Paula Muñoz, MD

Directora

  • Directora Centro de Estudios Clínicos
  • Licenciatura en Medicina, Universidad de los Andes.
  • Médico Cirujano, Universidad de los Andes.
  • Postgrado en Neurología, Universidad de Valparaíso.
  • Pasantía Servicio de Neurología, Unidad de Tratamiento Neurovascular y Rehabilitación, Groupe Hospitalier Lariboisière – Fernand-Widal, Paris, Francia (2008).
  • Pasantía Unidad de Neurología Vascular Clínica Alemana de Santiago (2009).
  • Fellowship en Neurología Vascular, Clínica Alemana-Universidad del Desarrollo (2011-2010).
  • 2013 – 2016 PhD – Doctor in Philosophy (Medicine), University of Sydney, Sydney, Australia y PhD student, The George Institute for Global Health, Sydney, Australia. Tesis: Head Positioning and Other Strategies in Stroke Care (2013-2016).

Experiencia en investigación

  • Integrante de Comité Ético Científico de la Facultad de Medicina Clínica Alemana Universidad del Desarrollo desde 2017
  • Honorary Senior Fellow, The George Institute for Global Health, desde 2017.
  • Regional Project Manager del Centro de Coordinación Regional para Sudamérica del Estudio HeadPoST (Head Position in Stroke Trial) años 2014-2017. Patrocinador: The George Institute for International Health University of Sydney, Australia, Investigador principal: Craig Anderson PhD FRACP
  • Integrante del Steering Committee del Estudio HeadPoST PILOTO (Head Position in Stroke Trial) años 2013-2016. Patrocinadores: Clínica Alemana de Santiago y The George Institute for International Health University of Sydney, Australia, Investigador principal: Verónica Olavarría, MD
  • Coordinadora local del Estudio HeadPoST PILOTO (Head Position in Stroke Trial) en el Hospital Royal Prince Alfred, Sydney, Australia años 2013-2014. Patrocinadores: Clínica Alemana de Santiago y The George Institute for International Health University of Sydney, Australia, Investigador principal: Verónica Olavarría MD
  • Coordinadora regional y de Clínica Alemana de Santiago del Estudio INTERACT 2 “The second intensive blood pressure reduction in acute cerebral haemorrhage trial”, 2011-2012, Patrocinador: The George Institute for International Health University of Sydney, Australia, Investigador principal: Craig Anderson PhD FRACP
  • Investigadora y coordinadora del Estudio INTERACT 2 “The second intensive blood pressure reduction in acute cerebral haemorrhage trial”, 2010-2012, Patrocinador: The George Institute for International Health University of Sydney, Australia, Investigador principal: Craig Anderson PhD FRACP
  • Investigadora Estudio OPTIC CLOPI_R_01789, “Registro de evolución de pacientes con TIA y enfermedad cerebrovascular”, años 2007 a 2010. Patrocinador: Sanofi-Aventis, Directora del estudio: Dra. Pascale Blondin, Presidente Comité Directivo: Dr. Pierre Amarenco
  • Tesis de título Neurología adultos Universidad de Valparaíso: “Prevención secundaria en pacientes con accidente cerebrovascular isquémico. Estudio prospectivo. Hospital Carlos Van Buren”, tutor Dr. Claudio Sacks.

