10.3390/biom10050676
• Belen Bachli, M.; Sedeno, Lucas; Ochab, Jeremi K.; Piguet, Olivier; Kumfor, Fiona; Reyes, Pablo; Torralva, Teresa; Roca, Maria; Felipe Cardona, Juan; Gonzalez Campo, Cecilia; Herrera, Eduar; Slachevsky, Andrea; Matallana, Diana; Manes, Facundo; Garcia, Adolfo M.; Ibanez, Agustin; Chialvo, Dante R., Evaluating the reliability of neurocognitive biomarkers of neurodegenerative
• diseases across countries: A machine learning approach, NEUROIMAGE 2020, DOI: 10.1016/j.neuroimage.2019.116456
• Cortes Fuentes, Ignacio A.; Burotto, Mauricio; Retamal, Mauricio A.; Frelinghuysen, Michael; Caglevic, Christian; Gormaz, Juan G., Potential use of n-3 PUFAs to prevent oxidative stress-derived ototoxicity caused by platinum-based chemotherapy, Free Radical Biology and Medicine 2020, DOI: 10.1016/j.freeradbiomed.2020.07.035
• Eugenin, Jaime; Larrain, Carolina; Zapata, Patricio, Plasticity of cardiovascular chemoreflexes after prolonged unilateral carotid body denervation: implications for its therapeutic use, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2020, DOI: 10.1152/ajpheart.00451.2019
• Lucero, Claudia M.; Andrade, David C.; Toledo, Camilo; Diaz, Hugo S.; Pereyra, Katherin V.; Diaz-Jara, Esteban; Schwarz, Karla G.; Marcus, Noah J.; Retamal, Mauricio A.; Quintanilla, Rodrigo A.; Del Rio, Rodrigo, Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats, Scientific Reports 2020, DOI: 10.1038/s41598-020-63336-6
• Orellana, Viviana P.; Tittarelli, Andres; Retamal, Mauricio A., Connexins in melanoma: Potential role of Cx46 in its aggressiveness, PIGMENT CELL & MELANOMA RESEARCH 2020, DOI: 10.1111/pcmr.12945
• Retamal, MA; Fiori, MC; Fernandez-Olivares, A; Linsambarth, S; Pena, F; Quintana, D; Stehberg, J; Altenberg, GA, 4-Hydroxynonenal induces Cx46 hemichannel inhibition through its carbonylation, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2020, DOI: 10.1016/j.bbalip.2020.158705
• Rozas-Villanueva, Maria F.; Casanello, Paola; Retamal, Mauricio A., Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece?, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020, DOI: 10.3390/ijms21134698
• Saez, Juan C.; Contreras-Duarte, Susana; Labra, Valeria C.; Santibanez, Cristian A.; Mellado, Luis A.; Inostroza, Carla A.; Alvear, Tanhia F.; Retamal, Mauricio A.; Velarde, Victoria; Orellana, Juan A., Interferon-gamma and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2020, DOI: 10.1016/j.bbamcr.2020.118720

2019

• Baraban, M., Retamal, M. A., Ortiz, F. C. Editorial: Physiology of Myelin Forming Cells, From Myelination to Neural Modulators, Frontiers in Cellular Neuroscience. DOI: 10.3389/fncel.2019.00475
• Escudero, C. A., Cabeza, C., Moya-Alvarado, G., Maloney, M. T., Flores, C. M., Wu, C., Court, F. A., Mobley, W. C., Bronfman, F. C. c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. SCIENTIFIC REPORTS, DOI: 10.1038/s41598-019-42420-6
• Retamal, M. A., Orellana, V. P., Arevalo, N. J., Rojas, C. G., Arjona, R. J., Alcaino, C. A., Gonzalez, W., Canan, J. G., Moraga-Amaro, R., Stehberg, J., Reuss, L., Altenberg, G. A. Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, DOI: 10.1016/j.niox.2019.02.007
• Vejar, S., Oyarzún, J. E., Retamal, M. A., Ortiz, F. C., Orellana, J. A. Connexin and pannexin-based channels in oligodendrocytes: implications in brain health and disease. Frontiers in Cellular Neuroscience, DOI: 10.3389/fncel.2019.00003
• Vera, N., Acuna-Gallardo, S., Grunenwald, F., Caceres-Verschae, A., Realini, O., Acuna, R., Lladser, A., Illanes, S. E., Varas-Godoy, M. Small Extracellular Vesicles Released from Ovarian Cancer Spheroids in Response to Cisplatin Promote the Pro-Tumorigenic Activity of Mesenchymal Stem Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, DOI: 10.3390/ijms20204972

