Lorena Lobos, PhD

llobos@udd.cl

• Bioquímico, P. Universidad Católica de Valparaíso. Magíster en Bioquímica, Universidad de Chile. Doctor en Bioquímica, Universidad de Chile.

Cargo actual 

• Investigador docente, Centro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo.
• Director Tesis de Doctorado: Eduardo Durán, Alumno del Doctorado de Ciencias Médicas e Innovación en Medicina, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo / Título: Estudio in vitro e in vivo del rol pro-metastásico de CAV1 en exosomas originados a partir de la línea celular de cáncer de mama metastásico.

Línea de investigación

• Exosomas; capacidad de preparar nichos metastásicos en cáncer de mama.

Publicaciones (27 indexadas NCBI; 4 Capitulo de libro; 1 NCBI sequence; 2 No indexadas)

• Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant  breast cancer cells. L Lobos-González*, R Bustos, A Campos, V Silva, V Silva, E Jeldes, C Salomon, M Varas-Godoy, A Caceres-Verschae, E Duran, T Vera, F Ezquer, M Ezquer, J Villegas, VA. Burzio. Scientific Reports, 10 (343) 2020 *Correspondig Author
• Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors. V Borgna&, L Lobos-González&, F Guevara, E Landerer, M Bendek, R Ávila, V Silva, C Villota, M Araya, A Rivas*, C López, T Socias, J Castillo, L Alarcón, LO. Burzio, VA. Burzio and J Villegas J Cancer 11(7):1780-1791 2020 &equal contribution
• Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells. Ortiz R, Díaz J, Díaz-Valdivia N, Martínez S, Contreras P, Lobos-González L, Guerrero S, Leyton L, Quest AFG. Biochem Pharmacol  30;177:113941  2020
• The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis. Díaz-Valdivia NI, Díaz J, Contreras P, Campos A, Rojas-Celis V, Burgos-Ravanal RA, Lobos-González L, Torres VA, Perez VI, Frei B, Leyton L, Quest AFG. Oncogene. Mar 9. doi: 10.1038/s41388-020-1242-3.  2020
• Arce M, Pinto MP, Galleguillos M, Muñoz C, Lange S, Ramirez C, Erices R, Gonzalez P, Velasquez E, Tempio F, Lopez MN, Salazar-Onfray F, Cautivo K, Kalergis AM, Cruz S, Lladser Á, Lobos-González L, Valenzuela G, Olivares N, Sáez C, Koning T, Sánchez FA, Fuenzalida P, Godoy A, Contreras Orellana P, Leyton L, Lugano R, Dimberg A, Quest AFG, Owen GI. Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation. Cancers (Basel). 2019 Aug 2;11(8). doi: 10.3390/cancers11081103.
• Campos A, Burgos-Ravanal R, González MF, Huilcaman R, Lobos González L, Quest AFG. Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis. Biomolecules. 2019 Jul 29;9(8). doi: 10.3390/biom9080314.
• Fitzpatrick C, Bendek MF, Briones M, Farfán N, Silva VA, Nardocci G, Montecino M, Boland A, Deleuze JF, Villegas J, Villota C, Silva V, Lobos-Gonzalez L, Borgna V, Barrey E, Burzio LO, Burzio VA. Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors. Cell Death Dis. 2019 May 29;10(6):423. doi: 10.1038/s41419-019-1649-3.
• Arce, M., Pinto, M. P., Galleguillos, M., Muñoz, C., Lange, S., Ramirez, C., Erices, R., Gonzalez, P., Velasquez, E., Tempio, F., López, M. N., Salazar-Onfray, F., Cautivo, K., Kalergis, A. M., Cruz, S., Lladser, A., Lobos-Gonzalez, L., Valenzuela, G., Olivares, N., Sáez, C., Koning, T., Sánchez, F. A., Fuenzalida, P., Godoy, A., Contreras-Orellana, P., Leyton, L., Lugano, R., Dimberg, A., Quest, A. F. G., Owen, G. Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation, CANCERS, Ago 2019, DOI: 10.3390/cancers11081103
• Campos, America; Burgos-Ravanal, Renato; Fernanda Gonzalez, Maria; Huilcaman, Ricardo; Lobos Gonzalez, Lorena; Geoffery Quest, Andrew Frederick. Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis, BIOMOLECULES, Ago 2019, DOI: 10.3390/biom9080314
• Campos A, Salomon C, Bustos R, Díaz J, Martínez S, Silva V, Reyes C, Díaz-Valdivia N, Varas-Godoy M, Lobos González L*, Quest A.F.G**Correspondig Author Extracellular vesicles containing Caveolin-1 from metastatic breast cancer cells are enriched in adhesion proteins and enhance migration and invasion of recipient cells. Nanomedicine (Lond). 2018 Oct;13(20):2597-2609. doi: 10.2217/nnm-2018-0094. Epub 2018 Oct 19
• S Guerrero, V Diaz-Garcia, P Contreras-Orellana, P Lara, S Palma, F Guzman, L Lobos-González, A Cárdenas, X Rojas-Silva, L Muñoz, L Leyton, M J. Kogan, A F. G. Quest. Gold nanoparticles as tracking devices to shed light on the role of Caveolin-1 in early stages of melanoma metastasis. Nanomedicine (Lond). 2018 Jun;13(12):1447-1462. doi: 10.2217/nnm-2017-0390. Epub 2018 Jul 4.
• Díaz-García V.M, Guerrero S, Díaz N, Lobos-González L, Catalán J, Kogan M. J, Pérez-Donoso J. M and Quest A.F.G. Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging. International Journal of Nanomedicine, 16 October 2018 Volume 2018:13 Pages 6391—6412 doi: https://doi.org/10.2147/IJN.S165565

Capítulo de libro

• J Villegas Olavarria, VA. Burzio, V Borgna, L Lobos-Gonzalez, M Araya, F Guevara, C Villota and Luis O. Burzio. Long Noncoding Mitochondrial RNAs (LncmtRNAs) as Targets for Cancer Therapy. https://www.intechopen.com/books/mitochondrial-dna-new-insights/long-noncoding-mitochondrial-rnas-lncmtrnas-as-targets-for-cancer-therapy  (2018)