Publicaciones

  • CS Anderson, H. Arima, P. Lavados, L. Billot, M.L. Hackett, V.V. Olavarría, P. Muñoz Venturelli, A. Brunser, B. Peng, L. Cui, L. Song, K. Rogers, S. Middleton, J.Y. Lim, D. Forshaw, C.E. Lightbody, M. Woodward, O. Pontes‑Neto, H.A. De Silva, R.-T. Lin, T.-H. Lee, J.D. Pandian, G.E. Mead, T. Robinson, and C. Watkins, for the HeadPoST Investigators and Coordinators. Cluster randomized, Cross-over trial of Head Positioning in Acute Stroke N Engl J Med. 2017 Jun 22;376(25):2437-2447.
  • Verónica V Olavarría, Pablo M Lavados, Paula Muñoz-Venturelli, Francisca González, Javier Gaete, Sheila Martins, Hisatomi Arima, , Craig S Anderson, Alejandro M Brunser. Flat-head positioning increases cerebral blood flow in anterior circulation acute ischemic stroke. A cluster randomized phase IIb trial. Int J Stroke. 2017 Jan 1:1747493017711943.
  • Laurent Billot, Mark Woodward, Hisatomi Arima, Maree L Hackett, Paula Muñoz Venturelli, Pablo M Lavados, Alejandro Brunser, Bin Peng, Liying Cui, Lily Song, Stephane Heritier, Stephen Jan, Sandy Middleton, Verónica V Olavarría, Joyce Lim, Thompson Robinson, Octavio Pontes-Neto, Caroline Watkins, Craig S Anderson. Statistical analysis plan for the Head Position in Stroke Trial (HeadPoST): An international cluster cross-over randomized trial Int J Stroke. 2017 Aug;12(6):667-670.
  • Paula Muñoz-Venturelli, Thompson Robinson, Pablo M. Lavados, Verónica V. Olavarría, Hisatomi Arima, Laurent Billot, Maree L. Hackett, Joyce Y. Lim, Sandy Middleton, Octavio Pontes-Neto, Bin Peng, Liying Cui, Lily Song, Gillian Mead, Caroline Watkins, Ruey-Tay Lin, Tsong-Hai Lee, Jeyaraj Pandian, H. Asita de Silva, Craig S. Anderson. Regional variation in acute stroke care organisation. J Neurol Sci. 2016 Dec 15;371:126-130
  • Brunser AM, Lavados PM, Hoppe A, Muñoz-Venturelli P, Sujima E, López J,Mansilla E, Cárcamo D, Díaz V. Transcranial Doppler as a Predictor of Ischemic Events in Carotid Artery Dissection. J Neuroimaging. 2017 Mar;27(2):232-236. doi:10.1111/jon.12379. Epub 2016 Aug 5. PubMed PMID: 27491878
  • Paula Muñoz-Venturelli, Alejandro M. Brunser, Javier Gaete, Sergio Illanes, Javiera López, Verónica V. Olavarría, Andrés Reccius, Pablo Brinck, Francisca González, Gabriel Cavada, Pablo M. Lavados. Reliability of Transcranial Doppler with M-mode Ultrasound in Middle Cerebral Artery Measurement. Journal of medical ultrasound, online JAN-4-2017, https://doi.org/10.1016/j.jmu.2016.12.001
  • Paula Muñoz Venturelli, Xia Wang, Darin B. Zahuranec, Pablo M Lavados, Christian Stapf, Richard Lindley, Candice Delcourt, John Chalmers, Craig S. Anderson, Thompson G. Robinson, for the INTERACT2 Investigators. Withdrawal of active treatment after intracerebral haemorrhage in the INTERACT2 study. Age and Ageing 2017 Mar 1;46(2):329-332. doi: 10.1093/ageing/afw187. PubMed PMID:27831492
  • Katja E. Wartenberg, Xia Wang, Paula Muñoz-Venturelli, Alejandro A. Rabinstein, Pablo M Lavados, Craig S Anderson, Thompson Robinson. Intensive Care Unit Admission for Patients in the INTERACT2 ICH Blood Pressure Treatment Trial: characteristics, predictors, and outcomes. Neurocrit Care 26 (3), 371-378. 6 2017.
  • Olavarría VV, Arima H, Anderson CS, Brunser A, Muñoz-Venturelli P, Billot L, Lavados PM; HEADPOST Pilot Investigators. Statistical analysis plan of the head position in acute ischemic stroke trial pilot (HEADPOST pilot). Int J Stroke. 2016 Oct 14. pii: 1747493016674955.
  • Muñoz-Venturelli P, Wang X, Lavados PM, Stapf C, Robinson T, Lindley R, Heeley E, Delcourt C, Chalmers J, Anderson CS; INTERACT2 Investigators. Prophylactic heparin in acute intracerebral hemorrhage: a propensity score-matched analysis of the INTERACT2 study. Int J Stroke. 2016 Jul;11(5):549-56.
  • Saxena A, Anderson CS, Wang X, Sato S, Arima H, Chan E, Muñoz-Venturelli P, Delcourt C, Robinson T, Stapf C, Lavados PM, Wang J, Neal B, Chalmers J, Heeley E; INTERACT2 Investigators. Prognostic Significance of Hyperglycemia in Acute Intracerebral Hemorrhage: The INTERACT2 Study. Stroke. 2016 Mar;47(3):682-8.