2018

• Diaz, Mario; Retamal, Mauricio A. Editorial: Modulation of Ion Channels and Ionic Pumps by Fatty Acids: Implications in Physiology and Pathology. FRONTIERS IN PHYSIOLOGY. Doi: 10.3389/fphys.2018.01625
• Verónica Abudara, Mauricio A. Retamal, Rodrigo del Rio, Juan A. Orellana. Synaptic functions of hemichannels: A double-edged sword. Frontiers in Molecular Neuroscience. Doi: 10.3389/fnmol.2018.00435
• Andrade D.C., Iturriaga R., Toledo C., Lucero C.M., Díaz H.S., Arce-Álvarez A., Retamal M.A., Marcus N.J., Alcayaga J., Del Rio R., Topical Application of Connexin43 Hemichannel Blocker Reduces Carotid Body-Mediated Chemoreflex Drive in Rats. Advances in Experimental Medicine and Biology. Doi: 10.1007/978-3-319-91137-3_7
• Riveros, Maria E.; Retamal, Mauricio A. Are Polyunsaturated Fatty Acids Implicated in Histaminergic Dysregulation in Bipolar Disorder?: AN HYPOTHESIS. FRONTIERS IN PHYSIOLOGY. Doi: 10.3389/fphys.2018.00693
• García I.E., Sánchez H.A., Martínez A.D., Retamal M.A., Redox-mediated regulation of connexin proteins; focus on nitric oxide. Biochimica et Biophysica Acta – Biomembranes. Doi: 10.1016/j.bbamem.2017.10.006

2017

• Retamal M.A., Riquelme M.A., Stehberg J., Alcayaga J., Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity?. Advances in Experimental Medicine and Biology. Doi: 10.3389/fnmol.2017.00374
• Torrealba F., Madrid C., Contreras M., Gómez K., Plasticity in the interoceptive system, Advances in Experimental Medicine and Biology, Oct2017, DOI10.1007/978-3-319-62817-2_4
• García IE, Sánchez HA, Martínez AD, Retamal MA. Redox-mediated regulation of connexin proteins; focus on nitric oxide. Biochim Biophys Acta. 2017 Oct 7. pii: S0005-2736(17)30316-4. doi: 10.1016/j.bbamem.2017.10.006.
• Toledo C, Andrade DC, Lucero C, Schultz HD, Marcus NJ, Retamal MA, Madrid C, Del Rio R. Contribution of peripheral and central chemoreceptors to sympatho-excitation in heart failure. J Physiol 595 (1): 43-51.
• Puebla C, Retamal MA, Acuña R, Sáez JC. Regulation of connexin-based channels by fatty acids. Front Physiol 8: 11.

2016

• Dalamon V, Fiori MC, Figueroa VA, Oliva CA, del Río R, González W, Canan J, Elgoyhen AB, Altenberg GA, Retamal MA. Gap-junctional channel and hemichannel activity in two recently identified connexin 26 mutants associated with deafness. Pflügers Arch 468 (5): 909-918.
• Retamal MA, García IE, Pinto B, Pupo A, Baez-Nieto D, Stehberg J, Del Rio R, Gonzalez C. Extracellular cysteine in connexins: role as redox sensors. Front Physiol 7: 1.
• García IE., Prado P, Pupo A, Jara O, Rojas-Gómez D, Mujica P, Flores-Muñoz C, González-Casanova J, Soto-Riveros C, Retamal MA, González C, Martínez AD. Connexinopathies: a structural and functional glimpse. BMC Cell Biol 17 (suppl 1): 17.
• Pogoda K, Kameritsch P, Retamal MA, Vega JL. Regulation of gap junction channels and hemichannels by phosphorylation and redox changes, a revision. BMC Cell Biol 17 (suppl 1): 11.
• Pinto BI, Garcia IE., Pupo A, Retamal MA, Martinez AD., Latorre R, Gonzalez C. Charged residues at the first transmembrane region contribute to the voltage dependence of thye slow gate of connexins. J Biol Chem 291 (30): 15740-15752
• Orellana JA, Retamal MA, Moraga-Amaro R, Stehberg J. Role of astroglial hemichannels and pannexons in memory and neurodegenerative diseases. Front Integr Neurosci 10:26
• Calderón JF, Retamal MA. Regulation of connexins expression levels by microRNAs, an update. Front Physiol 7: 558.
• Retamal MA. Carbon monoxide modulates connexin function through a lipid peroxidation-dependent process: A hypothesis. Front Physiol 7: 259
• Retamal MA, Bennett MV, Pelegrin P, Fernandez R. Ion channels in inflammatory processes: What is known and what is next? Mediators Inflamm 2016: 6245731
• Casanova JP, Madrid C, Contreras M, Rodríguez M, Vasquez M, Torrealba F. A role for the interoceptive insular cortex in the consolidation of learned fear. Behav Brain Res 296: 70-77
• Valdés JL, Contreras M, Riveros ME, Perdomo G, Torrealba F. The histaminergic tuberomamillary nucleus is involved in appetite for sex, water and amphetamine. Plos One 11 (2): e0148484
• Cerpa V, Wu Y, Bravo E, Teran FA, Flynn RS, Richerson GB. Medullary 5-HT neurons: Switch from tonic respiratory drive to chemoreception during postnatal development. Neuroscience pii: S0306-4522(16)30440-7.
• Reyes EP, Cortes PP, Fernandez R. Animal models for sepsis research. SMGroup eBooks, 9 pp. www.smgebooks.com/sepsis/chapters/SEP-16-01.pdf
• Gysling K, Corvalán L, Fuentealba JA. “El Cerebro Adicto. Por qué abusamos de las drogas, el alcohol, la nicotina y muchas cosas más.”. Ediciones UC, Santiago, Chile, 247 págs. Traducción al castellano del libro “The Addicted Brain. Why We Abuse Drugs, Alcohol, and Nicotine”, by Michael Kuhar, 2011.
• Casanova JP, Madrid C, Contreras M, Rodríguez M, Vasquez M, Torrealba F. A role for the interoceptive insular cortex in the consolidation of learned fear. Behav Brain Res 296: 70-77
• Dalamon V, Fiori MC, Figueroa VA, Oliva CA, del Rio R, Gonzalez W, Canan J, Elgoyhen AB, Altenberg GA, Retamal MA. Gap-junctional channel and hemichannel activity of two recently-identified connexin 26 mutants associated with deafness. Pflügers Arch, online, in press
• Retamal MA, García IE, Pinto B, Pupo A, Baez-Nieto D, Stehberg J, Del Rio R, Gonzalez C. Extracellular cysteine in connexins: role as redox sensors. Front Physiol 7: 1. In press
• Valdes JL, Contreras M, Riveros ME, Perdomo G, Torrealba F. The histaminergic tuberomamillary nucleus is involved in appetite for sex, water and amphetamine. Plos One PONE-D-15-00780R1.

2015

• Nardocci G, Martin A, Abarzúa S, Rodríguez J, Simón F, Reyes EP, Acuña-Castillo C, Navarro C, Cortés PP, Fernández R. Sepsis progression to multiple organ dysfunction in carotid chemo/barodenervated rats treated with lipopolysaccharide. J Neuroimmunol 278: 44-52
• Fernández R, Cortés P, Del Rio R, Acuña-Castillo C, Reyes EP. Lipopolysaccharide-induced ionized hypocalcemia and acute kidney injury in carotid chemo/baro-denervated rats. Adv Exp Med Biol 860: 161-166
• Fiori MC, Krishnan S, Cortes DM, Retamal MA, Reuss L, Altenberg GA, Cuello LG. Functional hemichannels formed by human connexin 26 expressed in bacteria». Biosci Reports 18: 35(2)
• Retamal MA, León-Paravic CG, Ezquer M, Ezquer F, Del Rio R, Pupo A, Martínez AD, González C. Carbon monoxide: A new player in the redox regulation of connexin hemichannels. IUBMB Life 67(6): 428-437
• Retamal MA, Reyes EP, García IE, Pinto B, Martínez AD, González C. Diseases associated with leaky hemichannels. Front Cell Neurosci 9: 267
• Del Rio R, Quintanilla RA, Orellana JA, Retamal MA. Neuron-glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis. Front Physiol 6: 350. doi: 10.3389/fphys.2015.00350
• Cerpa VJ, Aylwin M de L, Beltrán-Castillo S, Bravo EU, Llona IR, Richerson GB, Eugenín JL. The alteration of neonatal raphe neurons by prenatal-perinatal nicotine. Meaning for Sudden Infant Death Syndrome. Am J Respir Cell Mol Biol 53 (4): 489-499
• Andrade DC, Lucero C, Toledo C, Madrid C, Marcus NJ, Schultz HD, Del Rio R. Relevance of the carotid body chemoreflex in the progression of heart failure. Review. Biomed Res Intl, E-pub Dec 8.