  • Brunser AM, Hoppe A, Muñoz P, Lavados PM, Illanes S, Díaz V, Olavarría VV. Thrombolysis in stroke mimics: Experience in 10 cases. Rev Med Chil. 2016 Oct;144(10):1266-1269. doi: 10.4067/S0034-98872016001000005. PubMed PMID: 28074981.
  • Brunser AM, Muñoz Venturelli P, Lavados PM, Gaete J, Martins S, Arima H, Anderson CS, Olavarría VV. Head position and cerebral blood flow in acute ischemic stroke patients: Protocol for the pilot phase, cluster randomized, Head Position in Acute Ischemic Stroke Trial (HeadPoST pilot). Int J Stroke. 2016 Feb;11(2):253-9.
  • Paula Muñoz-Venturelli, Hisatomi Arima, Pablo Lavados, Alejandro Brunser, Bin Peng, Liying Cui, Lily Song, Laurent Billot, Elizabeth Boaden, Maree L. Hackett, Stephane Heritier, Stephen Jan, Sandy Middleton, Verónica V. Olavarría, Joyce Y. Lim, Richard I. Lindley, Emma Heeley, Thompson Robinson, Octavio Pontes-Neto, Lkhamtsoo Natsagdorj, Ruey-Tay Lin, Caroline Watkins, Craig S. Anderson, and for the HeadPoST Collaborative Investigators. Head Position in Stroke Trial (HeadPoST) – sitting-up vs lying-flat positioning of patients with acute stroke: study protocol for a cluster randomised controlled trial. Trials. 2015; 16: 256
  • Xia Wang, Hisatomi Arima, Jie Yang, Shihong Zhang, Guojun Wu, Mark Woodward, Paula Muñoz-Venturelli, Pablo M Lavados, Christian Stapf, Thompson Robinson, Emma Heeley, Candice Delcourt, Richard I Lindley, Mark Parsons, John Chalmers, Craig S. Anderson; for the INTERACT2 Investigators. Mannitol and outcome in intracerebral hemorrhage: propensity score matched and multivariable INTERACT2 results. Stroke. 2015 Oct;46(10):2762-7.
  • Muñoz Venturelli P, Olavarría V, González F, Brunser A, Lavados P, Arima H, Anderson CS. Head Position in the Early Phase of Acute Ischemic Stroke: An International Survey of Current Practice. J Stroke Cerebrovasc Dis. 2015 Jul;24(7):1564-9
  • Alejandro M. Brunser, Pablo M. Lavados, Daniel A. Cárcamo, Arnold Hoppe, Verónica V. Olavarría, Javiera López, Paula Muñoz, Rodrigo Rivas. Accuracy of Power Mode Transcranial Doppler in the Diagnosis of Brain Death. Journal of medical ultrasound. 2015 March Volume 23, Issue 1, Pages 29–33
  • Olavarría VV, Arima H, Anderson CS, Brunser AM, Muñoz-Venturelli P, Heritier S, Lavados PM. Head position and cerebral blood flow velocity in acute ischemic stroke: a systematic review and meta-analysis. Cerebrovasc Dis. 2014 Jun 28;37(6):401-408.
  • Brunser A, Hoppe A, Muñoz P, Cárcamo D, Lavados PM, Gaete J, Roldán A, Rivas R. Sonothrombolysis for acute ischemic stroke. Rev Med Chil. 2014 Oct;142(10):1238-44
  • Muñoz-Venturelli P, Sacks C, Madrid E, Lavados PM. Long-term Adherence to National Guidelines for Secondary Prevention of Ischemic Stroke: A Prospective Cohort Study in a Public Hospital in Chile. J Stroke Cerebrovasc Dis. 2014 Mar;23(3):490-5
  • Brunser AM, Illanes S, Lavados PM, Muñoz P, Cárcamo D, Hoppe A, Olavarria VV, Delgado I, Díaz V. Exclusion Criteria for Intravenous Thrombolysis in Stroke Mimics: An Observational Study. J Stroke Cerebrovasc Dis. 2013 Oct;22(7):1140-5
  • Brunser AM, Hoppe A, Illanes S, Díaz V, Muñoz P, Cárcamo D, Olavarria V, Valenzuela M, Lavados P. Accuracy of Diffusion-Weighted Imaging in the Diagnosis of Stroke in Patients With Suspected Cerebral Infarct. Stroke. 2013;44:1169-71
  • Brunser A, Silva C, Cárcamo D, Muñoz P, Hoppe A, Olavarria VV, Díaz V, Abarca J. Transcranial Doppler in a Hispanic-Mestizo population with neurological diseases: a study of sonographic windows and its determinants. Brain Behav 2012;23:231-6
  • Araya P, Sacks C, Muñoz P, Gigoux JP, García L et al. Vasculitis Primaria de Sistema Nervioso Central, diagnóstico diferencial de demencia subaguda. Rev Méd Chile 2009;137:807-810. Capítulo 62: Dieta y esclerosis múltiple. Claudio Sacks, Pilar Peredo-Orellana, Paula Muñoz-Venturelli. En: Esclerosis múltiple Una mirada ibero – panamericana. Editores Arriagada C, Nogales-Gaete J, Editorial Demos 2008. p. 365-9.