2014

• Retamal MA. Connexin and pannexin hemichannels are regulated by redox potentials. Front Physiol 5: 80
• Reyes EP, Cerpa V, Corvalán L, Retamal MA. Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals. Front Cell Neurosci 8: 123
• Retamal MA, Alcayaga J, Bultynck G, Leybaert L, Sáez PJ, Fernández , León LE, Sáez JC. Opening of pannexin and connexin based-channels increases the excitability of nodose ganglion sensory neurons. Front Cell Neurosci 8: 158
• Figueroa VA, Retamal MA, Cea LA, Salas JD, Vargas AA, Verdugo CA, Jara O, Martinez AD, Sáez JC. Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca²⁺ signaling in HeLa cells. Front Cell Neurosci 8: 265
• Retamal MA, Sáez JC. Hemichannels; from the molecule to the function. Front Physiol 5: 411.
• León-Paravic CG, Figueroa V, Guzmán DJ, Valderrama CF, Vallejos AA, Fiori MC, Altenberg GA, Reuss L, Retamal MA. Carbon Monoxide (CO) a novel inhibitor of connexin hemichannels. J Biol Chem 289: 36150-36157
• Retamal MA, Reyes EP, Alcayaga J. Petrosal ganglion: a more complex role than originally imagined. Front Physiol 5: 474
• Fernández R, Nardocci G, Navarro C, Reyes EP, Acuña-Castillo C, Cortés PP. Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy. Front Physiol 5: 489

2013

• Figueroa V, Sáez PJ, Salas JD, Salas D, Jara O, Martínez AD, Sáez JC, Retamal MA. Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca²⁺-dependent pathway. Biochem Biophys Acta 1828: 1169–1179
• Sáez PJ, Shoji KF, Retamal MA, Harcha PA, Ramírez G, Jiang JX, von Bernhardi R, Saez JC. ATP is required and advances cytokine-induced gap junction formation in microglia in vitro. Mediators Inflamm 2013: 216402. 16 pages. doi: 10.1155/2013/216402
• Iyyathurai J, D’hondt C, Wang N, De Bock M, Himpens B, Retamal MA, Stehberg J, Leybaert L, Bultynck G. Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: gap junctions versus hemichannels. Neuropharmacology 75: 491-505
• Orellana JA, Martinez AD, Retamal MA. Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules. Neuropharmacology 75: 567-582
• Giaume C, Froger N, Orellana JA, Retamal MA, Sáez JC. Impact of microglial activation on astroglial connexin expression and function in brain inflammation. Chapter 11 in: E Oviedo-Orta, BR Kwak, WH Evans, eds: «Connexin Cell Communication Channels. Roles in the Immune System and Immunopathology«, pp 219-232. CRC Press: Taylor and Francis group. ISBN: 978-1-4398-6257-5

2012

• Vielma AH, Retamal MA, Schmachtenberg O. Nitric oxide signaling in the retina: What have we learned in two decades? Brain Res 1430: 112-125
• Stehberg J, Moraga-Amaro R, Salazar C, Becerra A, Echeverría C, Orellana JA, Bultynck G, Ponsaerts R, Leybaert L, Simon F, Sáez JC, Retamal MA. Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J 26: 3649-3657
• Bravo I, Michea L. Análisis de la evidencia experimental que muestra efectos nocivos de la sal y su relación con la hipertensión arterial. Medwave 12 (2): e5303. available online. doi: 10.5867/medwave.2012.02.5303
• Zapata P, Larraín C, Reyes EP, Fernández R. Shifting from hypoxia to hyperoxia to assess the peripheral chemosensory drive of ventilation. Adv Exp Med Biol 758: 137-142
• Reyes EP, Abarzua M, Martin A, Rodríguez J, Cortés PP, Fernández R.  LPS-induced    c-Fos activation in NTS neurons and plasmatic cortisol increases in septic rats are suppressed by bilateral carotid chemodenervation. Adv Exp Med Biol 758: 185-190

2011

• Retamal MA, Evangelista-Martínez F, León-Paravic CG, Altenberg GA, Reuss L. Biphasic effect of linoleic acid on connexin 46 hemichannels. Pflügers Arch – Eur J Physiol 461: 635–643.
• Retamal MA, León-Paravic CG, Verdugo CA, Alcaíno CA, Moraga-Amaro R, Stehberg J. Connexin in lens physiology and cataract formation. J Clin Exp Ophthalmol, sp issue 1, 13 pp, available online. doi:10.4172/2155-9570.S1-001
• Brown ST, Reyes EP, Nurse CA. Chronic hypoxia upregulates adenosine 2a receptor expression in chromaffin cells via hypoxia inducible factor-2a: Role in modulating secretion. Biochem Biophys Res Comm 412: 466–472
• Zapata P, Larraín C, Reyes P, Fernández R. Immunosensory signaling by carotid body chemoreceptors. Respir Physiol Neurobiol 178: 370-374

2010

• Retamal MA, Yin S, Altenberg GA, Reuss L. Voltage-dependent facilitation of Cx46 hemichannels. Am J Physiol Cell Physiol 298: C132-139
• Ponsaerts R, De Vuyst E, Retamal M, D’hondt C, Vermeire D, Wang N, De Smedt H, Zimmermann P, Himpens B, Vereecke J, Leybaert L, Bultynck G. Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity. FASEB J 24: 4378-4395.
• Sáez JC, Schalper KA, Retamal MA, Orellana JA, Shoji KF, Bennett MV. Cell membrane permeabilization via connexin hemichannels in living and dying cells. Exp Cell Res 316: 2377-2389.

2009

• Fitzgerald RS, Eyzaguirre C, Zapata P. Fifty years of progress in carotid body physiology. Adv Exp Med Biol 648: 23-34
• Zapata P, Larraín C, Rivera MA, Calderón C. Cardio-vascular responses to hyperoxic withdrawal of arterial chemosensory drive. Adv Exp Med Biol 648: 305-314
• Retamal MA, Yin S, Altenberg GA, Reuss L. Modulation of Cx46 hemichannels by nitric oxide. Am J Physiol Cell Physiol 296: C1356-1363.

2008

• Fernández R, González S, Rey S, Cortés PP, Maisey KR, Reyes EP, Larraín C, Zapata P. Lipopolysaccharide-induced carotid body inflammation in cats: Functional manifestations, histopathology and involvement of tumour necrosis factor-a. Exp Physiol 93: 892-907

2007

• Reyes EP, Fernández R, Larraín C, Zapata P. Effects of combined cholinergic-purinergic block upon cat carotid body chemoreceptors in vitro. Respir Physiol Neurobiol 156: 17-22
• Reyes EP, Fernández R, Larraín C, Zapata P. Carotid body chemosensory activity and ventilatory chemoreflexes in cats persist after combined cholinergic–purinergic block. Respir Physiol Neurobiol 156: 23-32
• Zapata P. Is ATP a suitable co-transmitter in carotid body arterial chemoreceptors? Respir Physiol Neurobiol 157: 106-115
• Eyzaguirre C. Electric synapses in the carotid body-nerve complex. Respir Physiol Neurobiol 157: 116-122

2006

• Reyes EP, Alcayaga J, Zapata P. Are there interactions between acetylcholine- and ATP-induced responses at the level of a visceral sensory ganglion? Brain Res 1107: 97-103

2005

• Zapata P, Larraín C. How the carotid body works: Different strategies and preparations to solve different problems. Biol Res 38: 315-328

Papers

• “Carbon Monoxide (CO) is a novel inhibitor of connexin hemichannels”. Mauricio Retamal.
• Connexin and Pannexin hemichannels are regulated by redox potential. Mauricio Retamal.
• Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals. Edison Pablo Reyes, Verónica Cerpa, Liliana Corvalán y Mauricio Antonio Retamal.